Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

1997 • 1,091 citations

The role of clonal selection and somatic mutation in autoimmunity

1987 • 714 citations

Analysis of somatic mutation in five B cell subsets of human tonsil.

1994 • 667 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement

1994 • 415 citations

The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

1994 • 390 citations

Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells.

1997 • 373 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn

1997 • 300 citations

Developmentally restricted immunoglobulin heavy chain variable region gene expressed at high frequency in chronic lymphocytic leukemia.

1989 • 239 citations

Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features.

1997 • 230 citations

Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens

1991 • 216 citations

Nucleotide sequence analysis of the V regions of two IgM cold agglutinins. Evidence that the VH4-21 gene segment is responsible for the major cross-reactive idiotype.

1991 • 204 citations

Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.

1988 • 177 citations

Evolutionary nucleotide replacements in DNA

1979 • 169 citations

Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias

1990 • 158 citations

Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells.

1995 • 137 citations

V_H4—21, A Human V_H Gene Segment Overrepresented in the Autoimmune Repertoire

1992 • 135 citations

Mutational analysis of an autoantibody: differential binding and pathogenicity.

1994 • 130 citations

Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma

1995 • 129 citations

The structural basis of germline-encoded VH3 immunoglobulin binding to staphylococcal protein A.

1993 • 125 citations

Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype.

1991 • 115 citations

Single amino acid substitution altering antigen-binding specificity.

1982 • 112 citations

Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia.

1987 • 109 citations

Lack of Allelic Exclusion in B Cell Chronic Lymphocytic Leukemia

1997 • 108 citations

The human heavy chain Ig V region gene repertoire is biased at all stages of B cell ontogeny, including early pre-B cells.

1997 • 105 citations

Lack of detectable somatic hypermutation in the V region of the Ig H chain gene of a human chronic B lymphocytic leukemia.

1988 • 91 citations

The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma.

1991 • 91 citations

Representation of rearranged VH gene segments in the human adult antibody repertoire.

1995 • 87 citations

High-frequency representation of a single VH gene in the expressed human B cell repertoire.

1993 • 83 citations

VH gene usage is multiple myeloma: complete absence of the VH4.21 (VH4- 34) gene

1996 • 79 citations

Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number.

1996 • 78 citations

Common clonal origin of chronic lymphocytic leukemia and high-grade lymphoma of Richter's syndrome

1993 • 72 citations

Junctional diversity is essential to antibody activity.

1984 • 63 citations

B cells of chronic lymphatic leukemia express V genes in unmutated form

1991 • 61 citations

Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia.

1992 • 60 citations

Human Ig heavy chain CDR3 regions in adult bone marrow pre-B cells display an adult phenotype of diversity: evidence for structural selection of DH amino acid sequences

1997 • 59 citations

Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation.

1989 • 59 citations

Examples of in vivo isotype class switching in IgM+ chronic lymphocytic leukemia B cells.

1996 • 59 citations

Cloning and sequence analysis of the VH and VL regions of an anti-myelin/DNA antibody from a patient with peripheral neuropathy and chronic lymphocytic leukemia.

1990 • 58 citations

B-chronic lymphocytic leukemias can undergo isotype switching in vivo and can be induced to differentiate and switch in vitro [see comments]

1996 • 53 citations

IgM-producing chronic lymphocytic leukemia cells undergo immunoglobulin isotype-switching without acquiring somatic mutations.

1996 • 52 citations

Polymorphism and Utilization of Human V_H Genes^a

1995 • 51 citations

Differential usage of an Ig heavy chain variable region gene by human B- cell tumors

1993 • 49 citations

An endogenous sialoprotein and a bacterial B cell superantigen compete in their VH family-specific binding interactions with human Igs.

1996 • 46 citations

Evidence for progenitors of chronic lymphocytic leukemia B cells that undergo intraclonal differentiation and diversification

1996 • 42 citations

Immunoglobulin genes in chronic lymphocytic leukemia.

1993 • 39 citations

Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia

1992 • 38 citations

The primary structure of the Fab fragment of protein KAU, a monoclonal immunoglobulin M cold agglutinin.

1991 • 38 citations

Developmental Origins, Specificities and Immunoglobulin Gene Biases of Murine Ly-1 B Cells

1992 • 37 citations

A single engineered amino acid substitution changes antibody fine specificity.

1994 • 29 citations

Analysis of Immunoglobulin V_H Gene Repertoire by an Anchored PCR‐Elisa^a

1995 • 29 citations

Differential Usage of an Autoantibody-associated V_HGene, V_H4-21, by Human B-cell Tumors

1995 • 25 citations

Molecular Analysis of Rearranged VH Genes during B Cell Chronic Lymphocytic Leukemia: Intraclonal Stability is Frequent but not Constant

1994 • 25 citations

Molecular analysis of VH and VL regions expressed in IgG-bearing chronic lymphocytic leukemia (CLL): further evidence that CLL is a heterogeneous group of tumors

1993 • 24 citations

Molecular Characterization of IgA- and/or IgG-Switched Chronic Lymphocytic Leukemia B Cells

1997 • 24 citations

Variable region gene analysis of pathologic human autoantibodies to the related i and I red blood cell antigens

1991 • 21 citations

Biased Usage of Variable and Constant‐Region Ig Genes by IgG⁺, CD5⁺ Human Leukemic B Cells^a

1992 • 21 citations

Vχ gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the Vχ locus and do not show somatic mutation

1993 • 16 citations

Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma

1995 • 13 citations

Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia

1992 • 6 citations

Common clonal origin of chronic lymphocytic leukemia and high-grade lymphoma of Richter's syndrome

1993 • 4 citations

Molecular Characterization of IgA- and/or IgG-Switched Chronic Lymphocytic Leukemia B Cells

1997 • 3 citations

Surface Phenotype and Immunoglobulin Heavy Chain Gene Usage in Chronic B‐Cell Leukemias

1995 • 1 citations