Calorie Restriction, Aging, and Cancer Prevention: Mechanisms of Action and Applicability to Humans

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

2002 • 18,132 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1935 • 2,189 citations

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

1998 • 1,850 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

2001 • 1,583 citations

Effects of Human Growth Hormone in Men over 60 Years Old

1990 • 1,560 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Gene Expression Profile of Aging and Its Retardation by Caloric Restriction

1999 • 1,483 citations

Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression

2000 • 1,414 citations

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

2001 • 1,398 citations

The Somatomedin Hypothesis: 2001

2001 • 1,184 citations

Leptin regulates proinflammatory immune responses

1998 • 1,161 citations

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

1999 • 1,128 citations

Gene-expression profile of the ageing brain in mice

2000 • 1,057 citations

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

1986 • 968 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

Balancing Life-Style and Genomics Research for Disease Prevention

2002 • 847 citations

Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah

1998 • 815 citations

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

2001 • 814 citations

Insulin-like growth factors and cancer

1992 • 622 citations

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

2000 • 613 citations

Insulin-Like Growth Factor 1 and Prostate Cancer Risk: A Population-Based, Case-Control Study

1998 • 592 citations

Life Span Study of SPF Fischer 344 Male Rats Fed AdLibitum or Restricted Diets: Longevity, Growth, Lean Body Mass and Disease

1982 • 573 citations

Effects of diet restriction on life span and age-related changes in dogs

2002 • 569 citations

Genome-Wide Transcript Profiles in Aging and Calorically Restricted Drosophila melanogaster

2002 • 567 citations

Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis

1999 • 558 citations

Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice.

1997 • 432 citations

Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice

2001 • 421 citations

A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women.

2000 • 407 citations

A Genetic Pathway Conferring Life Extension and Resistance to UV Stress in Caenorhabditis elegans

1996 • 390 citations

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

2001 • 386 citations

The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

1995 • 385 citations

Insulin-like Growth Factors and Cancer

1995 • 321 citations

Bone Mass and the Risk of Breast Cancer among Postmenopausal Women

1997 • 287 citations

Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice

2000 • 280 citations

The Genesis and Growth of Tumors. II. Effects of Caloric Restriction per se

1942 • 277 citations

Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver.

1994 • 274 citations

A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

1998 • 274 citations

Behavioral Strategies of Individuals Who Have Maintained Long‐Term Weight Losses

1999 • 272 citations

Longevity and heavy metal resistance indaf‐2andage‐1long‐lived mutants ofCaenorhabditis elegans

2001 • 264 citations

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

1992 • 248 citations

Dietary Restriction and Aging

1993 • 248 citations

Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor.

1994 • 234 citations

Bone mineral density and risk of breast cancer in older women: the study of osteoporotic fractures. Study of Osteoporotic Fractures Research Group.

1996 • 233 citations

Impact of westernization on the nutrition of Japanese: Changes in physique, cancer, longevity and centenarians

1978 • 232 citations

Insulin-like Growth Factors and Bone: The Osteoporosis Connection

1994 • 229 citations

Caloric Restriction in Primates and Relevance to Humans

2001 • 227 citations

Prospective study of the antitumor efficacy of long‐term octreotide treatment in patients with progressive metastatic gastrinoma

2002 • 213 citations

The Snell dwarf mutation Pit1dw can increase life span in mice

2002 • 213 citations

The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans.

1992 • 209 citations

Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice

2002 • 203 citations

Calorie Restriction in Primates: Will It Work and How Will We Know?

1999 • 187 citations

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice

2000 • 183 citations

A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis.

1996 • 181 citations

A prospective study of plasma levels of insulin-like growth factor I (IGF-I) and IGF-binding protein-3, and colorectal cancer risk among men

2000 • 181 citations

Insulin/IGF signalling and ageing: seeing the bigger picture

2001 • 174 citations

Constitutive expression of insulin-like growth factor-1 in epidermal basal cells of transgenic mice leads to spontaneous tumor promotion.

2000 • 174 citations

The Initiation and Growth of Tumors. Introduction. I. Effects of Underfeeding.

1940 • 170 citations

Physical fitness, endurance training, and the growth hormone-insulin-like growth factor I system in adolescent females.

1996 • 170 citations

Gene expression profiling of aging using DNA microarrays

2002 • 167 citations

Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice.

1994 • 161 citations

Leptin and prostate cancer

2001 • 156 citations

Biological Effects of Dietary Restriction

1991 • 144 citations

Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 x C3H F1 mice.

1994 • 131 citations

Testosterone, Growth Hormone and IGF-I Responses to Acute and Chronic Resistive Exercise in Men Aged 55-70 Years

1995 • 130 citations

Net Energy Effects of Dietary Fat on Chemically Induced Mammary Carcinogenesis in F344 Rats<xref ref-type="fn" rid="FN2">2</xref>

1986 • 128 citations

Insulin-Like Growth Factors and Bone: The Osteoporosis Connection Revisited

1998 • 122 citations

Caloric restriction and 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in rats: alterations in circulating insulin, insulin-like growth factors I and II, and epidermal growth factor.

1989 • 116 citations

Effects of Growth Hormone and Insulin-Like Growth Factor-1 on Hepatocyte Antioxidative Enzymes

2002 • 112 citations

Caloric restriction as a mechanism mediating resistance to environmental disease.

1998 • 107 citations

Caloric Restriction in Primates

2001 • 107 citations

Effectiveness of insulin-like growth factor I receptor antisense strategy against Ewing's sarcoma cells

2002 • 105 citations

Apoptosis in the genesis and prevention of cancer.

