Excitatory amino acid transmitters and their receptors in neural circuits of the cerebral neocortex

Handbook of Chemical Neuroanatomy

1986 • 4,276 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

The physiology of excitatory amino acids in the vertebrate central nervous system

1987 • 1,718 citations

Chemical Neuroanatomy

1984 • 1,646 citations

Kainic acid as a tool in neurobiology

1978 • 1,314 citations

Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

1985 • 1,294 citations

Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists

1988 • 1,202 citations

NMDA receptors - their role in long-term potentiation

1987 • 1,177 citations

Amino acid transmitters in the mammalian central nervous system

1974 • 1,169 citations

Long-term potentiation and NMDA receptors in rat visual cortex

1987 • 953 citations

Blockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex

1987 • 920 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

First visualization of glutamate and GABA in neurones by immunocytochemistry

1983 • 872 citations

THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDS

1960 • 853 citations

Glutamate‐ and GABA‐containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique

1984 • 851 citations

An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid

1982 • 834 citations

A new method for receptor autoradiography: [3H]Opioid receptors in rat brain

1979 • 797 citations

A new type of glutamate receptor linked to inositol phospholipid metabolism

1987 • 743 citations

THE STRUCTURAL SPECIFICITY OF THE HIGH AFFINITY UPTAKE OF <scp>l</scp>‐GLUTAMATE AND <scp>l</scp>‐ASPARTATE BY RAT BRAIN SLICES

1972 • 694 citations

Agonists and antagonists for excitatory amino acid receptors

1987 • 692 citations

Iontophoretic studies of neurones in the mammalian cerebral cortex

1963 • 659 citations

Amino acid neurotransmitters and their pathways in the mammalian central nervous system

1983 • 646 citations

Cytochemical methods in neuroanatomy

1982 • 560 citations

Biochemical evidence for glutamate as neurotransmitter in corticostriatal and corticothalamic fibres in rat brain

1981 • 547 citations

Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

1983 • 522 citations

A glutamatergic corticostriatal path?

1977 • 487 citations

Excitatory Amino Acid Neurotransmission: NMDA Receptors and Hebb-Type Synaptic Plasticity

1988 • 484 citations

The hyperpolarization of spinal motoneurones by glycine and related amino acids

1968 • 481 citations

The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography

1982 • 481 citations

High affinity uptake of glutamate in terminals of corticostriatal axons

1977 • 480 citations

2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation

1981 • 468 citations

Microcircuitry of the Visual Cortex

1983 • 458 citations

An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?

1985 • 457 citations

NMDA receptors in the visual cortex of young kittens are more effective than those of adult cats

1987 • 446 citations

Characterization of Glutamate Uptake into Synaptic Vesicles

1985 • 437 citations

Excitatory amino acid transmission

1987 • 430 citations

Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate

1979 • 423 citations

Acidic amino acids with strong excitatory actions on mammalian neurones

1963 • 415 citations

The effect on crayfish muscle of iontophoretically applied glutamate

1964 • 415 citations

Pharmacological characterization of different types of GABA and glutamate receptors in vertebrates and invertebrates☆☆☆

1979 • 392 citations

GLUTAMINE—A MAJOR SUBSTRATE FOR NERVE ENDINGS

1978 • 380 citations

The Cell surface and neuronal function

1980 • 379 citations

A review — critical for idenctification of a central nervous system transmitter

1966 • 379 citations

Measurement of neurotransmitter release in vivo

1985 • 374 citations

The antagonism of amino acid‐induced excitations of rat hippocampal CA1 neurones in vitro.

1983 • 360 citations

Antagonism of cortical excitation of striatal neurons by glutamic acid diethyl ester: Evidence for glutamic acid as an excitatory transmitter in the rat striatum

1976 • 343 citations

Anatomical organization of the primary visual cortex (area 17) of the cat. A comparison with area 17 of the macaque monkey

1979 • 339 citations

Distribution of putative neurotransmitters in the neocortex

1979 • 316 citations

UPTAKE AND RELEASE OF <scp>D</scp>‐ AND <scp>L</scp>‐ASPARTATE BY RAT BRAIN SLICES

1976 • 315 citations

The location and function of NMDA receptors in cat and kitten visual cortex

1989 • 310 citations

Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord

1983 • 307 citations

Effect of frontal cortex ablation on striatal glutamic acid level in rat

1977 • 306 citations

Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate

1989 • 297 citations

The cerebral cortex

1976 • 296 citations

Unique High Affinity Uptake Systems for Glycine, Glutamic and Aspartic Acids in Central Nervous Tissue of the Rat

1971 • 295 citations

Receptors for the excitatory amino acids in the mammalian central nervous system

1983 • 292 citations

Actions of several anthelmintics and insecticides on rat cortical neurones

1970 • 266 citations

Chemical Excitation of Spinal Neurones

1959 • 266 citations

Selective retrograde labeling indicating the transmitter of neuronal pathways

1980 • 249 citations

A magnesium‐sensitive post‐synaptic potential in rat cerebral cortex resembles neuronal responses to N‐methylaspartate.

