Molecular Dissection of the Nuclear Pore Complex

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

ZINC PROTEINS: Enzymes, Storage Proteins, Transcription Factors, and Replication Proteins

1992 • 966 citations

The nuclear lamina is a meshwork of intermediate-type filaments

1986 • 957 citations

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

Nuclear envelope permeability

1975 • 808 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Isolation of a protein that is essential for the first step of nuclear protein import

1994 • 710 citations

Functional Organization Of The Nuclear Envelope

1988 • 593 citations

Nuclear protein localization

1991 • 570 citations

Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

1988 • 551 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

Monoclonal antibodies identify a group of nuclear pore complex glycoproteins.

1987 • 533 citations

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

1995 • 511 citations

Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components.

1990 • 510 citations

Movement of a karyophilic protein through the nuclear pores of oocytes.

1984 • 510 citations

Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores.

1987 • 510 citations

A giant nucleopore protein that binds Ran/TC4

1995 • 492 citations

Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region

1995 • 471 citations

The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex

1995 • 460 citations

Architecture and design of the nuclear pore complex

1992 • 452 citations

Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

1995 • 430 citations

Nuclear pore complex glycoproteins contain cytoplasmically disposed O-linked N-acetylglucosamine.

1987 • 428 citations

Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy

1993 • 408 citations

Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.

1995 • 398 citations

Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.

1995 • 385 citations

THE NUCLEAR PORE COMPLEX

1995 • 383 citations

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

1992 • 377 citations

Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.

1992 • 370 citations

Peptidylproline cis‐trans‐isomerases: immunophilins

1993 • 349 citations

Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway.

1987 • 330 citations

Identification of a major polypeptide of the nuclear pore complex.

1982 • 326 citations

A large particle associated with the perimeter of the nuclear pore complex.

1982 • 314 citations

A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm

1993 • 308 citations

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins

1995 • 308 citations

Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope.

1994 • 306 citations

Isolation of the yeast nuclear pore complex.

1993 • 287 citations

Pores for thought: nuclear pore complex proteins

1994 • 286 citations

Protein Import into the Nucleus: An Integrated View

1995 • 277 citations

A human nucleoporin-like protein that specifically interacts with HIV Rev

1995 • 268 citations

Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

1993 • 261 citations

A new family of yeast nuclear pore complex proteins.

1992 • 256 citations

Toward a more complete 3-D structure of the nuclear pore complex

1991 • 254 citations

Nuclear localization signals (NLS).

1993 • 249 citations

Mechanisms of nuclear protein import

1995 • 241 citations

The human CAN protein, a putative oncogene productassociated with myeloid leukemogenesis, is a nuclear pore complex protein thatfaces the cytoplasm.

1994 • 238 citations

A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distribution.

1994 • 232 citations

A complex of nuclear pore proteins required for pore function.

1991 • 231 citations

Nuclear export signals and the fast track to the cytoplasm

1995 • 229 citations

Primary structure analysis of an integral membrane glycoprotein of the nuclear pore.

1989 • 228 citations

High resolution scanning electron microscopy of the nuclear envelope: demonstration of a new, regular, fibrous lattice attached to the baskets of the nucleoplasmic face of the nuclear pores.

1992 • 225 citations

Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast

1995 • 223 citations

A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail.

1990 • 222 citations

Intracellular migration of nuclear proteins in Xenopus oocytes

1978 • 221 citations

An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region

1993 • 220 citations

The NUP1 gene encodes an essential component of the yeast nuclear pore complex

1990 • 219 citations

Identification of specific binding proteins for a nuclear location sequence

1989 • 219 citations

Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex

1993 • 214 citations

A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic.

1993 • 211 citations

Identification of a Yeast Karyopherin Heterodimer That Targets Import Substrate to Mammalian Nuclear Pore Complexes

1995 • 210 citations

The nuclear and the cytoplasmic pore complex: structure, dynamics, distribution, and evolution.

