Escape of Human Cytomegalovirus from HLA-DR-Restricted CD4⁺T-Cell Response Is Mediated by Repression of Gamma Interferon-Induced Class II Transactivator Expression

STATs and Gene Regulation

1997 • 3,927 citations

Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes.

1989 • 2,118 citations

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

1995 • 1,828 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1996 • 1,101 citations

The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol

1996 • 1,083 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Cytotoxic T Cells in Cytomegalovirus Infection

1982 • 610 citations

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA

1997 • 510 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

The ER-Luminal Domain of the HCMV Glycoprotein US6 Inhibits Peptide Translocation by TAP

1997 • 472 citations

Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains.

1996 • 412 citations

Human cytomegalovirus inhibits antigen presentation by a sequential multistep process.

1996 • 379 citations

Activation of the MHC Class II Transactivator CIITA by Interferon-γ Requires Cooperative Interaction between Stat1 and USF-1

1998 • 358 citations

Human Cytomegalovirus Inhibits Major Histocompatibility Complex Class II Expression By Disruption of the Jak/Stat Pathway

1998 • 337 citations

Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.

1994 • 318 citations

A Viral ER-Resident Glycoprotein Inactivates the MHC-Encoded Peptide Transporter

1997 • 314 citations

Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains

1995 • 278 citations

The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation

1997 • 274 citations

Formation of STAT1-STAT2 Heterodimers and Their Role in the Activation of IRF-1 Gene Transcription by Interferon-α

1996 • 196 citations

TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.

1997 • 177 citations

MHC class II restricted antigen presentation

1997 • 165 citations

IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo.

1997 • 162 citations

Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains

1997 • 161 citations

Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines.

1997 • 160 citations

Interferon Regulatory Factor 1 Is Required for Mouse Gbp Gene Activation by Gamma Interferon

1995 • 140 citations

TGF-beta attenuates the class II transactivator and reveals an accessory pathway of IFN-gamma action.

1997 • 127 citations

Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes.

1996 • 125 citations

Interferon (IFN) beta acts downstream of IFN-gamma-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-gamma.

1995 • 115 citations

Anti-human cytomegalovirus activity of cytokines produced by CD4+ T-cell clones specifically activated by IE1 peptides in vitro

1996 • 107 citations

Cytomegaloviruses use multiple mechanisms to elude the host immune response

1997 • 102 citations

Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells.

1994 • 89 citations

Comparative analysis of fourteen individual human cytomegalovirus proteins for helper T cell response

1995 • 87 citations

Murine Cytomegalovirus Inhibits Interferon γ–induced Antigen Presentation to CD4 T Cells by Macrophages Via Regulation of Expression of Major Histocompatibility Complex Class II–associated Genes

1998 • 86 citations

Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells

1995 • 83 citations

Human MHC class II molecules as differentiation markers

1982 • 68 citations

Fine specificity of cellular immune responses in humans to human cytomegalovirus immediate-early 1 protein

1991 • 64 citations

Presentation of a cytosolic antigen by major histocompatibility complex class II molecules requires a long-lived form of the antigen

1996 • 51 citations

A 64,000 dalton matrix protein of human cytomegalovirus induces in vitro immune responses similar to those of whole viral antigen.

1985 • 48 citations

Analysis of the Proliferative T Cell Response to Human Cytomegalovirus Major Immediate‐Early Protein (IEl): Phenotype, Frequeney and Variability*

1995 • 43 citations

The N-terminal 513 amino acids of the envelope glycoprotein gB of human cytomegalovirus stimulates both B- and T-cell immune responses in humans

1991 • 36 citations

Presentation of newly synthesized glycoproteins to CD4+ T lymphocytes. An analysis using influenza hemagglutinin transport mutants.

1993 • 25 citations