A Positive Regulatory Role for Suppressor of Cytokine Signaling 1 in IFN-γ-Induced MHC Class II Expression in Fibroblasts

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

1998 • 951 citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

1998 • 940 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 ^WAF1/CIP1 Mediated by STAT1

1996 • 796 citations

Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase

1999 • 771 citations

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

1999 • 767 citations

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

1999 • 712 citations

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

1998 • 596 citations

The target of rapamycin (TOR) proteins

2001 • 595 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

1996 • 529 citations

The Bare Lymphocyte Syndrome and the Regulation of MHC Expression

2001 • 516 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

SOCS: physiological suppressors of cytokine signaling

2000 • 457 citations

Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1

1998 • 433 citations

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

1999 • 428 citations

The Suppressor of Cytokine Signaling (SOCS) 1 and SOCS3 but Not SOCS2 Proteins Inhibit Interferon-mediated Antiviral and Antiproliferative Activities

1998 • 404 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1999 • 377 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

Activation of the MHC Class II Transactivator CIITA by Interferon-γ Requires Cooperative Interaction between Stat1 and USF-1

1998 • 358 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2

2001 • 304 citations

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice

1998 • 290 citations

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

1998 • 246 citations

Stat1-independent regulation of gene expression in response to IFN-γ

2001 • 243 citations

Roles of Phosphatidylinositol 3-Kinase in Interferon-γ-dependent Phosphorylation of STAT1 on Serine 727 and Activation of Gene Expression

2001 • 241 citations

Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression

2000 • 211 citations

Socs1 binds to multiple signalling proteins and suppresses Steel factor-dependent proliferation

1999 • 205 citations

Chlamydia Inhibits Interferon γ–inducible Major Histocompatibility Complex Class II Expression by Degradation of Upstream Stimulatory Factor 1

1999 • 200 citations

Degradation of Transcription Factor Rfx5 during the Inhibition of Both Constitutive and Interferon γ–Inducible Major Histocompatibility Complex Class I Expression in Chlamydia-Infected Cells

2000 • 199 citations

Regulation of transcription of MHC class II genes

1997 • 199 citations

Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome

2001 • 194 citations

Interferon γ Induces the Expression of p21waf-1 and Arrests Macrophage Cell Cycle, Preventing Induction of Apoptosis

1999 • 183 citations

Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation

2001 • 175 citations

A Janus Kinase Inhibitor, JAB, Is an Interferon-γ–Inducible Gene and Confers Resistance to Interferons

1998 • 172 citations

Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation

2000 • 168 citations

The Interferon-Inducible p202 Protein as a Modulator of Transcription: Inhibition of NF-κB, c-Fos, and c-Jun Activities

1996 • 152 citations

The tumor suppressor activity of SOCS-1

2002 • 133 citations

Different protein turnover of interleukin‐6‐type cytokine signalling components

1999 • 123 citations

Inhibition of E2F-mediated transcription by p202.

1996 • 109 citations

The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1)

1992 • 108 citations

IFN-γ Regulation of Class II Transactivator Promoter IV in Macrophages and Microglia: Involvement of the Suppressors of Cytokine Signaling-1 Protein

2001 • 104 citations

Escape of Human Cytomegalovirus from HLA-DR-Restricted CD4⁺T-Cell Response Is Mediated by Repression of Gamma Interferon-Induced Class II Transactivator Expression

1999 • 78 citations

Mechanisms of interferon-induced cell cycle arrest

2000 • 74 citations

Gamma-interferon induces an irreversible growth arrest in mid-G1 in mammary epithelial cells which correlates with a block in hyperphosphorylation of retinoblastoma.

1996 • 62 citations

Repression of I-Aβ Gene Expression by the Transcription Factor PU.1

1995 • 39 citations

The Expression of MHC Class II Genes in Macrophages Is Cell Cycle Dependent

2000 • 37 citations

Translational control of MHC class II I-A molecules by IFN-gamma.

1998 • 37 citations

From transcription to cell surface expression, the induction of MHC class II I-Aα by interferon-γ in macrophages is regulated at different levels

2001 • 32 citations

The Janus Kinase Inhibitor, JAB/SOCS-1, Is an Interferon-γ Inducible Gene and Determines the Sensitivity to Interferons

2000 • 31 citations

Translational Control of MHC Class II I-A Molecules by IFN-γ

1998 • 29 citations

pRB is required for interferon-γ-induction of the MHC class II Aβ gene

1999 • 26 citations

Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression

2000 • 25 citations

The molecular basis of MHC class II deficiency and transcriptional control of MHC class II gene expression

1999 • 23 citations