1986 • 249 citations

Glutamic acid as a synaptic transmitter in the nervous system. A review

1972 • 243 citations

Excitation of mammalian central neurones by acidic amino acids

1972 • 239 citations

EFFECTS OF SODIUM GLUTAMATE ON THE NERVOUS SYSTEM

1954 • 235 citations

Actions of glutamic acid on spinal neurones

1973 • 234 citations

Excitatory amino acid synaptic mechanisms and neurological function

1986 • 231 citations

Distribution of [3H]AMPA binding sites in rat brain as determined by quantitative autoradiography

1984 • 229 citations

The excitation of Renshaw cells by pharmacological agents applied electrophoretically

1958 • 228 citations

NMDA receptors and ligands in the vertebrate CNS

1988 • 226 citations

The Binding of [³H]AMPA, a Structural Analogue of Glutamic Acid, to Rat Brain Membranes

1982 • 223 citations

Aspartate and glutamate as possible neurotransmitters in the visual cortex

1981 • 217 citations

Glutamic acid and excitatory nerve endings: reduction of glutamic acid uptake after axotomy

1977 • 215 citations

Characterization of antisera to glutamate and aspartate.

1988 • 208 citations

Adenosine triphosphate-dependent uptake of glutamate into protein I-associated synaptic vesicles.

1983 • 206 citations

Synaptology of the Visual Cortex

1973 • 202 citations

Pharmacology of the corticocaudate excitatory postsynaptic potential in the cat: Evidence for its mediation by quisqualateor kainate-receptors

1985 • 201 citations

Selective antagonism of amino acid‐induced and synaptic excitation in the cat spinal cord.

1979 • 195 citations

Rate of release of amino acids from the cerebral cortex in the cat as affected by brainstem and thalamic stimulation

1969 • 194 citations

Long‐term potentiation and N‐methyl‐D‐aspartate receptors in the visual cortex of young rats.

1989 • 189 citations

Evidence for glutamate as a neurotransmitter in the corticofugal fibres to the dorsal lateral geniculate body and the superior colliculus in rats

1978 • 187 citations

Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors.

1989 • 185 citations

Effects of excitatory amino acids and their antagonists on membrane and action potentials of cat caudate neurones.

1983 • 182 citations

Glutamate release in vitro from corticostriatal terminals

1979 • 179 citations

Glutamate-positive neurons in the somatic sensory cortex of rats and monkeys

1987 • 176 citations

Voltage-dependent currents prolong single-axon postsynaptic potentials in layer III pyramidal neurons in rat neocortical slices

1988 • 166 citations

NMDA- and non-NMDA-receptor components of excitatory synaptic potentials recorded from cells in layer V of rat visual cortex

1988 • 164 citations

Glutamate receptor subtypes may be classified into two major categories: A study on Xenopus oocytes injected with rat brain mRNA

1989 • 163 citations

Immunohistochemical study of glutaminase‐containing neurons in the cerebral cortex and thalamus of the rat

1988 • 162 citations

Different neuronal localization of aspartate-like and glutamate-like immunoreactivities in the hippocampus of rat, guinea-pig and senegalese baboon (Papio papio), with a note on the distribution of γ-aminobutyrate

1985 • 162 citations

Amino Acids Released from the Cerebral Cortex in Relation to Its State of Activation

1965 • 158 citations

The antagonistic action of glutamic acid diethylester towards amino acid-induced and synaptic excitations of central neurones

1972 • 157 citations

Changes with aging in the levels of amino acids in rat CNS structural elements I. Glutamate and related amino acids

1989 • 154 citations

Effect of Motor and Premotor Cortex Ablation on Concentrations of Amino Acids, Monoamines, and Acetylcholine and on the Ultrastructure in Rat Striatum. A Confirmation of Glutamate as the Specific Cortico‐Striatal Transmitter