1977 • 210 citations

A monoclonal antibody against the nuclear pore complex inhibits nucleocytoplasmic transport of protein and RNA in vivo.

1988 • 206 citations

Interactions and three-dimensional localization of a group of nuclear pore complex proteins.

1994 • 206 citations

The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factor.

1995 • 206 citations

Interactions and structure of the nuclear pore complex revealed by cryo-electron microscopy.

1989 • 193 citations

A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes.

1995 • 192 citations

Purification of NSP1 reveals complex formation with ‘GLFG’ nucleoporins and a novel nuclear pore protein NIC96.

1993 • 189 citations

Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry.

1991 • 185 citations

Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p.

1995 • 184 citations

RNA Export

1995 • 181 citations

NSP1: A yeast nuclear envelope protein localized at the nuclear pores exerts its essential function by its carboxy-terminal domain

1990 • 180 citations

A new subclass of nucleoporins that functionally interact with nuclear pore protein NSP1.

1992 • 172 citations

Functional interaction of Nic96p with a core nucleoporin complex consisting of Nsp1p, Nup49p and a novel protein Nup57p.

1995 • 167 citations

The nuclear pore complex

1993 • 166 citations

The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal.

1993 • 161 citations

Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants [published erratum appears in J Cell Biol 1994 Sep;126(6):1627]

1994 • 159 citations

A novel nucleoskeletal-like protein located at the nuclear periphery is required for the life cycle of Saccharomyces cerevisiae.

1988 • 156 citations

Visualization of transport-related configurations of the nuclear pore transporter

1990 • 156 citations

Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex.

1995 • 154 citations

Inhibition of nuclear accumulation of karyophilic proteins in living cells by microinjection of the lectin wheat germ agglutinin

1988 • 146 citations

Nup120p: a yeast nucleoporin required for NPC distribution and mRNA transport.

1995 • 146 citations

POM152 is an integral protein of the pore membrane domain of the yeast nuclear envelope.

1994 • 145 citations

NUP145 encodes a novel yeast glycine-leucine-phenylalanine-glycine (GLFG) nucleoporin required for nuclear envelope structure.

1994 • 140 citations

GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import.

1995 • 139 citations

The Essential Yeast Nucleoporin NUP159 Is Located on the Cytoplasmic Side of the Nuclear Pore Complex and Serves in Karyopherin-mediated Binding of Transport Substrate

1995 • 139 citations

Primary sequence and heterologous expression of nuclear pore glycoprotein p62.

1990 • 137 citations

Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif

1994 • 134 citations

Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene.

1995 • 133 citations

Intranuclear filaments containing a nuclear pore complex protein.

1993 • 131 citations

Reconstituted nuclei depleted of a vertebrate GLFG nuclear pore protein, p97, import but are defective in nuclear growth and replication.

1995 • 128 citations

Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.

1994 • 125 citations

Nuclear pore complex glycoprotein p62 of Xenopus laevis and mouse: cDNA cloning and identification of its glycosylated region.

1991 • 123 citations

NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex.

1993 • 119 citations

The single transmembrane segment of gp210 is sufficient for sorting to the pore membrane domain of the nuclear envelope.

1992 • 116 citations

Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex.

1994 • 114 citations

Molecular trafficking across the nuclear pore complex

1992 • 114 citations

A conditional yeast mutant deficient in mRNA transport from nucleus to cytoplasm.

1992 • 112 citations

Toward the molecular dissection of protein import into nuclei

1996 • 112 citations

Structural plasticity of the nuclear pore complex

1995 • 107 citations

Identification of a soluble precursor complex essential for nuclear pore assembly in vitro

1990 • 104 citations

Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization.

1991 • 104 citations

A novel nuclear pore protein Nup82p which specifically binds to a fraction of Nsp1p.

1995 • 102 citations

The nuclear pore complex: three-dimensional surface structure revealed by field emission, in-lens scanning electron microscopy, with underlying structure uncovered by proteolysis

1993 • 99 citations

Nuclear protein import is inhibited by an antibody to a lumenal epitope of a nuclear pore complex glycoprotein.

