Activation of the MHC Class II Transactivator CIITA by Interferon-γ Requires Cooperative Interaction between Stat1 and USF-1

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

STATs and Gene Regulation

1997 • 3,927 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

1995 • 1,826 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

1994 • 854 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

1993 • 711 citations

The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.

1990 • 584 citations

Sequences and Factors: A Guide to MHC Class-II Transcription

1992 • 540 citations

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA

1997 • 510 citations

Cooperative interaction of an initiator-binding transcription initiation factor and the helix–loop–helix activator USF

1991 • 505 citations

REGULATION OF MHC CLASS II GENES: Lessons from a Disease

1996 • 488 citations

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

1996 • 486 citations

TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif.

1990 • 484 citations

Synergy between Interferon-γ and Tumor Necrosis Factor-α in Transcriptional Activation Is Mediated by Cooperation between Signal Transducer and Activator of Transcription 1 and Nuclear Factor κB

1997 • 410 citations

Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor.

1991 • 378 citations

A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).

1995 • 334 citations

Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells

1994 • 328 citations

Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes.

1994 • 318 citations

Involvement of the IRF-1 Transcription Factor in Antiviral Responses to Interferons

1994 • 306 citations

Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process

1995 • 303 citations

In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence

1994 • 290 citations

Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X

1988 • 275 citations

Stat1 Depends on Transcriptional Synergy with Sp1

1995 • 272 citations

A helix-loop-helix protein related to the immunoglobulin E box-binding proteins.

1990 • 244 citations

RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency

1997 • 223 citations

Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y.

1994 • 176 citations

IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo.

1997 • 162 citations

Human MHC class II gene transcription directed by the car☐yl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency

1995 • 156 citations

Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.

1994 • 155 citations

Interferon Regulatory Factor 1 Is Required for Mouse Gbp Gene Activation by Gamma Interferon

1995 • 140 citations

Combined immunodeficiency with defective expression in MHC class II genes.

1989 • 131 citations

Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes.

1996 • 125 citations

The helix-loop-helix containing transcription factor USF binds to and transactivates the promoter of the p53 tumor suppressor gene

1993 • 119 citations

Quantitative control of MHC class II expression by the transactivator CIITA

1998 • 117 citations

Transforming Growth Factor βl-Responsive Element: Closely Associated Binding Sites for USF and CCAAT-Binding Transcription Factor-Nuclear Factor I in the Type 1 Plasminogen Activator Inhibitor Gene

1992 • 112 citations

Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promoters.

1994 • 97 citations

Max and c-Myc/Max DNA-binding activities in cell extracts.

1992 • 94 citations

Recombinant 43-kDa USF binds to DNA and activates transcription in a manner indistinguishable from that of natural 43/44-kDa USF.

1991 • 88 citations

Multiple elements in human β-globin locus control region 5′ HS 2 are involved in enhancer activity and position independent, transgene expression

1994 • 87 citations

Induction by interleukin-6 of interferon regulatory factor 1 (IRF-1) gene expression through the palindromic interferon response element pIRE and cell type-dependent control of IRF-1 binding to DNA.

1994 • 76 citations

MHC Class II‐Deficient Combined Immunodeficiency: A Disease of Gene Regulation

1994 • 68 citations

Two DNA-binding proteins discriminate between the promoters of different members of the major histocompatibility complex class II multigene family.

1990 • 66 citations

Transforming growth factor beta 1-responsive element: closely associated binding sites for USF and CCAAT-binding transcription factor-nuclear factor I in the type 1 plasminogen activator inhibitor gene.

1992 • 64 citations

The human growth hormone gene contains both positive and negative control elements.

1988 • 60 citations

Identification of USF as the ubiquitous murine factor that binds to and stimulates transcription from the immunoglobulin λ2 chain promoter

1992 • 24 citations

A PCR-based assay for reporter gene expression.

1992 • 20 citations