Brain glucose and energy metabolism during normal aging

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

Observations on the brains of demented old people

1970 • 2,066 citations

The aging process.

1981 • 1,871 citations

Cell Damage in the Brain: A Speculative Synthesis

1981 • 1,827 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Brain energy metabolism

1978 • 1,448 citations

Selective stabilisation of developing synapses as a mechanism for the specification of neuronal networks

1976 • 1,444 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

1985 • 941 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

ATP and Brain Function

1989 • 812 citations

Regulation in metabolism

1973 • 780 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

Glutamate activates multiple single channel conductances in hippocampal neurons

1987 • 691 citations

Neocortical cell counts in normal human adult aging

1987 • 676 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, X. REGULATION OF THE ACTIVITY OF THE PYRUVATE DEHYDROGENASE COMPLEX FROM BEEF KIDNEY MITOCHONDRIA BY PHOSPHORYLATION AND DEPHOSPHORYLATION

1969 • 669 citations

Observations on the brains of non-demented old people

1968 • 656 citations

Neurotransmitter-related enzymes in senile dementia of the alzheimer type

1979 • 638 citations

Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex

1955 • 624 citations

Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.

1986 • 528 citations

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

1986 • 525 citations

Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

1983 • 522 citations

Regulation of Glucose Uptake by Muscle

1962 • 484 citations

Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions

1984 • 446 citations

The Molecular Mechanism of Insulin Action

1985 • 424 citations

Oxygen radicals stimulate intracellular proteolysis and lipid peroxidation by independent mechanisms in erythrocytes.

1987 • 414 citations

Brain energy metabolism

1979 • 400 citations

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

1988 • 392 citations

Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man.

1967 • 372 citations

ARTERIAL AND CEREBRAL VENOUS BLOOD

1942 • 356 citations

Expression of the β-Nerve Growth Factor Gene in Hippocampal Neurons

1988 • 356 citations

THE LIPID COMPOSITION OF PURIFIED BOVINE BRAIN MYELIN*

1966 • 355 citations

α-KETO ACID DEHYDROGENASE COMPLEXES, XI. COMPARATIVE STUDIES OF REGULATORY PROPERTIES OF THE PYRUVATE DEHYDROGENASE COMPLEXES FROM KIDNEY, HEART, AND LIVER MITOCHONDRIA

1969 • 355 citations

The promoter of Alzheimer's disease amyloid A4 precursor gene.

1988 • 309 citations

Aspects of Free Radical Reactions in Biological Systems: Aging

1980 • 306 citations

Sustained Dendritic Gradients of Ca ²⁺ Induced by Excitatory Amino Acids in CA1 Hippocampal Neurons

1988 • 301 citations

Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents

1976 • 300 citations

Localization of nerve growth factor receptors in cholinergic neurons of the human basal forebrain

1986 • 289 citations

Cell counts in human cerebral cortex in normal adults throughout life using an image analysing computer

1980 • 267 citations

Coenzyme a-acetylating enzymes in Alzheimer's disease: Possible cholinergic ‘compartment’ of pyruvate dehydrogenase

1980 • 232 citations

Regulation of glucose uptake by muscle. 9. Effects of fatty acids and ketone bodies, and of alloxan-diabetes and starvation, on pyruvate metabolism and on lactate-pyruvate and <scp>l</scp>-glycerol 3-phosphate-dihydroxyacetone phosphate concentration ratios in rat heart and rat diaphragm muscles

1964 • 226 citations

Excitatory amino acid-induced release of 3H-GABA from cultured mouse cerebral cortex interneurons

1987 • 224 citations

Aging Decreases Oxidative Metabolism and the Release and Synthesis of Acetylcholine

1981 • 215 citations

Energy‐Metabolising Enzymes in Brain Regions of Adult and Aging Rats

1981 • 212 citations

The role of calcium regulation in brain aging: reexamination of a hypothesis

1989 • 211 citations

Reduced ATP concentration as a basis for synaptic transmission failure during hypoxia in the in vitro guinea‐pig hippocampus

1982 • 208 citations

CEREBRAL METABOLISM IN ISCHAEMIA: NEUROCHEMICAL BASIS FOR THERAPY

1985 • 206 citations

Enhancement of Iron-Catalyzed Free Radical Formation by Acidosis in Brain Homogenates: Difference in Effect by Lactic Acid and CO₂

1989 • 201 citations

Aging and brain enzymes

1971 • 195 citations

Lesions to Schaffer collaterals prevent ischemic death of CA1 pyramidal cells

1986 • 193 citations

Biochemical evidence for glutamate as a transmitter in hippocampal efferents to the basal forebrain and hypothalamus in the rat brain

1980 • 192 citations

Age pigments, cell loss and hippocampal function

1979 • 170 citations

The localization and distribution of high affinity β-nerve growth factor binding sites in the central nervous system of the adult rat. A light microscopic autoradiographic study using [125I]β-nerve growth factor

1987 • 169 citations

Age-related alterations in neurotransmitter receptors: An electrophysiological and biochemical analysis

1981 • 167 citations

Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia

1987 • 164 citations

The significance of morphometric procedures in the investigation of age changes in cytoarchitectonic structures of human brain.