1982 • 153 citations

EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs

1989 • 153 citations

In Vitro Release of Endogenous Excitatory Sulfur‐Containing Amino Acids from Various Rat Brain Regions

1986 • 151 citations

The excitant amino acids glutamic and aspartic acid as transmitter candidates in the vertebrate central nervous system

1978 • 144 citations

In Vivo Release of Endogenous Amino Acids from the Rat Striatum: Further Evidence for a Role of Glutamate and Aspartate in Corticostriatal Neurotransmission

1986 • 144 citations

Decreased glutamate uptake in subcortical areas deafferented by sensorimotor cortical ablation in the cat

1981 • 138 citations

Excitatory Amino Acids

1986 • 135 citations

D-α-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones

1977 • 135 citations

Glutamate and Aspartate as Transmitter Candidates for Systems of the Cerebral Cortex

1984 • 133 citations

A new potent excitant, quisqualic acid: Effects on crayfish neuromuscular junction

1974 • 133 citations

Striatal glutamatergic function: Modifications following specific lesions

1982 • 133 citations

EPSPs in rat neocortical neurons in vitro. I. Electrophysiological evidence for two distinct EPSPs

1989 • 132 citations

The development of receptors in cat visual cortex

1989 • 130 citations

Glutamate in rat brain cortex synaptic vesicles: influence of the vesicle isolation procedure

1986 • 128 citations

Neurotransmitters and Cortical Function

1988 • 123 citations

The release of endogenous amino acids from the rat visual cortex.

1976 • 116 citations

Differentiation of kainate and quisqualate receptors in the cat spinal cord by selective antagonism with γ-D(and L)-glutamylglycine

1981 • 115 citations

Localization of glutaminase-like and aspartate aminotransferase-like immunoreactivity in neurons of cerebral neocortex

1985 • 115 citations

Mouse spinal cord in cell culture. III. Neuronal chemosensitivity and its relationship to synaptic activity

1977 • 112 citations

The antagonism of the glutamate-induced and synaptic excitations of thalamic neurones

1972 • 109 citations

Monoclonal antibody specific for carbodiimide-fixed glutamate: immunocytochemical localization in the rat CNS.

1986 • 108 citations

Glutamate-like immunoreactive structures in primary sensory neurons in the rat detected by a specific antiserum against glutamate

1987 • 108 citations

Quantitative immunogold analysis reveals high glutamate levels in retinal and cortical synaptic terminals in the lateral geniculate nucleus of the macaque

1989 • 105 citations

Pharmacology of the glutamate receptor

1988 • 103 citations

Selective retrograde transport of d-aspartate in spinal interneurons and cortical neurons of rats

1982 • 102 citations

Cortical pyramidal tract interneurones and their sensitivity to L‐glutamic acid

1973 • 99 citations

Aspartate aminotransferase-like immunoreactivity as a marker for aspartate/glutamate in guinea pig photoreceptors

1982 • 97 citations

The excitation of mammalian central neurones by amino acids.

1979 • 97 citations

Excitatory amino acid transmitters in neuronal circuits of the cat visual cortex

1986 • 96 citations

In Vivo Release from Cerebral Cortex of [¹⁴C]Glutamate Synthesized from [U‐¹⁴C]Glutamine

1983 • 94 citations

MICROELECTROPHORESIS

1964 • 91 citations

Production, characterization, and immunohistochemical application of monoclonal antibodies to glutaminase purified from rat brain

1987 • 90 citations

The pharmacology of synapses formed by identified corticocollicular neurons in primary cultures of rat visual cortex

1988 • 88 citations

The laminar distributions and postnatal development of neurotransmitter and neuromodulator receptors in cat visual cortex

1986 • 88 citations

Antagonism of Excitatory Amino Acid-Induced and Synaptic Excitation of Spinal Neurones by cis-2,3-Piperidine Dicarboxylate

1981 • 83 citations

Selective retrograde labeling with D‐[³H]‐aspartate in afferents to the mammalian superior colliculus

1985 • 81 citations

Localization of amino acid neurotransmitters by immunocytochemistry

1987 • 80 citations

A local circuit neocortical synapse that operates via both NMDA and non‐NMDA receptors

1989 • 80 citations

Specific calcium-dependent release of endogenous glutamate from rat striatum is reduced by destruction of the cortico-striatal tract

1980 • 80 citations

The history and development of microiontophoresis in experimental neurobiology

1984 • 80 citations

Actions of excitatory amino acid antagonists on synaptic potentials of layer II/III neurons of the cat's visual cortex