1992 • 98 citations

Mutation or deletion of the Saccharomyces cerevisiae RAT3/NUP133 gene causes temperature-dependent nuclear accumulation of poly(A)+ RNA and constitutive clustering of nuclear pore complexes.

1995 • 98 citations

Genetic approaches to nuclear pore structure and function

1995 • 98 citations

Monoclonal antibodies to a Mr 68000 pore complex glycoprotein interfere with nuclear protein uptake in Xenopus oocytes

1988 • 96 citations

Nuclear transport

1994 • 89 citations

Disruption of the nucleoporin gene NUP133 results in clustering of nuclear pore complexes.

1995 • 89 citations

Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA.

1993 • 89 citations

nup1 mutants exhibit pleiotropic defects in nuclear pore complex function.

1994 • 86 citations

A family of Ran binding proteins that includes nucleoporins.

1995 • 79 citations

Imaging nuclear pores of aldosterone-sensitive kidney cells by atomic force microscopy.

1994 • 78 citations

Purification and Characterization of a Nuclear Pore Glycoprotein Complex Containing p62

1993 • 73 citations

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

1995 • 70 citations

Nuclear Pore Complex Proteins

1996 • 67 citations

High-Resolution Field Emission Scanning Electron Microscope Imaging of Internal Cell Structures after Epon Extraction from Sections: A New Approach to Correlative Ultrastructural and Immunocytochemical Studies

1993 • 67 citations

NUP82 is an essential yeast nucleoporin required for poly(A)+ RNA export.

1995 • 66 citations

Protein export from the nucleus requires the GTPase Ran and GTP hydrolysis.

1995 • 65 citations

Towards understanding the three-dimensional structure of the nuclear pore complex at the molecular level

1994 • 65 citations

Nuclear membrane dynamics

1993 • 64 citations

In vitro translocation through the yeast nuclear envelope

1989 • 63 citations

Exploring nuclear pore complex structure and function in molecular detail

1995 • 60 citations

Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62.

1995 • 57 citations

NSP1 depletion in yeast affects nuclear pore formation and nuclear accumulation.

1992 • 53 citations

Role of different domains in the self-association of rat nucleoporin p62

1994 • 51 citations

Toward a Molecular Understanding of the Structure and Function of the Nuclear Pore Complex

1996 • 50 citations

Monoclonal antibodies prepared against the major Drosophila nuclear Matrix-pore complex-lamina glycoprotein bind specifically to the nuclear envelope in situ.

1985 • 48 citations

Nup180, a novel nuclear pore complex protein localizing to the cytoplasmic ring and associated fibrils.

1993 • 46 citations

The large C-terminal region of the integral pore membrane protein, POM121, is facing the nuclear pore complex.

1994 • 46 citations

Nup107 is a novel nuclear pore complex protein that contains a leucine zipper

1994 • 45 citations

Toward the Molecular Details of the Nuclear Pore Complex

1994 • 44 citations

Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153

1994 • 43 citations

Nucleocytoplasmic transport: factors and mechanisms

1995 • 38 citations

Structure and activation dynamics of RBL-2H3 cells observed with scanning force microscopy

1994 • 36 citations

Targeting of a cytosolic protein to the nuclear periphery.

1990 • 32 citations

Patch clamp and atomic force microscopy demonstrate TATA-binding protein (TBP) interactions with the nuclear pore complex

1995 • 30 citations

Direct interaction of nucleoporin p62 with mRNA during its export from the nucleus

1995 • 28 citations

Nucleotide sequence analysis of human tpr cDNA clones.

1992 • 28 citations

Exploring native nuclear pore complex structure and conformation by scanning force microscopy in physiological buffers

1994 • 26 citations

Nuclear Pores: David and Goliath in nuclear transport

1995 • 5 citations