From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

Memantine in Moderate-to-Severe Alzheimer's Disease

2003 • 1,889 citations

Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

1985 • 1,294 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.

1994 • 863 citations

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

1994 • 791 citations

Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study

1995 • 786 citations

Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5

1989 • 766 citations

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

1993 • 764 citations

Nonenzymatic Browning in Vivo: Possible Process for Aging of Long-Lived Proteins

1981 • 754 citations

Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

1993 • 736 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: A combined fluorescent tracer and acetylcholinesterase analysis

1982 • 697 citations

Free radical generation by early glycation products: A mechanism for accelerated atherogenesis in diabetes

1990 • 696 citations

Glutamate activates multiple single channel conductances in hippocampal neurons

1987 • 691 citations

The significance of the cholinergic system in the brain during aging and in Alzheimer’s disease

2006 • 501 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Presynaptic Cholinergic Dysfunction in Patients with Dementia

1983 • 422 citations

The Neuropharmacological Basis for the Use of Memantine in the Treatment of Alzheimer's Disease

2003 • 408 citations

Excitatory amino acid receptors in the brain: membrane binding and receptor autoradiographic approaches

1990 • 397 citations

The role of NMDA receptors in learning and memory

1987 • 360 citations

ARTERIAL AND CEREBRAL VENOUS BLOOD

1942 • 356 citations

Analysis of microtubule-associated protein tau glycation in paired helical filaments.

1994 • 326 citations

IMPAIRED SYNTHESIS OF ACETYLCHOLINE IN BRAIN ACCOMPANYING MILD HYPOXIA AND HYPOGLYCEMIA

1976 • 312 citations

High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senescent macromolecules.

1985 • 312 citations

Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study

1991 • 303 citations

Sustained Dendritic Gradients of Ca ²⁺ Induced by Excitatory Amino Acids in CA1 Hippocampal Neurons

1988 • 301 citations

Rage: A Novel Cellular Receptor for Advanced Glycation End Products

1996 • 296 citations

The Role of Glutamate in Neurotransmission and in Neurologic Disease

1986 • 294 citations

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

1998 • 292 citations

Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders

1991 • 286 citations

Alterations in Expression of Glutamatergic Transporters and Receptors in Sporadic Alzheimer's Disease

2007 • 278 citations

Advanced glycation endproducts in ageing and Alzheimer's disease

1997 • 267 citations

Neuroprotective and symptomatological action of memantine relevant for alzheimer’s disease — a unified glutamatergic hypothesis on the mechanism of action

2000 • 258 citations

Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex

1989 • 251 citations

Cortical Pyramidal Neurone Loss May Cause Glutamatergic Hypoactivity and Cognitive Impairment in Alzheimer's Disease: Investigative and Therapeutic Perspectives

1993 • 233 citations

Learning impairment in rats by N-methyl-D-aspartate receptor antagonists

1988 • 222 citations

Advanced Glycation End Product (AGE)–Mediated Induction of Tissue Factor in Cultured Endothelial Cells Is Dependent on RAGE

1997 • 221 citations

Aging Decreases Oxidative Metabolism and the Release and Synthesis of Acetylcholine

1981 • 215 citations

Evidence of Glutamatergic Denervation and Possible Abnormal Metabolism in Alzheimer's Disease

1988 • 200 citations

The mnemon and its juices: neuromodulation of memory processes

1983 • 178 citations

Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of β-amyloid peptide

1997 • 171 citations

Age-related alterations in neurotransmitter receptors: An electrophysiological and biochemical analysis

1981 • 167 citations

Excitatory amino acid transmitters and their receptors in neural circuits of the cerebral neocortex

1990 • 166 citations

Oxidative energy metabolism in Alzheimer brain

1992 • 156 citations

Effects of the Uncompetitive NMDA Receptor Antagonist Memantine on Hippocampal Long‐term Potentiation, Short‐term Exploratory Modulation and Spatial Memory in Awake, Freely Moving Rats

1996 • 145 citations

Der Kohlenhydratstoffwechsel des menschlichen Gehirns

1963 • 134 citations

High correlation between the localization of [3H]TCP binding and NMDA receptors

1986 • 128 citations

AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?

2001 • 117 citations

Infusion of (+)-MK-801 and memantine — contrasting effects on radial maze learning in rats with entorhinal cortex lesion

1996 • 112 citations

Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease

2001 • 111 citations

Acetylcholine release from rat cortical slices during postnatal development and aging

1983 • 109 citations

Anti‐inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia

2001 • 109 citations

τ Protein from Alzheimer's Disease Patients Is Glycated at Its Tubulin‐Binding Domain

1995 • 107 citations

Accumulation of advanced glycation end products of the Maillard reaction with age in human hippocampal neurons

1996 • 101 citations

Ischemia and the aging brain. Studies on glucose and energy metabolism in rat cerebral cortex

1986 • 100 citations

Aging, memory, and the cholinergic system: A study of dichotic listening☆

1980 • 100 citations

Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias.

