Chapter 10 Food Restriction and Brain Aging

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Protein Oxidation and Aging

1992 • 2,687 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

Longevity, senescence and the genome

1995 • 1,390 citations

Why Stress Is Bad for Your Brain

1996 • 1,302 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Prevalence of Diabetes and Impaired Glucose Tolerance and Plasma Glucose Levels in U.S. Population Aged 20–74 Yr

1987 • 1,072 citations

Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

1994 • 791 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

The origin and nature of ramified and amoeboid microglia: A historical review and current concepts

1993 • 682 citations

Time, cells, and aging

1962 • 553 citations

Brain Aging Correlates: Retardation by Hormonal-Pharmacological Treatments

1981 • 519 citations

Longevity, senescence, and the genome

1992 • 409 citations

GFAP mRNA increases with age in rat and human brain

1993 • 391 citations

Altered antigen expression of microglia in the aged rodent CNS

1993 • 355 citations

Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology.

1996 • 347 citations

Memory impaired aged rats: No loss of principal hippocampal and subicular neurons

1996 • 347 citations

Dietary Restriction Benefits Learning and Motor Performance of Aged Mice

1987 • 341 citations

Food, reproduction and L'ongevity: Is the extended lifespan of calorie‐restricted animals an evolutionary adaptation?

1989 • 318 citations

Dietary Restriction Alters Characteristics of Glucose Fuel Use

1992 • 304 citations

Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr

1987 • 287 citations

Expression of Heat Shock Protein 70 is Altered by Age and Diet at the Level of Transcription

1993 • 284 citations

Influences of Dietary Restriction and Age on Liver Enzyme Activities and Lipid Peroxidation in Mice

1987 • 280 citations

The microglial cell. A historical review

1995 • 277 citations

Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat

1989 • 251 citations

Protein oxidation associated with aging is reduced by dietary restriction of protein or calories.

1992 • 248 citations

Dietary Restriction and Aging

1993 • 248 citations

Pathologic Characterization of Brown Norway, Brown Norway x Fischer 344, and Fischer 344 x Brown Norway Rats With Relation to Age

1996 • 245 citations

Assessment of the Role of the Glucocorticoid System in Aging Processes and in the Action of Food Restriction

1991 • 245 citations

Influence of Age and Long-term Dietary Restriction on Plasma Insulin-like Growth Factor-1 (IGF-1), IGF-1 Gene Expression, and IGF-1 Binding Proteins

1991 • 237 citations

Expression of heat shock protein 70 is altered by age and diet at the level of transcription.

1993 • 237 citations

Glial Fibrillary Acidic Protein: Regulation by Hormones, Cytokines, and Growth Factors

1994 • 230 citations

An Emerging Hypothesis: Synergistic Induction of Aging by Free Radicals and Maillard Reactions

1992 • 220 citations

Patterns of Astroglial Hypertrophy and Neuronal Degeneration in the Hippocampus of Aged, Memory-deficient Rats

1977 • 219 citations

The Evolution of the Antiaging Action of Dietary Restriction: A Hypothesis

1996 • 196 citations

Effect of age-related lipid peroxidation on membrane fluidity and phospholipase A2: Modulation by dietary restriction

1992 • 190 citations

The Effect of Retardation of Growth Upon the Breeding Period and Duration of Life of Rats

1917 • 178 citations

The effects of life-long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and the Morris water mazes

1989 • 178 citations

Age‐Related Differences in Synaptosomal Peroxidative Damage and Membrane Properties

1991 • 174 citations

Activities of antioxidant enzymes in various tissues of male Fischer 344 rats are altered by food restriction.

1995 • 170 citations

Neuron atrophy during aging: programmed or sporadic?

