Molecular machines integrate coincident synaptic signals

The organization of behavior

1988 • 8,668 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

The organization of behavior.

1950 • 6,879 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

A theory of cerebellar cortex

1969 • 3,204 citations

Glycine potentiates the NMDA response in cultured mouse brain neurons

1987 • 3,116 citations

Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones

1984 • 2,822 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Molecular diversity of the NMDA receptor channel

1992 • 1,354 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

Intracellular injections of EGTA block induction of hippocampal long-term potentiation

1983 • 1,106 citations

Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits

1991 • 1,076 citations

Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells

1982 • 940 citations

Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum

1991 • 875 citations

A G Protein Couples Serotonin and GABA _B Receptors to the Same Channels in Hippocampus

1986 • 870 citations

Postsynaptic Calcium Is Sufficient for Potentiation of Hippocampal Synaptic Transmission

1988 • 830 citations

The role of divalent cations in the N‐methyl‐D‐aspartate responses of mouse central neurones in culture.

1988 • 810 citations

Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure

1989 • 745 citations

Identification of a Specialized Adenylyl Cyclase That May Mediate Odorant Detection

1990 • 695 citations

Glutamate activates multiple single channel conductances in hippocampal neurons

1987 • 691 citations

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

1992 • 623 citations

Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials

1987 • 585 citations

Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus

1982 • 583 citations

Calcium-dependent current generating the afterhyperpolarization of hippocampal neurons

1986 • 560 citations

Hebbian synapses in hippocampus.

1986 • 560 citations

The Drosophila learning and memory gene rutabaga encodes a - adenylyl cyclase

1992 • 513 citations

Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP

1988 • 512 citations

A persistent postsynaptic modification mediates long-term potentiation in the hippocampus

1988 • 496 citations

Control by Asparagine Residues of Calcium Permeability and Magnesium Blockade in the NMDA Receptor

1992 • 437 citations

Molecular Neurobiology of Glutamate Receptors

1992 • 436 citations

Expression and characterization of calmodulin-activated (type I) adenylylcyclase

1991 • 435 citations

Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells

1983 • 413 citations

A long-term depression of AMPA currents in cultured cerebellar purkinje neurons

1991 • 405 citations

Adenylyl cyclases

1992 • 397 citations

Synaptic modification of parallel fibre‐Purkinje cell transmission in in vitro guinea‐pig cerebellar slices.

1987 • 377 citations

Cloning and expression of a widely distributed (type IV) adenylyl cyclase.

1991 • 363 citations

Participation of Postsynaptic PKC in Cerebellar Long-Term Depression in Culture

1991 • 340 citations

Postsynaptic hyperpolarization during conditioning reversibly blocks induction of long-term potentiation

1986 • 324 citations

Cyclic adenosine 3',5'‐monophosphate mediates beta‐receptor actions of noradrenaline in rat hippocampal pyramidal cells.

1986 • 308 citations

The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits

1988 • 306 citations

Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III

1987 • 288 citations

Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain.

1991 • 286 citations

Quisqualate receptors are specifically involved in cerebellar synaptic plasticity

1987 • 273 citations

Neurotransmitter action: Opening of ligand-gated ion channels

1993 • 267 citations

Identification by mutagenesis of a Mg2+ -block site of the NMDA receptor channel

1992 • 264 citations

Isolation and characterization of a novel cardiac adenylylcyclase cDNA.

1992 • 263 citations

Calcium is an intracellular mediator of the climbing fiber in induction of cerebellar long-term depression.

1990 • 254 citations

Quantal release of neurotransmitter and long-term potentiation

1993 • 237 citations

Ca2+ Entry via postsynaptic voltage-sensitive Ca2+ channels can transiently potentiate excitatory synaptic transmission in the hippocampus

1992 • 237 citations

Activation of protein kinase C induces a long-term depression of glutamate sensitivity of cerebellar Purkinje cells. An in vitro study

1988 • 234 citations

Phorbol esters block a voltage-sensitive chloride current in hippocampal pyramidal cells

1986 • 233 citations

Messengers mediating Jong-term desensitization in cerebellar Purkinje cells

1990 • 219 citations

Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family.

1992 • 201 citations

Quisqualate Metabotropic Receptors Modulate NMDA Currents and Facilitate Induction of Long‐Term Potentiation Through Protein Kinase C

1992 • 200 citations

Protein kinases, nitric oxide and long-term depression of synapses in the cerebellum

1990 • 182 citations

Two members of a widely expressed subfamily of hormone-stimulated adenylyl cyclases.

1992 • 175 citations

Biochemical studies of stimulus convergence during classical conditioning in Aplysia: dual regulation of adenylate cyclase by Ca2+/calmodulin and transmitter

1991 • 163 citations

Protein kinases and phosphatase inhibitors mediating long-term desensitization of glutamate receptors in cerebellar Purkinje cells

1992 • 133 citations

Temporal asymmetry in activation of Aplysia adenylyl cyclase by calcium and transmitter may explain temporal requirements of conditioning.

1992 • 131 citations

Regulation of cyclic adenosine 3',5'-monophosphate levels in guinea-pig cerebral cortex by interaction of alpha adrenergic and adenosine receptor activity.

1975 • 126 citations

Fluoronorepinephrines: specific agonists for the activation of alpha and beta adrenergic-sensitive cyclic AMP-generating systems in brain slices.

1980 • 125 citations

Enhancement of β-adrenergic responses by Gi-linked receptors in rat hippocampus

1993 • 122 citations

Characterization of the relationship between gamma-aminobutyric acid B agonists and transmitter-coupled cyclic nucleotide-generating systems in rat brain.

1985 • 113 citations

Differential pre‐ and postsynaptic mechanisms for synapic potentiation and depression between a granule cell and a purkinje cell in rat cerebellar culture

1991 • 102 citations

The cellular basis of cerebellar plasticity

1991 • 89 citations

Activation of glutamate metabotropic receptors induces long-term potentiation

1992 • 78 citations

The effects of trans-ACPD on long-term potentiation in the rat hippocampal slice

1991 • 40 citations

Differential blocking action of Joro spider toxin analog on parallel fiber and climbing fiber synapses in cerebellar Purkinje cells

1991 • 24 citations