1992 • 101 citations

The Dependence of the Genesis of Induced Skin Tumors on the Caloric Intake during Different Stages of Carcinogenesis

1944 • 101 citations

The growth hormone: insulin-like growth factor 1 axis is a mediator of diet restriction-induced inhibition of mononuclear cell leukemia in Fischer rats.

1993 • 91 citations

Caloric restriction and experimental carcinogenesis

1999 • 91 citations

Roles for insulin-like growth factor-1 in mediating the anti-carcinogenic effects of caloric restriction.

1999 • 88 citations

Life extension and stress resistance in Caenorhabditis elegans. modulated by the tkr-1 gene

1998 • 88 citations

Nutrition and Longevity in the Rat

1961 • 86 citations

Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II.

1996 • 85 citations

The effect of wartime conditions and the 1944–45 ‘Dutch Famine’ on recalled menarcheal age in participants of the DOM breast cancer screening project

1991 • 84 citations

The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans

2001 • 82 citations

The effect of exercise on plasma somatomedin-C/insulinlike growth factor I concentrations

1987 • 81 citations

Caloric Restriction and Toxicity

1995 • 75 citations

Prolonging the Life Span

1934 • 74 citations

Bone mineral density and risk of breast cancer in older women: the study of osteoporotic fractures. Study of Osteoporotic Fractures Research Group

1996 • 72 citations

Discovery of a Series of Nonpeptide Small Molecules That Inhibit the Binding of Insulin-like Growth Factor (IGF) to IGF-Binding Proteins

2001 • 72 citations

The anti-carcinogenic effects of dietary restriction: mechanisms and future directions

1999 • 70 citations

Calorie restriction induces a p53-independent delay of spontaneous carcinogenesis in p53-deficient and wild-type mice.

1997 • 69 citations

Lifetime Effects of Winter Supplemental Feed Level and Age at First Parturition on Range Beef Cows

1972 • 69 citations

Dietary restriction, cell proliferation and carcinogenesis: A preliminary study

1988 • 68 citations

Reduction in the incidence of radiation-induced tumors in rats after restriction of food intake.

1984 • 63 citations

Insulin-like growth factor-I and binding protein-3 in relation to childhood leukaemia

1999 • 62 citations

Association of insulin‐like growth‐factor‐I‐induced DNA synthesis with phosphorylation and nuclear exclusion of p53 in human breast cancer MCF‐7 cells

1993 • 62 citations

Physical fitness, endurance training, and the growth hormone-insulin- like growth factor I system in adolescent females

1996 • 62 citations

THE INITIATION AND GROWTH OF TUMORS

2009 • 57 citations

Influence of Fat Intake and Caloric Restriction on Bone in Aging Male Rats

1997 • 55 citations

Energy restriction, a useful intervention to retard human ageing? Results of a feasibility study.

1994 • 54 citations

Suppression of serum insulin-like growth factor-1 levels in breast cancer patients during adjuvant tamoxifen therapy

1993 • 51 citations

The influence of food intake on the development of diethylnitrosamine-induced liver tumours in mice

1987 • 46 citations

Glucocorticoid Mediation of Dietary Energy Restriction Inhibition of Mouse Skin Carcinogenesis

1999 • 45 citations

Prevention of spontaneous and radiation-induced tumors in rats by reduction of food intake.

1990 • 43 citations

Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis

2001 • 40 citations

Colorectal cancer: the role of dietary fat and caloric restriction

1993 • 40 citations

IGF‐1 and Prostate Cancer

2004 • 39 citations

Bone mineral density and endogenous hormones and risk of breast cancer in postmenopausal women (United States).

2001 • 37 citations

Effects of calorie restriction on thymocyte growth, death and maturation

2000 • 34 citations

Long-term effects of fenretinide, a retinoic acid derivative, on the insulin-like growth factor system in women with early breast cancer.

2001 • 33 citations

Sound silencing: the Sir2 protein and cellular senescence

2001 • 31 citations

Proliferation and differentiation of a human colon cancer cell line (CaCo2) is associated with significant changes in the expression and secretion of insulin-like growth factor (IGF) IGF-II and IGF binding protein-4: role of IGF-II

1996 • 27 citations

Caloric restriction and experimental carcinogenesis

1999 • 27 citations

p53-independent inhibition of nitric oxide generation by cancer preventive interventions in ex vivo mouse peritoneal macrophages

1998 • 25 citations

The effects of age and dietary restriction without nutritional supplementation on whole bone structural properties in C57BL/6J mice.

1999 • 25 citations

IGF-I and Prostate Cancer

1998 • 24 citations

Protection against Cancer by Energy Restriction: All Experimental Approaches Are Not Equal

2002 • 22 citations

Mitogenic factors accelerate later-age diseases: insulin as a paradigm

1998 • 17 citations

Effect of dietary restriction on induced hamster cheek pouch carcinogenesis

1981 • 15 citations

Disruption of insulin-like growth factor-1 signaling and down-regulation of cdc2 by SC-alphaalphadelta9, a novel small molecule antisignaling agent identified in a targeted array library.

1998 • 14 citations

Selective estrogen receptor modulators (SERMs) and retinoids in breast cancer chemoprevention

2002 • 13 citations

The Quartercentenary Lecture

1993 • 12 citations

EFFECTS OF INSULIN‐LIKE GROWTH FACTOR‐BINDING PROTEIN 2 AND AN IGF‐TYPE I RECEPTOR‐BLOCKING ANTIBODY ON APOPTOSIS IN HUMAN TERATOCARCINOMA CELLS IN VITRO

2001 • 8 citations

The Utility of Transgenic Mouse Models for Cancer Prevention Research

2003 • 4 citations

The Utility of Transgenic Mouse Models for Cancer Prevention Research

2010 • 3 citations

Insulin‐like growth factor‐I and binding protein‐3 in relation to childhood leukaemia

1999 • 3 citations