The retardation of aging by caloric restriction: its significance in the transgenic era

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

1997 • 2,174 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1999 • 1,688 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

2003 • 1,328 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake

1986 • 968 citations

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

2001 • 814 citations

Redox Regulation of Forkhead Proteins Through a p66shc -Dependent Signaling Pathway

2002 • 810 citations

Adipose Tissue Selective Insulin Receptor Knockout Protects against Obesity and Obesity-Related Glucose Intolerance

2002 • 806 citations

Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

1996 • 787 citations

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)

1997 • 784 citations

Growth Curves and Survival Characteristics of the Animals Used in the Biomarkers of Aging Program

1999 • 658 citations

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice¹

2000 • 613 citations

Mechanisms of aging: an appraisal of the oxidative stress hypothesis1,2 1This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Rajindar S. Sohal

2002 • 588 citations

Molecular basis of the little mouse phenotype and Implications for cell type-specific growth

1993 • 477 citations

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

2002 • 431 citations

Extending the lifespan of long-lived mice

2001 • 425 citations

DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE

1929 • 324 citations

Delayed Occurrence of Fatal Neoplastic Diseases in Ames Dwarf Mice: Correlation to Extended Longevity

2003 • 297 citations

Insulin Receptor Knockout Mice

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Inherited Ateliotic Dwarfism in Mice: Characteristics of the mutation, little, on Chromosome 6

1976 • 241 citations

The Snell dwarf mutation Pit1dw can increase life span in mice

2002 • 213 citations

Effects of Overexpression of Copper-Zinc and Manganese Superoxide Dismutases, Catalase, and Thioredoxin Reductase Genes on Longevity in Drosophila melanogaster

2003 • 186 citations

Assessment of Growth Parameters and Life Span of GHR/BP Gene-Disrupted Mice

2000 • 183 citations

Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice

2002 • 179 citations

Reduced Levels of Thyroid Hormones, Insulin, and Glucose, and Lower Body Core Temperature in the Growth Hormone Receptor/Binding Protein Knockout Mouse

2001 • 167 citations

A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan

2002 • 166 citations

Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4

1993 • 163 citations

Evidence That Ames Dwarf Mice Age Differently from Their Normal Siblings in Behavioral and Learning and Memory Parameters

2001 • 152 citations

Transgenic Mice Overexpressing Urokinase-Type Plasminogen Activator in the Brain Exhibit Reduced Food Consumption, Body Weight and Size, and Increased Longevity

1997 • 122 citations

Does overexpression of Cu,Zn-SOD extend life span in Drosophila melanogaster?

2003 • 120 citations

Life Span Extension by Reduction in Growth Hormone-Insulin-Like Growth Factor-1 Axis in a Transgenic Rat Model

2002 • 111 citations

Effects of growth hormone on hypothalamic catalase and Cu/Zn superoxide dismutase1

2000 • 109 citations

STIMULATION OF GROWTH IN THE LITTLE MOUSE

1976 • 107 citations

Low Body Temperature in Long-Lived Ames Dwarf Mice at Rest and During Stress

1999 • 106 citations

Experimental IGF-I Receptor Deficiency Generates a Sexually Dimorphic Pattern of Organ-Specific Growth Deficits in Mice, Affecting Fat Tissue in Particular

2001 • 98 citations

New mouse dw allele: Genetic location and effects on lifespan and growth hormone levels

1980 • 87 citations

Prolonging the Life Span

1934 • 74 citations

Models of Growth Hormone and IGF-1 Deficiency: Applications to Studies of Aging Processes and Life-Span Determination

2002 • 71 citations

The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility

2001 • 44 citations

Experimental IGF-I Receptor Deficiency Generates a Sexually Dimorphic Pattern of Organ-Specific Growth Deficits in Mice, Affecting Fat Tissue in Particular

2001 • 27 citations