1984 • 163 citations

The Regulation of Metabolism

1973 • 161 citations

Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain.

1987 • 157 citations

Biochemistry of Dementia

1981 • 155 citations

SPECIFICITY AND KINETIC PROPERTIES OF MONOSACCHARIDE UPTAKE INTO GUINEA PIG CEREBRAL CORTEX IN VITRO

1971 • 153 citations

Induction of Brain Ornithine Decarboxylase During Recovery from Metabolic, Mechanical, Thermal, or Chemical Injury

1984 • 153 citations

EFFECTS OF AGEING ON LOCAL RATES OF CEREBRAL GLUCOSE UTILIZATION IN THE RAT

1980 • 139 citations

THE DENSITY OF NEURONS IN THE HUMAN HIPPOCAMPUS

1979 • 138 citations

Age-related changes of pyramidal cell basal dendrites in layers III and V of human motor cortex: A quantitative Golgi study

1985 • 137 citations

Der Kohlenhydratstoffwechsel des menschlichen Gehirns

1963 • 134 citations

CHEMICAL PATHOLOGY OF THE ORGANIC DEMENTIAS

1977 • 134 citations

Synthesis of Heat Shock Proteins in Rat Brain Cortex after Transient Ischemia

1986 • 129 citations

Age-related loss of nerve growth factor sensitivity in rat basal forebrain neurons

1988 • 128 citations

Hippocampal aging in rats: A morphometric study of multiple variables in semithin sections

1981 • 125 citations

Insulin increases glucose transfer across the blood-brain barrier in man.

1981 • 113 citations

Etiology of dementia of Alzheimer's type

1989 • 111 citations

Local Cerebral Glucose Utilization During Development and Aging of the Fischer‐344 Rat

1981 • 109 citations

Acetylcholine release from rat cortical slices during postnatal development and aging

1983 • 109 citations

Regional enzyme development in rat brain. Enzymes associated with glucose utilization

1984 • 104 citations

Temporal Profiles of Proteins Responsive to Transient Ischemia

1985 • 103 citations

Cerebral Synaptic Transmission During Anoxia Is Protected by Creatine

1981 • 100 citations

Ischemia and the aging brain. Studies on glucose and energy metabolism in rat cerebral cortex

1986 • 100 citations

Control of pyruvate dehydrogenase in the perfused rat heart by the intracellular concentration of acetyl-coenzyme A.

1964 • 99 citations

Response of Schaffer collateral-CA1 pyramidal cell synapses of the hippocampus to analogues of acidic amino acids

1982 • 98 citations

Chapter 14 Dendritic proliferation in the aging brain as a compensatory repair mechanism

1986 • 91 citations

Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

1985 • 89 citations

Stability of synaptic density and spine volume in dentate gyrus of aged rats

1983 • 88 citations

The effect of age on glucose and energy metabolism in brain cortex of rats

1985 • 86 citations

ANALYSIS OF THE PREFERENTIAL RELEASE OF NEWLY SYNTHESIZED ACETYLCHOLINE BY CORTICAL SLICES FROM RAT BRAIN WITH THE AID OF TWO DIFFERENT LABELLED PRECURSORS

1976 • 86 citations

THE TOPOGRAPHIC DISTRIBUTION OF SENILE PLAQUES AND NEUROFIBRILLARY TANGLES IN THE BRAINS OF NON‐DEMENTED PERSONS OF DIFFERENT AGES

1987 • 81 citations

Cerebral Metabolism of Isotopic Glucose in Normal Human Subjects

1957 • 80 citations

Dendritic extent in human CA2–3 hippocampal pyramidal neurons in normal aging and senile dementia

1987 • 79 citations

Selective alteration of mouse brain neurotransmitter release with age

1987 • 76 citations

Senile dementia and Alzheimer's disease. Brain blood flow and metabolism

1986 • 76 citations

Age-dependent Changes in the Oxidative Metabolism in Rat Brain

1977 • 76 citations

GABAA responses in hippocampal neurons are potentiated by glutamate

1989 • 75 citations

The structure and mechanism of neurotransmitter receptors. Implications for the structure and function of the central nervous system

1988 • 75 citations

Biochemistry of Dementia

1980 • 71 citations

ARTERIAL AND CEREBRAL VENOUS BLOOD

1942 • 71 citations

Aspartate and glutamate induced reductions in extracellular free calcium and sodium concentration in area CA1 of ‘in vitro’ hippocampal slices of rats

1983 • 71 citations

Phosphorylation‐Mediated Changes in Pyruvate Dehydrogenase Activity Influence Pyruvate‐Supported Calcium Accumulation by Brain Mitochondria

1981 • 68 citations

Cerebral metabolism of doubly labeled glucose in humans in vivo

1965 • 66 citations

Insulin stimulates choline acetyltransferase activity in cultured embryonic chicken retina neurons.