1989 • 78 citations

Glutamate-positive corticocortical neurons in the somatic sensory areas I and II of cats

1988 • 76 citations

Glutamate and aspartate immunoreactivity in corticospinal neurons of rats

1989 • 73 citations

Microelectrophoretic studies on the depressant action of HA-966 on chemically and synaptically excited neurones in the cat cerebral cortex and cuneate nucleus

1973 • 73 citations

Specific antibodies against aspartate and their immunocytochemical application in the rat brain

1986 • 71 citations

EFFECTS OF TETRODOTOXIN, CALCIUM AND MAGNESIUM ON THE RELEASE OF AMINO ACIDS FROM SLICES OF GUINEA‐PIG CEREBRAL CORTEX

1978 • 71 citations

Actions of excitatory amino acid antagonists on geniculo-cortical transmission in the cat's visual cortex

1988 • 71 citations

Interlaminar and lateral excitatory amino acid connections in the striate cortex of monkey

1989 • 71 citations

Retrograde transport of d-[3H]aspartate in thalamocortical neurones

1983 • 70 citations

D‐[³H]aspartate retrograde labelling of callosal and association neurones of somatosensory areas I and II of cats

1987 • 70 citations

Glutamate or aspartate as a possible neurotransmitter of cerebral corticofugal fibers in the monkey

1983 • 70 citations

DISTRIBUTION AND UPTAKE OF AMINO ACIDS IN VARIOUS REGIONS OF THE CAT BRAIN IN VITRO

1969 • 65 citations

AMINO ACIDS AS NEUROTRANSMITTERS OF CORTICOFUGAL NEURONES IN THE RAT: A COMPARISON OF GLUTAMATE AND ASPARTATE

1979 • 65 citations

Immunocytochemical localization of glutamate-, glutaminase- and aspartate aminotransferase-like immunoreactivity in the rat deep cerebellar nuclei

1986 • 65 citations

l-Homocysteic acid but not l-glutamate is an endogenous receptor preferring agonist in rat neocortical neurons in vitro

1987 • 64 citations

Co‐Localization of fixative‐modified glutamate and glutaminase in neurons of the spinal trigeminal nucleus of the rat: An immunohistochemical and immunoradiochemical analysis

1986 • 64 citations

Extracellular concentrations of aspartate and glutamate in rat neostriatum following chemical stimulation of frontal cortex

1989 • 63 citations

Distribution and stress-induced increase of glutamate and aspartate levels in discrete brain nuclei of rats

1986 • 62 citations

Evidence for glutamate as the neurotransmitter of corticothalamic and corticorubral pathways

1981 • 62 citations

Effect of Cortico-Striate Pathway Lesion on the Activities of Enzymes Involved in Synthesis and Metabolism of Amino Acid Neurotransmitters in the Striatum

1985 • 61 citations

Purification of specific antibody against aspartate and immunocytochemical localization of aspartergic neurons in the rat brain

1987 • 61 citations

Glutamate and aspartate immunoreactivity in cortico-cortical neurons of the sensorimotor cortex of rats

1989 • 61 citations

Excitatory amino acids mediate responses elicited in vitro by stimulation of cortical afferents to reticularis thalami neurons of the rat

1989 • 61 citations

THE SPONTANEOUS AND ELECTRICALLY EVOKED RELEASE, FROM SLICES OF GUINEA‐PIG CEREBRAL CORTEX, OF ENDOGENOUS AMINO ACIDS LABELLED VIA METABOLISM OF <scp>d</scp>‐[U‐¹⁴C]GLUCOSE

1978 • 61 citations

Chapter 1 Chemical transmission and Dale's principle

1986 • 60 citations

Kynurenic acid as an antagonist of hippocampal excitatory transmission

1984 • 60 citations

Aspartate-releasing nerve terminals in rat striatum possess D-2 dopamine receptors mediating inhibition of release.

1989 • 59 citations

Anatomy of Putative Glutamatergic Neurons

1988 • 58 citations

The release of labeledl-glutamic acid from rat neostriatum In vivo following stimulation of frontal cortex

1980 • 58 citations

Glutamate‐positive neurons and axon terminals in cat sensory cortex: A correlative light and electron microscopic study

1989 • 57 citations

Measurement of Neurotransmitter Release in vivo

1985 • 57 citations

Release of glutamate and aspartate from the visual cortex of the cat following activation of afferent pathways

1990 • 56 citations

Laminar differences in development of afferent innervation to striate cortex neurones in kittens

1982 • 56 citations

Excitatory transmitter amino acid‐containing neurons in the rat visual cortex: A light and electron microscopic immunocytochemical study

1989 • 54 citations

Blockade by amino acid antagonists of neuronal excitation mediated by the pyramidal tract.

