BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia.

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

1999 • 2,557 citations

Clonal selection and learning in the antibody system

1996 • 1,710 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

1998 • 899 citations

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

1997 • 815 citations

Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.

1993 • 691 citations

Alterations of a Zinc Finger-Encoding Gene, BCL-6 , in Diffuse Large-Cell Lymphoma

1993 • 680 citations

BCL-6 protein is expressed in germinal-center B cells

1995 • 582 citations

BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci

1998 • 539 citations

Mutation ofBCL-6Gene in Normal B Cells by the Process of Somatic Hypermutation of Ig Genes

1998 • 536 citations

LAZ3, a novel zinc–finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas

1993 • 444 citations

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.

1996 • 434 citations

B-Cell Chronic Lymphocytic Leukemia: A Bird of a Different Feather

1999 • 408 citations

The pathogenesis of chronic lymphocytic leukemia: analysis of the antibody repertoire

1994 • 390 citations

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma.

1995 • 359 citations

Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation

1997 • 348 citations

Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

1998 • 287 citations

Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.

1995 • 285 citations

BCL-6 gene product, a 92- to 98-kD nuclear phosphoprotein, is highly expressed in germinal center B cells and their neoplastic counterparts

1995 • 284 citations

Differential Rates of Somatic Hypermutation in VH Genes Among Subsets of Chronic Lymphocytic Leukemia Defined by Chromosomal Abnormalities

1997 • 237 citations

Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia

2000 • 204 citations

Chronic lymphocytic leukemia

1999 • 204 citations

Transcriptional repression by the proto-oncogene BCL-6.

1996 • 196 citations

Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire

1992 • 190 citations

The LAZ3/BCL6 oncogene encodes a sequence-specific transcriptional inhibitor: a novel function for the BTB/POZ domain as an autonomous repressing domain.

1995 • 148 citations

Nonimmunoglobulin Gene Hypermutation in Germinal Center B Cells

1999 • 123 citations

Lack of Allelic Exclusion in B Cell Chronic Lymphocytic Leukemia

1997 • 108 citations

Identification of three subgroups of B cell chronic lymphocytic leukemia based upon mutations of BCL-6 and IgV genes

2000 • 60 citations

Molecular single-cell analysis reveals that CD5-positive peripheral blood B cells in healthy humans are characterized by rearranged Vkappa genes lacking somatic mutation.

1997 • 57 citations

Somatic mutation of bcl-6 genes can occur in the absence of VH mutations in chronic lymphocytic leukemia

2000 • 50 citations