Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA Receptor

EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis

1999 • 6,079 citations

The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses

2001 • 3,785 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1994 • 3,437 citations

The Medial Temporal Lobe Memory System

1991 • 3,239 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Hippocampal electrical activity and voluntary movement in the rat

1969 • 1,915 citations

Genetic enhancement of learning and memory in mice

1999 • 1,831 citations

Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae

2000 • 1,756 citations

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

1996 • 1,750 citations

Recognition memory: What are the roles of the perirhinal cortex and hippocampus?

2001 • 1,567 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1994 • 1,342 citations

Proteomic analysis of NMDA receptor–adhesion protein signaling complexes

2000 • 1,201 citations

Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity

2004 • 1,084 citations

Gene-expression profile of the ageing brain in mice

2000 • 1,057 citations

Calorie restriction, SIRT1 and metabolism: understanding longevity

2005 • 1,005 citations

Effects of Early and Late Nocturnal Sleep on Declarative and Procedural Memory

1997 • 998 citations

Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work group

1986 • 928 citations

Communication between neocortex and hippocampus during sleep in rodents

2003 • 924 citations

Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor ε1 subunit

1995 • 832 citations

Impact of aging on hippocampal function: plasticity, network dynamics, and cognition

2003 • 711 citations

Molecular mechanisms of memory acquisition, consolidation and retrieval

2001 • 696 citations

Calorie restriction and aging: review of the literature and implications for studies in humans

2003 • 691 citations

Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

2003 • 688 citations

NMDA Receptor Subunit Composition Controls Synaptic Plasticity by Regulating Binding to CaMKII

2005 • 685 citations

Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression

2004 • 678 citations

The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents

2007 • 651 citations

Caloric restriction and aging: an update

2000 • 616 citations

NR2A Subunit Expression Shortens NMDA Receptor Synaptic Currents in Developing Neocortex

1997 • 612 citations

Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo

1999 • 579 citations

Calorie Restriction, Aging, and Cancer Prevention: Mechanisms of Action and Applicability to Humans

2003 • 557 citations

Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse

1992 • 529 citations

Long-Term Plasticity of Intrinsic Excitability: Learning Rules and Mechanisms

2003 • 522 citations

Differential Roles of NR2A- and NR2B-Containing NMDA Receptors in Ras-ERK Signaling and AMPA Receptor Trafficking

2005 • 480 citations

Theta returns

2001 • 467 citations

Involvement of the CA3–CA1 Synapse in the Acquisition of Associative Learning in Behaving Mice

2006 • 454 citations

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

2002 • 449 citations

Subunit‐specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles

2005 • 415 citations

Identification of Proteins in the Postsynaptic Density Fraction by Mass Spectrometry

2000 • 399 citations

The N-methyl-d-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications

2002 • 360 citations

Aging in Rhesus Monkeys: Relevance to Human Health Interventions

2004 • 353 citations

Dietary Restriction Benefits Learning and Motor Performance of Aged Mice

1987 • 341 citations

Effects of early and late nocturnal sleep on priming and spatial memory

1999 • 337 citations

Formation of Temporal Memory Requires NMDA Receptors within CA1 Pyramidal Neurons

2000 • 335 citations

Differential effects of enrichment on learning and memory function in NR2B transgenic mice

2001 • 324 citations

Molecular machines integrate coincident synaptic signals

1993 • 310 citations

Calorie Restriction in Biosphere 2: Alterations in Physiologic, Hematologic, Hormonal, and Biochemical Parameters in Humans Restricted for a 2-Year Period

2002 • 301 citations

Lack of NMDA Receptor Subtype Selectivity for Hippocampal Long-Term Potentiation

2005 • 301 citations

Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms

2003 • 290 citations

Effect of Age and Caloric Intake on Protein Oxidation in Different Brain Regions and on Behavioral Functions of the Mouse

1996 • 290 citations

A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin

2004 • 270 citations

On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory

2007 • 268 citations

Increased Thresholds for Long-Term Potentiation and Contextual Learning in Mice Lacking the NMDA-type Glutamate Receptor ε1 Subunit

1998 • 241 citations

Glutamate Receptors in Perirhinal Cortex Mediate Encoding, Retrieval, and Consolidation of Object Recognition Memory

2005 • 211 citations

The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans.

