AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING

1995 • 1,277 citations

Staging of Alzheimer-Related Cortical Destruction

1993 • 810 citations

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

1994 • 791 citations

Metals and neuroscience

2000 • 724 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose

1995 • 584 citations

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.

1998 • 505 citations

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1997 • 417 citations

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide

1995 • 401 citations

Advanced Glycation End Products in Alzheimer's Disease and Other Neurodegenerative Diseases

1998 • 389 citations

Advanced Glycation End Product-Induced Activation of NF-κB is Suppressed by α-Lipoic Acid in Cultured Endothelial Cells

1997 • 372 citations

Analysis of microtubule-associated protein tau glycation in paired helical filaments.

1994 • 326 citations

Advanced glycation end products up-regulate gene expression found in diabetic glomerular disease.

1994 • 298 citations

Advanced glycation end products: A nephrologist's perspective

2000 • 293 citations

Amadorins: Novel Post-Amadori Inhibitors of Advanced Glycation Reactions

1999 • 271 citations

Pyridoxamine, an Inhibitor of Advanced Glycation Reactions, Also Inhibits Advanced Lipoxidation Reactions

2000 • 245 citations

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimerʼs disease

1996 • 244 citations

Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive protein

1993 • 243 citations

Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease

1997 • 243 citations

Progression of Nephropathy in Spontaneous Diabetic Rats Is Prevented by OPB-9195, a Novel Inhibitor of Advanced Glycation

1997 • 229 citations

Accumulation of α-oxoaldehydes during oxidative stress: a role in cytotoxicity

1999 • 229 citations

The role of cell cycle‐mediated events in Alzheimer's disease

1999 • 220 citations

Redox metals and neu rodegenerative disease

1999 • 218 citations

Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor, OPB-9195

1999 • 213 citations

Non‐enzymatic glycosylation of the dipeptide <scp>l</scp>‐carnosine, a potential anti‐protein‐cross‐linking agent

1995 • 207 citations

Induction of cytokines in glial cells surrounding cortical β‐amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology

2000 • 198 citations

High molecular weight hyaluronic acid inhibits advanced glycation endproduct‐induced NF‐κB activation and cytokine expression

1999 • 195 citations

Thiamine Pyrophosphate and Pyridoxamine Inhibit the Formation of Antigenic Advanced Glycation End-Products: Comparison with Aminoguanidine

1996 • 191 citations

Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product

1998 • 186 citations

A Redox-triggered Ras-Effector Interaction

1998 • 182 citations

Microglial inter leukin‐1α expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution

1995 • 181 citations

Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of β-amyloid peptide

1997 • 171 citations

Carnosine, a protective, anti-ageing peptide?

1998 • 170 citations

Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the overexpression of tumour necrosis factor-α and inducible nitric oxide synthase in diabetic rat glomeruli

1999 • 150 citations

Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: Synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases

1999 • 146 citations

Cytotoxicity of advanced glycation endproducts is mediated by oxidative stress

1998 • 143 citations

Toxic effects of β-amyloid(25–35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and β-alanine

1998 • 136 citations

Immunohistochemical Localization of Advanced Glycation End Products, Pentosidine, and Carboxymethyllysine in Lipofuscin Pigments of Alzheimer's Disease and Aged Neurons

1997 • 133 citations

Upregulation of Mesangial Growth Factor and Extracellular Matrix Synthesis by Advanced Glycation End Products Via a Receptor-Mediated Mechanism

1997 • 129 citations

Transition Metals Bind to Glycated Proteins Forming Redox Active “Glycochelates”: Implications for the Pathogenesis of Certain Diabetic Complications

1998 • 127 citations

Advanced Glycation End Products Induce Expression of Vascular Endothelial Growth Factor by Retinal Müller Cells

1997 • 117 citations

Carnosine reacts with a glycated protein

2000 • 111 citations

Neurotoxicity of advanced glycation endproducts during focal stroke and neuroprotective effects of aminoguanidine.