1987 • 65 citations

Chapter 12 Ratio of pyramidal cells versus non-pyramidal cells in the human frontal isocortex and changes in ratio with ageing and Alzheimer's disease

1986 • 64 citations

The effect of aging on the neuronal population within area 17 of adult rat cerebral cortex

1983 • 63 citations

THE REGULATION OF PYRUVATE DEHYDROGENASE IN BRAIN IN VIVO

1976 • 62 citations

MAJOR PATHWAYS OF GLUCOSE UTILIZATION IN THE BRAIN IN BRAIN PERFUSION EXPERIMENTS IN VIVO AND IN SITU*

1960 • 58 citations

STUDY ON THE INCORPORATION OF ¹⁴C DERIVED FROM GLUCOSE INTO THE FREE AMINO ACIDS OF THE BRAIN CORTEX*

1960 • 57 citations

Effect of Aging on the Metabolism of Pyruvate and 3‐Hydroxybutyrate in Nonsynaptic and Synaptic Mitochondria from Rat Brain

1980 • 56 citations

Do vasopressin-related peptides induce hippocampal corticosterone receptors? Implications for aging

1984 • 54 citations

Effects of aging and chronic arterial hypertension on the cell populations in the neocortex and archicortex of the rat

1982 • 54 citations

Release ofd-[3H]aspartate from the dorsolateral septum after electrical stimulation of the fimbria in vitro

1980 • 52 citations

A glutamatergic innervation of the nucleus basalis/substantia innominata

1984 • 51 citations

The evoked release of endogenous amino acids from tissue prisms of human neocortex

1983 • 51 citations

Spin label studies on synaptosomal membranes of rat brain cortex during aging

1983 • 49 citations

Age Dependence of the Level of the Enzymes Involved in the Protection against Active Oxygen Species in the Rat Brain

1987 • 48 citations

Der Aminos�uren-Stoffwechsel des normalen menschlichen Gehirns

1970 • 48 citations

Glucose and amino acid metabolism in rat brain during sustained hypoglycemia

1983 • 46 citations

Increased [3H]glutamate receptor binding in aged rats

1981 • 46 citations

The effect of age and lung pathology on cytochrome a,a3 redox levels in rat cerebral cortex

1978 • 44 citations

Synaptic atrophy in the senescent hippocampus

1979 • 43 citations

Aging in the rat olfactory system: Relative stability of piriform cortex contrasts with changes in olfactory bulb and olfactory epithelium

1985 • 42 citations

Cerebral Blood Flow and Oxidative Metabolism in Conscious Fischer‐344 Rats of Different Ages

1983 • 40 citations

Age-dependent Changes in the Oxygen Consumption of the Cerebral Cortex, Hypothalamus, Hippocampus, and Amygdaloid in Rats

1977 • 40 citations

Glutamate metabolism in ageing rat brain

1980 • 36 citations

Membrane fluidization increases low-affinity muscarinic receptor binding in brain: Changes with aging

1986 • 31 citations

[Senile dementia and Alzheimer's disease ].

1989 • 30 citations

The effect of increased longevity, produced by dietary restriction, on the neuronal population of area 17 in rat cerebral cortex

1987 • 30 citations

Lysosomal enzyme changes in young and aged control and entorhinal-lesioned rats

1983 • 29 citations

Stability of dendrites in cortical barrels of C57BL/6N mice between 4 and 45 months

1986 • 29 citations

Entorhinal Cortex Lesions Induce a Decreased Calcium Transport in Hippocampal Mitochondria

1982 • 28 citations

Endogenous Excitotoxins as Possible Mediators of Ischemic and Hypoglycemic Brain Damage

1986 • 27 citations

Age-related neurofilament phosphorylation in normal human brains

1989 • 27 citations

Conversion of glucose to neurotransmitter amino acids in the brains of young and aging rats

1980 • 26 citations

Abnormalities in glucose and energy metabolism are more severe in the hippocampus than in cerebral cortex in postischemic recovery in aged rats

1988 • 25 citations

Effect of aging on cerebral cortex energy metabolism in hypoglycemia and posthypoglycemic recovery

1984 • 18 citations

Morphology of the Human Isocortex in Young and Aged Individuals: Qualitative and Quantitative Findings1

2015 • 16 citations

Metabolic alterations in fiber layers of the CA 1 region of the gerbil hippocampus following short-term ischemia: High-energy phosphates, glucose-related metabolites, and amino acids

1988 • 16 citations

The Aging Brain. Neurological and Mental Disturbances.

1981 • 13 citations

Increased fragility of neuronal membranes with aging

1989 • 10 citations

Deleted Work

1955 • 0 citations