Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

Ribonucleic acid isolated by cesium chloride centrifugation

1974 • 2,263 citations

Dideoxy sequencing method using denatured plasmid templates

1986 • 1,537 citations

Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.

1984 • 652 citations

Polyadenylic Acid Sequences in the Heterogeneous Nuclear RNA and Rapidly-Labeled Polyribosomal RNA of HeLa Cells: Possible Evidence for a Precursor Relationship

1971 • 503 citations

Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin.

1980 • 429 citations

Evolution of human immunoglobulin kappa J region genes.

1982 • 318 citations

Clustering of extensive somatic mutations in the variable region of an immunoglobulin heavy chain gene from a human B cell lymphoma

1986 • 279 citations

Human B cell development. II. Subpopulations in the human fetus.

1985 • 257 citations

Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing

1978 • 211 citations

An antigen shared by a human T cell subset and B cell chronic lymphocytic leukemic cells. Distribution on normal and malignant lymphoid cells.

1980 • 186 citations

A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.

1986 • 166 citations

A new human T-cell differentiation antigen: Unexpected expression on chronic lymphocytic leukemia cells

1980 • 166 citations

Evolution of immunoglobulin V genes: Evidence indicating that recently duplicated human Vκ sequences have diverged by gene conversion

1983 • 165 citations

Human immunoglobulin variable region genes—DNA sequences of two Vκ genes and a pseudogene

1980 • 139 citations

Somatic Mutation in Human B‐Cell Tumors

1987 • 122 citations

Anti-Human Immunoglobulin G Activity of Membrane-Bound Monoclonal Immunoglobulin M in Lymphoproliferative Disorders

1972 • 121 citations

Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments.

1987 • 118 citations

A common idiotope on human rheumatoid factors identified by a hybridoma antibody

1983 • 114 citations

Human Vκ immunoglobulin gene number: Implications for the origin of antibody diversity

1981 • 111 citations

Immunoglobulin genes of different subgroups are interdigitated within the V_Klocus

1984 • 110 citations

Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene

1985 • 109 citations

HTLV-I—Associated B-Cell CLL: Indirect Role for Retrovirus in Leukemogenesis

1987 • 108 citations

Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type

1984 • 107 citations

High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia.

1987 • 99 citations

Genetic influence on the levels of circulating CD5 B lymphocytes.

1987 • 99 citations

Fetal and neonatal development of human spleen: an immunohistological study.

1987 • 88 citations

Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype.

1981 • 86 citations

Spontaneous Alteration of Idiotype in a Monoclonal B-Cell Lymphoma

1985 • 81 citations

Genetic Factors Predisposing to Chronic Lymphocytic Leukemia and to Autoimmune Disease1

1980 • 81 citations

A large section of the gene locus encoding human immunoglobulin variable regions of the Kappa type is duplicated

1985 • 80 citations

Studies on B lymphoid tumors treated with monoclonal anti-idiotype antibodies: correlation with clinical responses

1987 • 79 citations

Preferential association of kappa IIIb light chains with monoclonal human IgM kappa autoantibodies.

1983 • 78 citations

Sequence similarities and cross-idiotypic specificity of L chains among human monoclonal IgM kappa with anti-gamma-globulin activity.

1985 • 76 citations

Most κ immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes

1984 • 75 citations

Light Chain Sequences of Human IgM Cold Agglutinins

1972 • 73 citations

Composite human V_Kgenes and a model of their evolution

1984 • 71 citations

Human Immunoglobulin kappa light chain genes of subgroups II and III

1985 • 69 citations

Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity.

1987 • 62 citations

The human Vκ locus

1987 • 59 citations

Cross idiotypic specificity among cold agglutinins in relation to combining activity for blood group-related antigens.

1974 • 52 citations

Idiotype variant cell populations in patients with B cell lymphoma.

1986 • 52 citations

An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants.

1984 • 47 citations

Chronic Lymphocytic Leukemia

2012 • 34 citations

Amino acid sequence of the variable regions of light chains from two idiotypically cross-reactive human IgM anti-.gamma.-globulins of the Wa group

1981 • 29 citations

Structural similarities in the kappa light chains of human rheumatoid factor paraproteins and serum immunoglobulins bearing a cross-reactive idiotype.

1985 • 22 citations

Amino acid sequence of a light chain variable region of a human rheumatoid factor of the Wa idiotypic group, in part predicted by its reactivity with antipeptide antibodies

1986 • 20 citations

Human rheumatoid factor crossidiotypes. II. Primary structure-dependent crossreactive idiotype, PSL2-CRI, present on Wa monoclonal rheumatoid factors is present on Bla and other IgM kappa monoclonal autoantibodies.

1987 • 17 citations

The VKIIIb light chain sub-subgroup: restricted association with mu heavy chain in normal human serum.

1985 • 13 citations

Studies on B lymphoid tumors treated with monoclonal anti-idiotype antibodies: correlation with clinical responses

1987 • 5 citations