The nuclear pore complex

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

ZINC PROTEINS: Enzymes, Storage Proteins, Transcription Factors, and Replication Proteins

1992 • 966 citations

The nuclear lamina is a meshwork of intermediate-type filaments

1986 • 957 citations

The nuclear envelope lamina is reversibly depolymerized during mitosis

1980 • 956 citations

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors.

1990 • 909 citations

Nuclear envelope permeability

1975 • 808 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Identification and characterization of a nuclear pore complex protein

1986 • 610 citations

Functional Organization Of The Nuclear Envelope

1988 • 593 citations

Nuclear protein localization

1991 • 570 citations

Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores

1988 • 551 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

Nuclear import can be separated into distinct steps in vitro: Nuclear pore binding and translocation

1988 • 535 citations

Monoclonal antibodies identify a group of nuclear pore complex glycoproteins.

1987 • 533 citations

Movement of a karyophilic protein through the nuclear pores of oocytes.

1984 • 510 citations

Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores.

1987 • 510 citations

Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components.

1990 • 510 citations

Architecture and design of the nuclear pore complex

1992 • 452 citations

Nuclear pore complex glycoproteins contain cytoplasmically disposed O-linked N-acetylglucosamine.

1987 • 428 citations

Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C

1990 • 425 citations

Sequence requirements for synthetic peptide-mediated translocation to the nucleus.

1989 • 413 citations

Monomethylated cap structures facilitate RNA export from the nucleus

1990 • 411 citations

Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy

1993 • 408 citations

Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear import

1991 • 391 citations

The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

1992 • 377 citations

RNA TRANSPORT FROM NUCLEUS TO CYTOPLASM IN CHIRONOMUS SALIVARY GLANDS

1966 • 361 citations

Phosphorylation of the nuclear lamins during interphase and mitosis.

1985 • 354 citations

The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate.

1992 • 335 citations

Nuclear pore complex contains a family of glycoproteins that includes p62: glycosylation through a previously unidentified cellular pathway.

1987 • 330 citations

Identification of a major polypeptide of the nuclear pore complex.

1982 • 326 citations

Nuclear export of different classes of RNA is mediated by specific factors

1994 • 323 citations

A large particle associated with the perimeter of the nuclear pore complex.

1982 • 314 citations

The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal

1990 • 309 citations

A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm

1993 • 308 citations

Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope.

1994 • 306 citations

Isolation of the yeast nuclear pore complex.

1993 • 287 citations

The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors

1992 • 278 citations

O-linked N-acetylglucosamine is attached to proteins of the nuclear pore. Evidence for cytoplasmic and nucleoplasmic glycoproteins.

1987 • 268 citations

A new family of yeast nuclear pore complex proteins.

1992 • 256 citations

Translocation of a specific premessenger ribonucleoprotein particle through the nuclear pore studied with electron microscope tomography

1992 • 254 citations

Toward a more complete 3-D structure of the nuclear pore complex

1991 • 254 citations

The human CAN protein, a putative oncogene productassociated with myeloid leukemogenesis, is a nuclear pore complex protein thatfaces the cytoplasm.

1994 • 238 citations

Structure and Function of the Nuclear Pore Complex

1992 • 237 citations

Structure, biochemistry, and functions of the nuclear envelope.

1974 • 237 citations

Nuclear import-export: In search of signals and mechanisms

1991 • 233 citations

A complex of nuclear pore proteins required for pore function.

1991 • 231 citations

Reconstitution of biochemically altered nuclear pores: Transport can be eliminated and restored

1990 • 228 citations

An Essential Signaling Role for the m ₃ G Cap in the Transport of U1 snRNP to the Nucleus

1990 • 228 citations

Primary structure analysis of an integral membrane glycoprotein of the nuclear pore.

1989 • 228 citations

High resolution scanning electron microscopy of the nuclear envelope: demonstration of a new, regular, fibrous lattice attached to the baskets of the nucleoplasmic face of the nuclear pores.

1992 • 225 citations

A major glycoprotein of the nuclear pore complex is a membrane-spanning polypeptide with a large lumenal domain and a small cytoplasmic tail.

1990 • 222 citations

An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region

1993 • 220 citations

The NUP1 gene encodes an essential component of the yeast nuclear pore complex

1990 • 219 citations

Identification of specific binding proteins for a nuclear location sequence

1989 • 219 citations

Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex

1993 • 214 citations

In vitro transport of a fluorescent nuclear protein and exclusion of non-nuclear proteins.

1986 • 211 citations

A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic traffic.

1993 • 211 citations

Protein import through the nuclear pore complex is a multistep process.

1989 • 208 citations

A monoclonal antibody against the nuclear pore complex inhibits nucleocytoplasmic transport of protein and RNA in vivo.

1988 • 206 citations

Interactions and three-dimensional localization of a group of nuclear pore complex proteins.

1994 • 206 citations

Protein-mediated nuclear export of RNA: 5S rRNA containing small RNPs in xenopus oocytes

1990 • 205 citations

tRNA transport from the nucleus in a eukaryotic cell: carrier-mediated translocation process.

1983 • 202 citations

Interactions and structure of the nuclear pore complex revealed by cryo-electron microscopy.

1989 • 193 citations

Nucleo-cytoplasmic transport of U snRNPs: definition of a nuclear location signal in the Sm core domain that binds a transport receptor independently of the m3G cap.

1993 • 189 citations

Purification of NSP1 reveals complex formation with ‘GLFG’ nucleoporins and a novel nuclear pore protein NIC96.

1993 • 189 citations

Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase.

1991 • 188 citations

Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry.

1991 • 185 citations

Antibodies against 70-kD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins.