1976 • 52 citations

Effects of area 17 ablation on neurotransmitter parameters in efferents to area 18, the lateral geniculate body, pulvinar and superior colliculus in the cat

1984 • 51 citations

Laminar distribution of receptors in monkey (Macaca fascicularis) geniculostriate system

1986 • 51 citations

Differential amino acid neurotransmitter release in rat neostriatum following lesioning of the cortico-striatal pathway

1982 • 50 citations

Regional glutamate levels in rat brain determined after microwave fixation

1976 • 50 citations

Actions of excitatory amino acids and kynurenic acid in the primate hippocampus: A preliminary study

1984 • 48 citations

Monoclonal antibodies specific for fixative-modified aspartate: immunocytochemical localization in the rat CNS

1987 • 45 citations

A new method for producing a specific and high titre antibody against glutamate using colloidal gold as a carrier

1986 • 43 citations

Neuropharmacological properties of electrophysiologically identified, visually responsive neurones of the posterior lateral suprasylvian area

1983 • 40 citations

Regional cortical glutamergic and aspartergic projections to the amygdala and thalamus of the rat

1983 • 39 citations

Aspartate and glutamate as synaptic transmitters of parallel visual cortical pathways

1985 • 38 citations

Immunocytochemical evidence for glutamatergic cortico-cortical connections in monkeys

1988 • 38 citations

The corticopontine projection: Axotomy-induced loss of high affinity l-glutamate and d-aspartate uptake, but not of γ-aminobutyrate uptake, glutamate decarboxylase or choline acetyltransferase, in the pontine nuclei

1983 • 36 citations

Amino acids and the synaptic pharmacology of granule cells in the dentate gyrus of the rat

1979 • 36 citations

D‐Aspartate Uptake and Release in the Guinea Pig Spinal Cord After Partial Ablation of the Cerebral Cortex

1988 • 34 citations

Contribution of quisqualate/ kainate and NMDA receptors to excitatory synaptic transmission in the rat's visual cortex

1990 • 34 citations

Neurochemical heterogeneity among corticofugal and callosal projections

1989 • 33 citations

The transmitter role of glutamate in nervous systems.

1987 • 32 citations

Biochemical evidence for glutamate and/or aspartate as neurotransmitters in fibers from the visual cortex to the lateral posterior thalamic nucleus (pulvinar) in rats

1987 • 29 citations

Failure to demonstrate retrograde labelling of cerebellar Purkinje cells after injection of [3H]GABA in Deiters' nucleus

1983 • 25 citations

N-methyl-d-aspartate receptors in the cortex and hippocampus of baboon (Papio anubis andPapio papio)

1989 • 25 citations

Peripheral sensory stimulation and the release of transmitter amino acids in vivo from specific regions of cerebral cortex

1979 • 23 citations

An analysis of the influence of membrane potential and metabolic poisoning with azide on the sodium pump in skeletal muscle.

1976 • 23 citations

Glutamate receptors and new glutamate agonists

1983 • 22 citations

Multiple reversal potentials for responses to L-glutamic acid

1981 • 21 citations

Antagonism of Synaptic Transmission in vivo: Contributions of Microiontophoresis

1983 • 21 citations

K+-evoked Ca2+-dependent release of d-[3H]aspartate from terminals of the cortico-pontine pathway

1981 • 20 citations

Regional distribution of γ-aminobutyrate and l-glutamate uptake into synaptic vesicles isolated from rat brain

1989 • 20 citations

Decreased Uptake and Release of D‐Aspartate in the Guinea Pig Spinal Cord After Partial Cordotomy

1985 • 20 citations

Selective Labeling of Visual Corpus Callosum Connections with Aspartate in Cat and Rat?

1989 • 17 citations

Glia–Neuronal Interrelationships in the Metabolism of Excitatory Amino Acids

1986 • 12 citations

d-[3H]aspartate retrograde labelling of association neurones in area SI of the cat

1986 • 10 citations

Electrophoretic application of acetylcholine to the two sides of the end-plate membrane.

1954 • 9 citations

Hemidecortication selectively alters release of glutamate in perfusates collected from cerebral cortex of unrestrained rats

1987 • 4 citations