1993 • 169 citations

Dopamine and Serotonin Systems in Human and Rodent Brain: Effects of Age and Neurodegenerative Disease

1987 • 167 citations

The free radical hypothesis of aging: An appraisal of the current status

1993 • 166 citations

Critical Evaluation of the Free Radical Theory of Aging

1996 • 165 citations

Hibernation and Longevity in the Turkish Hamster Mesocricetus brandti

1981 • 154 citations

Nuclear Factor κ B Functions as a Negative Regulator for the Rat Androgen Receptor Gene and NF- κ B Activity Increases during the Age-dependent Desensitization of the Liver

1995 • 148 citations

Genetic Effects on Aging

1990 • 147 citations

The influence of long-term potentiation on the spatial relationship between astrocyte processes and potentiated synapses in the dentate gyrus neuropil of rat brain

1991 • 147 citations

Brain synaptosomal aging: Free radicals and membrane fluidity

1995 • 147 citations

Aging, Metabolism, and Alzheimer Disease: Review and Hypotheses

1997 • 146 citations

Biological Effects of Dietary Restriction

1991 • 144 citations

Studies on lipid peroxidation and protein oxidation in the aging brain

1995 • 140 citations

Modulation of aging processes by dietary restriction

1994 • 140 citations

Effect of Dietary Restriction on Estrous Cyclicity and Follicular Reserves in Aging C57BL/6J Mice 1

1985 • 139 citations

Dietary Restriction Retards the Age-Associated Loss of Rat Striatal Dopaminergic Receptors

1981 • 138 citations

Deterioration of spatial and nonspatial reference and working memory in aged rats: Protective effect of life-long calorie restriction

1992 • 138 citations

Sp1 DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues.

1992 • 128 citations

Growth, ageing, chronic diseases, and life span in rats.

1943 • 123 citations

Increased Transcription of the Astrocyte Gene GFAP During Middle-Age is Attenuated by Food Restriction: Implications for the Role of Oxidative Stress

1997 • 121 citations

Decline in immediate early gene expression in gonadotropin-releasing hormone neurons during proestrus in regularly cycling, middle-aged rats.

1994 • 109 citations

Delayed loss of striatal dopamine receptors during aging of dietarily restricted rats

1984 • 107 citations

Hyperadrenocorticism, Attenuated Inflammation, and the Life-Prolonging Action of Food Restriction in Mice

1995 • 105 citations

Modulation of aging processes by dietary restriction

1995 • 102 citations

The effects of hypophysectomy and continuous food restriction, begun at ages 70 and 400 days, on collagen aging, proteinuria, incidence of pathology and longevity in the male rat

1980 • 100 citations

Enhanced cell proliferation and biosynthesis mediate improved wound repair in refed, caloric-restricted mice

1996 • 99 citations

Early Onset and Topographical Distribution of Hypertrophied Astrocytes in Hippocampus of Aging Rats: A Quantitative Study

1979 • 99 citations

Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase system

1989 • 97 citations

Effect of caloric restriction on the expression of heat shock protein 70 and the activation of heat shock transcription factor 1

1996 • 95 citations

Longevity in Fish: Some Ecological and Evolutionary Considerations

1987 • 95 citations

Hydrocortisone administration retards axon sprouting in the rat dentate gyrus

1980 • 90 citations

Life-long moderate caloric restriction prolongs reproductive life span in rats without interrupting estrous cyclicity: effects on the gonadotropin-releasing hormone/luteinizing hormone axis

1996 • 90 citations

Influence of Age and Long-Term Dietary Restriction on Enzymatically Mediated Crosslinks and Nonenzymatic Glycation of Collagen in Mice

1994 • 89 citations

Caloric restriction, aging, and antioxidant enzymes

1993 • 86 citations

Effect of age and dietary restriction on the expression of alpha 2u-globulin.

1987 • 85 citations

Elevated glucose 6-phosphate levels are associated with plasmid mutations in vivo.

