Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by Rapid Up-Regulation of B7-1 and B7-2

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

The clonal selection theory of acquired immunity

1959 • 2,008 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

The B7 and CD28 receptor families

1994 • 1,342 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B70 antigen is a second ligand for CTLA-4 and CD28

1993 • 907 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 860 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

How B and T cells talk to each other

1994 • 659 citations

The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.

1994 • 607 citations

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

1993 • 569 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Identification of an Alternative CTLA-4 Ligand Costimulatory for T Cell Activation

1993 • 517 citations

Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.

1992 • 510 citations

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

1993 • 494 citations

Antigen‐Driven Selection of Virgin and Memory B Cells

1986 • 476 citations

Germinal center cells express bcl‐2 protein after activation by signals which prevent their entry into apoptosis

1991 • 446 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

The clonal selection theory of acquired immunity

1960 • 396 citations

B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.

1994 • 347 citations

Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3.

1994 • 330 citations

CD28-B7 interactions in T-cell activation

1994 • 315 citations

Antigen-driven B cell differentiation in vivo.

1993 • 308 citations

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

1994 • 293 citations

T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes.

1987 • 286 citations

T and B memory cells

1994 • 285 citations

Memory B cells in T cell-dependent antibody responses colonize the splenic marginal zones

1988 • 272 citations

Progress in immunology V

1985 • 268 citations

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

1988 • 260 citations

Immunological Memory

1993 • 250 citations

Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.

1992 • 214 citations

CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production.

1994 • 210 citations

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

1993 • 207 citations

The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response.

1990 • 200 citations

THE CARRIAGE OF IMMUNOLOGICAL MEMORY BY SMALL LYMPHOCYTES IN THE RAT

1966 • 195 citations

Do B cells drive the diversification of immune responses?

1993 • 189 citations

Memory B and T Cells

1991 • 183 citations

Immunological Memory

1993 • 166 citations

T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity.

1994 • 149 citations

Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes.

1993 • 145 citations

A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation.

1994 • 133 citations

Microbial induction of co-stimulatory activity for CD4 T-cell growth

1991 • 130 citations

Requirements for CD28-dependent T cell-mediated cytotoxicity.

1993 • 125 citations

Expansion, Selection and Maintenance of Memory B-Cell Clones

1990 • 66 citations

Phenotypic and functional heterogeneity of the IgD⁻ B cell compartment: identification of two major tonsillar B cell subsets

1993 • 65 citations

Marginal zone B cells respond both to polysaccharide antigens and protein antigens

1991 • 60 citations

Human T-Cell Memory

1990 • 44 citations

Five Human Mature B Cell Subsets

1994 • 34 citations

Switch recombination in normal IgA1+ Blymphocytes.

1994 • 26 citations

Evolutionary and Somatic Immunological Memory

1989 • 24 citations

Induction of competence to respond to IL-4 by CD4+ T helper type 1 cells requires costimulation.

1992 • 18 citations

In Vivo Immunology

1994 • 12 citations

Memory B And T Cells

1991 • 6 citations