1992 • 176 citations

Cloning and Characterization of SRP1, a Suppressor of Temperature-Sensitive RNA Polymerase I Mutations, in Saccharomyces cerevisiae

1992 • 175 citations

A new subclass of nucleoporins that functionally interact with nuclear pore protein NSP1.

1992 • 172 citations

The amino-terminal domain of the lamin B receptor is a nuclear envelope targeting signal.

1993 • 161 citations

A novel nucleoskeletal-like protein located at the nuclear periphery is required for the life cycle of Saccharomyces cerevisiae.

1988 • 156 citations

Visualization of transport-related configurations of the nuclear pore transporter

1990 • 156 citations

A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs.

1992 • 150 citations

Inhibition of nuclear accumulation of karyophilic proteins in living cells by microinjection of the lectin wheat germ agglutinin

1988 • 146 citations

POM152 is an integral protein of the pore membrane domain of the yeast nuclear envelope.

1994 • 145 citations

The ultrastructure of the nuclear envelope of amphibian oocytes: a reinvestigation I. The mature oocyte

1970 • 141 citations

NUP145 encodes a novel yeast glycine-leucine-phenylalanine-glycine (GLFG) nucleoporin required for nuclear envelope structure.

1994 • 140 citations

Primary sequence and heterologous expression of nuclear pore glycoprotein p62.

1990 • 137 citations

Cytoplasmic transport of ribosomal subunits microinjected into the Xenopus laevis oocyte nucleus: a generalized, facilitated process.

1990 • 135 citations

Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motif

1994 • 134 citations

Spontaneous assembly of pore complex-containing membranes ("annulate lamellae") in Xenopus egg extract in the absence of chromatin.

1991 • 133 citations

A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro.

1991 • 133 citations

Intranuclear filaments containing a nuclear pore complex protein.

1993 • 131 citations

An N-ethylmaleimide-sensitive cytosolic factor necessary for nuclear protein import: requirement in signal-mediated binding to the nuclear pore.

1990 • 128 citations

Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.

1994 • 125 citations

The ultrastructure of the nuclear envelope of amphibian oocytes: a reinvestigation

1970 • 124 citations

Nuclear pore complex glycoprotein p62 of Xenopus laevis and mouse: cDNA cloning and identification of its glycosylated region.

1991 • 123 citations

Export of mRNA from microinjected nuclei of Xenopus laevis oocytes.

1992 • 121 citations

Light and electron microscopy of Rat kangaroo cells in mitosis

1973 • 121 citations

NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex.

1993 • 119 citations

The single transmembrane segment of gp210 is sufficient for sorting to the pore membrane domain of the nuclear envelope.

1992 • 116 citations

Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex.

1994 • 114 citations

Molecular trafficking across the nuclear pore complex

1992 • 114 citations

Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway.

1991 • 105 citations

Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization.

1991 • 104 citations

Identification of a soluble precursor complex essential for nuclear pore assembly in vitro

1990 • 104 citations

The nuclear pore complex: three-dimensional surface structure revealed by field emission, in-lens scanning electron microscopy, with underlying structure uncovered by proteolysis

1993 • 99 citations

Nuclear protein import is inhibited by an antibody to a lumenal epitope of a nuclear pore complex glycoprotein.

1992 • 98 citations

Monoclonal antibodies to a Mr 68000 pore complex glycoprotein interfere with nuclear protein uptake in Xenopus oocytes

1988 • 96 citations

Microinjected U snRNAs are imported to oocyte nuclei via the nuclear pore complex by three distinguishable targeting pathways.

1992 • 93 citations

Transport of RNA between nucleus and cytoplasm

1992 • 93 citations

Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA.

1993 • 89 citations

Pathways for the nuclear transport of proteins and RNAs

1991 • 77 citations

Purification and Characterization of a Nuclear Pore Glycoprotein Complex Containing p62

1993 • 73 citations

In vitro nuclear import of snRNPs: cytosolic factors mediate m3G-cap dependence of U1 and U2 snRNP transport.

1994 • 70 citations

The nuclear pore complex and nucleocytoplasmic transport

1993 • 69 citations

O-linked glycoproteins of the nuclear pore complex interact with a cytosolic factor required for nuclear protein import.

1992 • 66 citations

Towards understanding the three-dimensional structure of the nuclear pore complex at the molecular level

1994 • 65 citations

Nuclear membrane dynamics

1993 • 64 citations

Role of different domains in the self-association of rat nucleoporin p62

1994 • 51 citations

The structure and interactions of components of nuclear envelopes from Xenopus oocyte germinal vesicles observed by heavy metal shadowing

1988 • 47 citations

Nup180, a novel nuclear pore complex protein localizing to the cytoplasmic ring and associated fibrils.

1993 • 46 citations

Nup107 is a novel nuclear pore complex protein that contains a leucine zipper

1994 • 45 citations

Sequence analysis of a cDNA encoding a human nuclear pore complex protein, hnup153

1994 • 43 citations

Nucleocytoplasmic transport and snRNP assembly

1993 • 38 citations

Nuclear pore structure and function

1992 • 32 citations

Targeting of a cytosolic protein to the nuclear periphery.

1990 • 32 citations

Nucleotide sequence analysis of human tpr cDNA clones.

1992 • 28 citations

Exploring native nuclear pore complex structure and conformation by scanning force microscopy in physiological buffers

1994 • 26 citations

Assembly of nuclear pore complexes in Xenopus egg extract

1991 • 26 citations

Structure and Function of the Nuclear Pore Complex

1992 • 13 citations

Molecular trafficking across the nuclear pore complex

1992 • 3 citations