1992 • 209 citations

Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice

2002 • 203 citations

Linking Hebb's coincidence-detection to memory formation

2000 • 202 citations

Development of Calorie Restriction Mimetics as a Prolongevity Strategy

2004 • 199 citations

Caloric restriction prevents age-related deficits in LTP and in NMDA receptor expression

2000 • 193 citations

Intracellular Domains of NMDA Receptor Subtypes Are Determinants for Long-Term Potentiation Induction

2003 • 182 citations

NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses

2001 • 181 citations

Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice

2002 • 179 citations

The effects of life-long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and the Morris water mazes

1989 • 178 citations

Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms

2001 • 174 citations

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing

2007 • 171 citations

The retardation of aging by caloric restriction: its significance in the transgenic era

2003 • 160 citations

Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk

1999 • 146 citations

VDCCs and NMDARs Underlie Two Forms of LTP in CA1 Hippocampus In Vivo

1999 • 140 citations

Deterioration of spatial and nonspatial reference and working memory in aged rats: Protective effect of life-long calorie restriction

1992 • 138 citations

The Different Effects on Recognition Memory of Perirhinal Kainate and NMDA Glutamate Receptor Antagonism: Implications for Underlying Plasticity Mechanisms

2006 • 107 citations

Lessons learned from gene expression profile studies of aging and caloric restriction

2004 • 104 citations

Introduction

2003 • 102 citations

Acquisition, Consolidation, Reconsolidation, and Extinction of Eyelid Conditioning Responses RequireDe NovoProtein Synthesis

2005 • 100 citations

Hippocampal Pyramidal Cell Activity Encodes Conditioned Stimulus Predictive Value During Classical Conditioning in Alert Cats

2001 • 99 citations

Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk

1999 • 93 citations

Dietary restriction: effects on radial maze learning and lipofuscin pigment deposition in the hippocampus and frontal cortex

1987 • 93 citations

A temporally distinct role for group I and group II metabotropic glutamate receptors in object recognition memory

2006 • 87 citations

Blockade of NR2B-Containing NMDA Receptors Prevents BDNF Enhancement of Glutamatergic Transmission in Hippocampal Neurons

1999 • 85 citations

Calorie Restriction in Obesity: Prevention of Kidney Disease in Rodents

2001 • 79 citations

Changes in Plasma Lipids and Lipoproteins in Humans During a 2-Year Period of Dietary Restriction in Biosphere 2

1998 • 79 citations

Analgesia Induced by Dietary Restriction Is Mediated by the κ-Opioid System

2003 • 62 citations

Requirement of NMDA receptor reactivation for consolidation and storage of nondeclarative taste memory revealed by inducible NR1 knockout

2005 • 59 citations

An in vitro and in vivo study of early deficits in associative learning in transgenic mice that over‐express a mutant form of human APP associated with Alzheimer's disease

2004 • 51 citations

Effects of early and late nocturnal sleep on priming and spatial memory

1999 • 50 citations

Brain-derived neurotrophic factor enhances association of protein tyrosine phosphatase PTP1D with the NMDA receptor subunit NR2B in the cortical postsynaptic density

1999 • 48 citations

The effect of NMDA-NR2B receptor subunit over-expression on olfactory memory task performance in the mouse

2004 • 41 citations

Contribution of NMDA receptor NR2B subunit to synaptic plasticity during associative learning in behaving rats

2007 • 35 citations

Amelioration of Age-Related Deficits in the Stimulation of Synapsin Phosphorylation

1997 • 21 citations

Chapter 10 Food Restriction and Brain Aging

1997 • 15 citations

Effect of lifelong hypocaloric diet on discrete memory of the senescent rat

1991 • 15 citations

Age-associated memory impairment

2000 • 9 citations