1995 • 110 citations

Transition metal‐mediated glycoxidation accelerates cross‐linking of β‐amyloid peptide

2000 • 109 citations

τ Protein from Alzheimer's Disease Patients Is Glycated at Its Tubulin‐Binding Domain

1995 • 107 citations

Advanced Glycation Endproducts Stimulate Interleukin-6 Production by Human Bone-Derived Cells

1997 • 102 citations

The reaction of methylglyoxal with aminoguanidine under physiological conditions and prevention of methylglyoxal binding to plasma proteins

1994 • 96 citations

2‐Isopropylidenehydrazono‐4‐oxo‐thiazolidin‐5‐ylacetanilide (OPB‐9195) treatment inhibits the development of intimal thickening after balloon injury of rat carotid artery: role of glycoxidation and lipoxidation reactions in vascular tissue damage

1999 • 84 citations

RAGE-Abeta interactions in the pathophysiology of Alzheimer's disease.

1998 • 83 citations

α-Lipoic acid reduces expression of vascular cell adhesion molecule-1 and endothelial adhesion of human monocytes after stimulation with advanced glycation end products

1999 • 81 citations

Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?

1999 • 79 citations

Advanced glycation endproducts stimulate the MAP‐kinase pathway in tubulus cell line LLC‐PK₁

1997 • 77 citations

Glycation and microglial reaction in lesions of Alzheimer's disease

1996 • 77 citations

S100 proteins in Corpora Amylacea from normal human brain11Published on the World Wide Web on 5 May 2000.

2000 • 77 citations

Role of the Janus kinase (JAK)/signal transducters and activators of transcription (STAT) cascade in advanced glycation end-product-induced cellular mitogenesis in NRK-49F cells

1999 • 73 citations

Advanced glycation end products co-localized with astrocytes and microglial cells in Alzheimer's disease brain

1998 • 70 citations

The cognition-enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation

1994 • 70 citations

Age-dependent accumulation of advanced glycosylation end products in human neurons

1995 • 66 citations

An immunochemical study on tau glycation in paired helical filaments

1999 • 64 citations

The role of axonal cytoskeleton in diabetic neuropathy.

1997 • 64 citations

Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src

1999 • 63 citations

Enhanced binding of advanced glycation endproducts (AGE) by the ApoE4 isoform links the mechanism of plaque deposition in Alzheimer's disease

1997 • 63 citations

Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain

1996 • 61 citations

Rapid hydrolysis and slow α,β-dicarbonyl cleavage of an agent proposed to cleave glucose-derived protein cross-links

1999 • 59 citations

Inhibitory Effects of Tenilsetam on the Maillard Reaction

1997 • 59 citations

On the structure of microtubules, tau, and paired helical filaments

1995 • 58 citations

Synthesis and secretion of tumour necrosis factor-α by human monocytic THP-1 cells and chemotaxis induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts

1997 • 57 citations

Advanced glycation endproducts are associated with Hirano bodies in Alzheimer's disease

1998 • 57 citations

Localization of identified advanced glycation end‐product structures, Nε=(carboxymethyl)lysine and pentosidine, in age‐related inclusions in human brains

1998 • 50 citations

Advanced Glycation Endproducts–Receptor Interactions Stimulate the Growth of Human Pancreatic Cancer Cells through the Induction of Platelet-Derived Growth Factor-B

1996 • 48 citations

Synthesis and secretion of macrophage colony stimulating factor by mature human monocytes and human monocytic THP-1 cells induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts

1996 • 46 citations

The role of the Maillard reaction in other pathologies: Alzheimer's disease

1996 • 39 citations

Fructose-3-phosphate production and polyol pathway metabolism in diabetic rat hearts

1997 • 34 citations

Carnosine prevents glyceraldehyde 3-phosphate-mediated inhibition of aspartate aminotransferase

1999 • 29 citations

Tau glycation is involved in aggregation of the protein but not in the formation of filaments.

1998 • 25 citations

Neuropathology of diabetic neuropathy and its correlations with neurophysiology.

1997 • 18 citations

Effects of 3 months treatment with tenilsetam in patients suffering from dementia of Alzheimer type (DAT)

1989 • 17 citations

MODEL STUDIES OF THE MAILLARD REACTION OF ARG-LYS WITH D-GLUCOSE

1999 • 2 citations

Deleted Work

1955 • 0 citations