1987 • 84 citations

Dietary calorie restriction in the Emory mouse: effects on lifespan, eye lens cataract prevalence and progression, levels of ascorbate, glutathione, glucose, and glycohemoglobin, tail collagen breaktime, DNA and RNA oxidation, skin integrity, fecundity, and cancer

1995 • 81 citations

Effects of Aging and Dietary Restriction on Tissue Protein Synthesis: Relationship to Plasma Insulin-like Growth Factor-1

1992 • 80 citations

Long-term potentiation is lost in aged rats but preserved by calorie restriction

1992 • 77 citations

Differential effects of advancing age on neurotransmitter cell loss in the substantia nigra and striatum of C57BL/6N mice

1990 • 73 citations

Stimulation-produced analgesia in rats: Assessment by two pain tests and correlation with self-stimulation

1980 • 71 citations

Dopamine D2, D3, and D4 receptor mRNA levels in rat brain and pituitary during aging

1994 • 69 citations

Oxidative inactivation of tyrosine hydroxylase in substantia nigra of aged rat

1996 • 69 citations

Moderate Caloric Restriction Alters the Subcellular Distribution of Somatostatin mRNA and Increases Growth Hormone Pulse Amplitude in Aged Animals

1995 • 67 citations

A Unifying Hypothesis To Explain the Retardation of Aging and Tumorigenesis by Caloric Restriction

1995 • 64 citations

Reactive oxygen species: relation to aging and neurotoxic damage.

1992 • 58 citations

Aging and food restriction: Effect on lipids of cerebral cortex

1991 • 56 citations

Effects of dietary restriction on radial-arm maze performance and flavor memory in aged rats

1989 • 56 citations

Age-dependent increases of DNA adducts (I-compounds) in human and rat brain DNA

1993 • 55 citations

Life-Long Dietary Restriction Attenuates Age-Related Increases in Hippocampal Glial Fibrillary Acidic Protein mRNA

1997 • 51 citations

Aging-related changes in rat striatal D2 receptor mRNA-containing neurons: a quantitative nonradioactive in situ hybridization study

1995 • 50 citations

Effects of long-term restricted feeding on radial maze performance by aged rats

1987 • 49 citations

Transcription supports age-related increases of GFAP gene expression in the male rat brain

1996 • 47 citations

Food restriction delays the age-related increase in GFAP mRNA in rat hypothalamus

1995 • 47 citations

Life-long dietary restriction affects striatally-mediated behavioral responses in aged rats

1983 • 44 citations

Growth hormone stimulates granulation tissue formation and insulin-like growth factor-I gene expression in wound chambers in the rat

1992 • 42 citations

Effects of intermittent feeding on neurochemical markers in aging rat brain

1985 • 41 citations

Decline in immediate early gene expression in gonadotropin-releasing hormone neurons during proestrus in regularly cycling, middle-aged rats

1994 • 40 citations

Growth hormone reverses impaired wound healing in protein-malnourished rats treated with corticosteroids

1992 • 33 citations

Biological Effects of Dietary Restriction

1990 • 31 citations

Evidence of a Glycemic Threshold for the Formation of Pentosidine in Diabetic Dog Lens but Not in Collagen

1996 • 30 citations

Changes in lipid composition of cortical synaptosomes from different age groups of mice

1984 • 30 citations

The costs of reproduction and dietary restriction: parallels between insects and mammals.

1993 • 29 citations

Effects of aging and caloric restriction on I-compounds in liver, kidney and white blood cell DNA of male Brown-Norway rats

1991 • 29 citations

Dietary restriction in humans: report on the Little Rock Conference on the value, feasibility, and parameters of a proposed study

1996 • 24 citations

Failure of dietary restriction to retard age-related neurochemical changes in mice

1992 • 23 citations

Moderate Caloric Restriction Prevents the Age-Related Decline in Growth Hormone Receptor Signal Transduction

1996 • 23 citations

Does Gene Expression Play Any Role in the Mechanism of the Antiaging Effect of Dietary Restriction?

1992 • 19 citations

Age-related changes in composition of transcription factor, AP-1 complex in the rat brain

1995 • 18 citations

Induction of γδ transposition in response to elevated glucose-6-phosphate levels

1991 • 17 citations

Evidence of a glycemic threshold for the formation of pentosidine in diabetic dog lens but not in collagen

1996 • 11 citations

Aging, Dietary Restriction, and Glucocorticoids: A Critical Review of the Glucocorticoid Hypothesis

1991 • 6 citations