Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Developments of a water-maze procedure for studying spatial learning in the rat

1984 • 6,896 citations

Place navigation impaired in rats with hippocampal lesions

1982 • 6,277 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

Simple memory: a theory for archicortex

1971 • 2,722 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Memory and Brain

1987 • 1,821 citations

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

1985 • 1,294 citations

Hippocampal synaptic enhancement and information storage within a distributed memory system

1987 • 1,291 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

A memory system in the monkey

1982 • 1,137 citations

Parallel models of associative memory

1982 • 1,113 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

Non-Holographic Associative Memory

1969 • 1,009 citations

Long-term potentiation and NMDA receptors in rat visual cortex

1987 • 953 citations

Blockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex

1987 • 920 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors

1984 • 824 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

Agonists and antagonists for excitatory amino acid receptors

1987 • 692 citations

The hippocampal memory indexing theory.

1986 • 692 citations

The hippocampal memory indexing theory.

1986 • 682 citations

Synaptic enhancement in fascia dentata: Cooperativity among coactive afferents

1978 • 665 citations

Excitatory amino acids in the brain - focus on NMDA receptors

1987 • 641 citations

Heterosynaptic depression: a postsynaptic correlate of long-term potentiation

1977 • 606 citations

A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat

1983 • 590 citations

Associations across time: The hippocampus as a temporary memory store

1985 • 563 citations

Long-term potentiation phenomena in the rat limbic forebrain

1983 • 562 citations

Hebbian synapses in hippocampus.

1986 • 560 citations

Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

1985 • 558 citations

The current excitement in long term potentiation

1988 • 538 citations

A Physiological Basis for a Theory of Synapse Modification

1987 • 535 citations

Specific long-lasting potentiation of synaptic transmission in hippocampal slices

1977 • 493 citations

An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?

1985 • 457 citations

Studies of mind and brain

1982 • 456 citations

A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats.

1983 • 421 citations

Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism

1986 • 416 citations

An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.

1985 • 334 citations

Long-term enhancement of hippocampal synaptic transmission and the acquisition of spatial information

1986 • 325 citations

Learning and memory: regional changes in N-methyl-D-aspartate receptors in the chick brain after imprinting.

1988 • 298 citations

L-Glutamate has higher affinity than other amino acids for [3H]-D-AP5 binding sites in rat brain membranes

1984 • 293 citations

Receptors for the excitatory amino acids in the mammalian central nervous system

1983 • 292 citations

Place navigation in rats is impaired by lesions of medial septum and diagonal band but not nucleus basalis magnocellularis

1988 • 289 citations

Hippocampal long‐term potentiation is induced by pairing single afferent volleys with intracellular^ injected depolarizing current pulses

1986 • 284 citations

N‐methyl aspartate activates voltage‐dependent calcium conductance in rat hippocampal pyramidal cells.

1983 • 281 citations

Associative long-term potentiation in hippocampal slices.

1983 • 280 citations

An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses.

1985 • 275 citations

Allocentric spatial learning by hippocampectomised rats: a further test of the "spatial mapping" and "working memory" theories of hippocampal function.

1986 • 273 citations

Cholinergic receptor blockade in the rat impairs locale but not taxon strategies for place navigation in a swimming pool.

1985 • 270 citations

Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by d(−)aminophosphonovalerate

1987 • 269 citations

The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro

1987 • 268 citations

Anticonvulsant Drugs and Cognitive Functions

1982 • 244 citations

Role of excitatory amino acid receptors in mono- and polysynaptic excitation in the cat spinal cord

1983 • 243 citations

Disruption of central cholinergic systems in the rat by basal forebrain lesions or atropine: Effects on feeding, sensorimotor behaviour, locomotor activity and spatial navigation

1985 • 242 citations

Cholinergic receptor blockade in the rat impairs locale but not taxon strategies for place navigation in a swimming pool.

1985 • 242 citations

Intra-ventricular infusion of the NMDA antagonist AP5 impairs performance on a non-spatial operant DRL task in the rat

1988 • 225 citations

Hippocampal long-term potentiation: Mechanisms and implications for memory.

1982 • 195 citations

THE NEUROLOGY OF MEMORY: THE CASE FOR CORRESPONDENCE BETWEEN THE FINDINGS FOR HUMAN AND NONHUMAN PRIMATE

1983 • 174 citations

Selective Hippocampal Lesions and Behavior

1986 • 173 citations

The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats

1984 • 172 citations

Calcium in long-term potentiation as a model for memory

1983 • 164 citations

Selective increase in phosphorylation of a 47-kDa protein (F1) directly related to long-term potentiation

1985 • 152 citations

Postnatal development of bulk flow in the cerebrospinal fluid system of the albino rat: Clearance of carboxyl-[14C]inulin after intrathecal infusion

1973 • 150 citations

N-methyl-D-aspartate receptor antagonists reduce synaptic excitation in the hippocampus

1986 • 122 citations

Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus.

1983 • 120 citations

Synaptic plasticity and learning II: Do different kinds of plasticity underlie different kinds of learning?

1989 • 118 citations

Mental Effects of Antiepileptic Medication: A Review

1983 • 111 citations

Muscle relaxant action of excitatory amino acid antagonists

1985 • 100 citations

NMDA Receptors: what do they do?

1986 • 96 citations

Comparative aspects of studies of amnesia

1982 • 94 citations

APV, an N-methyl-d-aspartate receptor antagonist, blocks the hippocampal theta rhythm in behaving rats

1988 • 91 citations

A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats

1987 • 76 citations

Rate-Controlled Delivery Systems in Drug and Hormone Research

1984 • 72 citations

Ventriculo–cisternal perfusion of twelve amino acids in the rabbit

1982 • 64 citations

The rat ventromedial thalamic nucleus and motor control: role of N- methyl-D-aspartate-mediated excitation, GABAergic inhibition, and muscarinic transmission

1986 • 42 citations

Stereotaxic mapping of brainstem areas critical for memory of visual discrimination habits in the rat

1976 • 37 citations

Long-term potentiation facilitates behavioral responding to single-pulse stimulation of the perforant path.

1985 • 19 citations

Monosynaptic activation of the hippocampus as a conditioned stimulus: Behavioral effects

1982 • 18 citations

N-methyl aspartate activates voltage-dependent calcium conductance in rat hippocampal pyramidal cells.

1983 • 14 citations

NMDA receptors: what do they do?

1986 • 10 citations

Learning: A step nearer a neural substrate

1986 • 7 citations

Rate-Controlled Delivery Systems in Drug and Hormone Research

1984 • 7 citations