CD30 Is a CD40-Inducible Molecule that Negatively Regulates CD40-Mediated Immunoglobulin Class Switching in Non-Antigen-Selected Human B Cells

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells

1985 • 1,817 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

CD40-CD40 ligand

2000 • 1,376 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

Identification and Characterization of an IκB Kinase

1997 • 1,166 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

Augmented humoral and anaphylactic responses in FcγRII-deficient mice

1996 • 828 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

How B and T cells talk to each other

1994 • 659 citations

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease

1992 • 654 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

1993 • 541 citations

Identification of Hodgkin and sternberg‐reed cells as a unique cell type derived from a newly‐detected small‐cell population

1982 • 421 citations

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

1996 • 414 citations

Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells

1995 • 398 citations

B cell differentiation and isotype switching is related to division cycle number.

1996 • 393 citations

Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells

1997 • 385 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

Antibody Class Switching

1996 • 327 citations

CD40-CD40 Ligand: A Multifunctional Receptor-Ligand Pair

1996 • 326 citations

BER-H2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol- resistant epitope

1989 • 315 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival

1997 • 224 citations

CD40 Ligand and Appropriate Cytokines Induce Switching to IgG, IgA, and IgE and Coordinated Germinal Center and Plasmacytoid Phenotypic Differentiation in a Human Monoclonal IgM+IgD+ B Cell Line

1998 • 212 citations

I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction.

1996 • 210 citations

Jak3 Is Associated with CD40 and Is Critical for CD40 Induction of Gene Expression in B Cells

1997 • 207 citations

TRAF-interacting Protein (TRIP): A Novel Component of the Tumor Necrosis Factor Receptor (TNFR)- and CD30-TRAF Signaling Complexes That Inhibits TRAF2-mediated NF-κB Activation

1997 • 196 citations

CD40-mediated signaling in B cells. Balancing cell survival, growth, and death.

1996 • 186 citations

CD30-mediated signaling promotes the development of human T helper type 2-like T cells.

1995 • 179 citations

CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination.

1998 • 161 citations

Induction of Cell Cycle Arrest and B Cell Terminal Differentiation by CDK Inhibitor p18 and IL-6

1997 • 159 citations

CD154/CD40 and CD70/CD27 interactions have different and sequential functions in T cell-dependent B cell responses: enhancement of plasma cell differentiation by CD27 signaling.

1997 • 136 citations

Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells. Anti-Ig down-regulates Fas expression of CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis.

1996 • 108 citations

Assembly and Regulation of the CD40 Receptor Complex in Human B Cells

1997 • 101 citations

Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells.

1994 • 86 citations

Polymerase Chain Reaction Selects a Novel Disintegrin Proteinase from CD40-Activated Germinal Center Dendritic Cells

1997 • 86 citations

Identification of a source of biologically active CD40 ligand

1992 • 81 citations

Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interactin vivowith the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation

1996 • 78 citations

Co-receptors of B lymphocytes

1997 • 73 citations

Recombinant CD30 ligand and CD40 ligand share common biological activities on Hodgkin and Reed‐Sternberg cells

1995 • 71 citations

Regulation of human B cell function by recombinant CD40 ligand and other TNF-related ligands.

1995 • 61 citations

A CD30 responsive element in the germline ϵ promoter that is distinct from and inhibitory to the CD40 response element

1996 • 7 citations