Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers

Sequences of proteins of immunological interest

1984 • 3,427 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Intraclonal generation of antibody mutants in germinal centres

1991 • 1,083 citations

Maturation of the immune response in germinal centers

1991 • 904 citations

Sites of specific B cell activation in primary and secondary responses to T cell‐dependent and T cell‐independent antigens

1991 • 743 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

1992 • 456 citations

CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans

2001 • 405 citations

Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers

1996 • 386 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.

1993 • 367 citations

Affinity maturation without germinal centres in lymphotoxin-α-deficient mice

1996 • 322 citations

Intrinsic Constraint on Plasmablast Growth and Extrinsic Limits of Plasma Cell Survival

2000 • 311 citations

Germinal Centers without T Cells

2000 • 292 citations

Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

1993 • 283 citations

Compromised Ox40 Function in Cd28-Deficient Mice Is Linked with Failure to Develop Cxc Chemokine Receptor 5–Positive Cd4 Cells and Germinal Centers

1999 • 275 citations

A Quasi-Monoclonal Mouse

1996 • 204 citations

Immunoglobulin switch transcript production in vivo related to the site and time of antigen-specific B cell activation.

1996 • 199 citations

Germinal Center Initiation, Variable Gene Region Hypermutation, and Mutant B Cell Selection without Detectable Immune Complexes on Follicular Dendritic Cells

2000 • 174 citations

T-independent type 2 antigens induce B cell proliferation in multiple splenic sites, but exponential growth is confined to extrafollicular foci

1999 • 122 citations

The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes

1985 • 120 citations

Sequential antigen‐specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c

1996 • 116 citations

Humoral Immune Responses inCr2−/− Mice: Enhanced Affinity Maturation but Impaired Antibody Persistence

2000 • 100 citations

Cutting Edge: Germinal Centers Can Be Induced in the Absence of T Cells

2001 • 84 citations

Comparative evaluation of the immune status of congenitally athymic and euthymic rat strains bred and maintained at different institutes: 1. Euthymic rats.

1992 • 14 citations