1990 • 100 citations

Mechanisms of Protection against Damage Mediated by the Maillard Reaction in Aging

1991 • 88 citations

Noncompetitive NMDA Receptor Antagonists with Fast Open-Channel Blocking Kinetics and Strong Voltage-Dependency as Potential Therapeutic Agents for Alzheimer's Dementia

1995 • 87 citations

The effect of age on glucose and energy metabolism in brain cortex of rats

1985 • 86 citations

Microglial activation induces cell death, inhibits neurite outgrowth and causes neurite retraction of differentiated neuroblastoma cells

2003 • 83 citations

No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use

2000 • 81 citations

Cerebral Metabolism of Isotopic Glucose in Normal Human Subjects

1957 • 80 citations

Advanced glycation endproducts stimulate the MAP‐kinase pathway in tubulus cell line LLC‐PK₁

1997 • 77 citations

Lack of Pharmacokinetic or Pharmacodynamic Interaction Between Memantine and Donepezil

2004 • 76 citations

Selective alteration of mouse brain neurotransmitter release with age

1987 • 76 citations

Aspartate and glutamate induced reductions in extracellular free calcium and sodium concentration in area CA1 of ‘in vitro’ hippocampal slices of rats

1983 • 71 citations

N-methyl-d-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease

1992 • 70 citations

The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation

1994 • 70 citations

Ionotropic Glutamate Receptors as Therapeutic Targets

2004 • 68 citations

Cerebral metabolism of doubly labeled glucose in humans in vivo

1965 • 66 citations

Age-dependent accumulation of advanced glycosylation end products in human neurons

1995 • 66 citations

Functional Neurochemistry of Alzheimers Disease

2004 • 65 citations

Receptors coupled to ionic channels: the glutamate receptor family

1991 • 61 citations

A glycation connection

1994 • 60 citations

Brain glucose and energy metabolism during normal aging

1990 • 54 citations

A glutamatergic innervation of the nucleus basalis/substantia innominata

1984 • 51 citations

Der Aminos�uren-Stoffwechsel des normalen menschlichen Gehirns

1970 • 48 citations

Advanced glycation endproducts change glutathione redox status in SH-SY5Y human neuroblastoma cells by a hydrogen peroxide dependent mechanism

2001 • 47 citations

Glucose and amino acid metabolism in rat brain during sustained hypoglycemia

1983 • 46 citations

Increased [3H]glutamate receptor binding in aged rats

1981 • 46 citations

Nitric oxide synthase immunoreactivity in the rat dura mater

1994 • 41 citations

Neurotransmission and the ontogeny of human brain

1996 • 39 citations

Retention of maze performance inversely correlates with N-methyl-D-aspartate receptor number in hippocampus and frontal neocortex in the rat.

1989 • 32 citations

Retention of maze performance inversely correlates with N-methyl-D-aspartate receptor number in hippocampus and frontal neocortex in the rat.

1989 • 31 citations

Learning abilities depend on NMDA-receptor density in hippocampus in adult rats

1997 • 30 citations

Endogenous Excitotoxins as Possible Mediators of Ischemic and Hypoglycemic Brain Damage

1986 • 27 citations

Alois Alzheimer revisited: differences in origin of the disease carrying his name

2006 • 27 citations

Impairment of instrumental learning in rats by glutamic acid diethyl ester

1981 • 25 citations

Abnormalities in glucose and energy metabolism are more severe in the hippocampus than in cerebral cortex in postischemic recovery in aged rats

1988 • 25 citations

Glutamate neurotoxicity and Alzheimer's disease

1987 • 24 citations

P.4.017 Memantine/donepezil dual-therapy is superior to placebo/donepezil therapy for treatment of moderate to severe Alzheimer's disease

2003 • 21 citations

Effect of aging on cerebral cortex energy metabolism in hypoglycemia and posthypoglycemic recovery

1984 • 18 citations

Memantine inhibits [3H]MK-801 binding to human hippocampal NMDA receptors

1994 • 16 citations

Neurochemical abnormalities in Alzheimer’s disease and Parkinson’s disease — a comparative review

1997 • 16 citations

Pathomechanismen und hypothesengeleitete Therapieoptionen bei der Spätform der Alzheimer-Krankheit

2003 • 8 citations

Neue Aspekte in der antidementiven Pharmakotherapie der Alzheimer-Erkrankung

2000 • 5 citations

Aging, memory, and the cholinergic system: a study of dichotic listening.

1979 • 2 citations

Deleted Work

1955 • 0 citations