Gamma-interferon induces an irreversible growth arrest in mid-G1 in mammary epithelial cells which correlates with a block in hyperphosphorylation of retinoblastoma.

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

The interferons. Mechanisms of action and clinical applications

1991 • 580 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1994 • 493 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.

1995 • 336 citations

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1991 • 326 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

The cell cycle and the retinoblastoma protein family

1994 • 309 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

Structure and cell cycle-regulated transcription of the human cyclin A gene.

1994 • 272 citations

Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter

1995 • 250 citations

Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.

1994 • 242 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

The Petinoblastoma Tumor Suppressor Protein

1994 • 215 citations

The Transcription Factor E2F-1 Is a Downstream Target of RB Action

1995 • 190 citations

Interferon alfa and gamma inhibit proliferation and collagen synthesis of human ito cells in culture

1995 • 181 citations

Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins

1995 • 179 citations

DP and E2F proteins: components of a heterodimeric transcription factor implicated in cell cycle control

1994 • 152 citations

Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon gamma. Antagonism by retinoic acid and transforming growth factor beta 1.

1994 • 151 citations

Transcriptional control by E2F

1995 • 147 citations

The transcription factor E2F-1 mediates the autoregulation of RB gene expression

1994 • 122 citations

Effect of Tumor Suppressors on Cell Cycle-Regulatory Genes: RB Suppresses p34cdc2 Expression and Normal p53 Suppresses Cyclin A Expression

1994 • 102 citations

E2F-dependent regulation of human MYC: trans-activation by cyclins D1 and A overrides tumour suppressor protein functions.

1994 • 102 citations

Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth.

1995 • 89 citations

Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells.

1993 • 68 citations

Interferon gamma selectively inhibits very primitive CD342+CD38- and not more mature CD34+CD38+ human hematopoietic progenitor cells.

1994 • 67 citations

Biochemical events accompanying macrophage activation and the inhibition of colony‐stimulating factor‐1‐induced macrophage proliferation by tumor necrosis factor‐α, interferon‐γ, and lipopolysaccharide

1992 • 63 citations

Control of squamous differentiation in tracheobronchial and epidermal epithelial cells: role of retinoids.

1992 • 63 citations

pRB, p107 and the regulation of the E2F transcription factor

1994 • 61 citations

Intraperitoneal chemotherapy in the management of ovarian cancer

1993 • 54 citations

Down-regulation of the c-myc proto-oncogene in inhibition of vascular smooth-muscle cell proliferation: a signal for growth arrest?

1994 • 51 citations

Inhibition of growth of normal and human papillomavirus-transformed keratinocytes in monolayer and organotypic cultures by interferon-gamma and tumor necrosis factor-alpha.

1995 • 45 citations

Differential responsiveness of human bronchial epithelial cells, lung carcinoma cells, and bronchial fibroblasts to interferon-gamma in vitro.

1994 • 40 citations

Therapeutic effects of monoclonal antibody g250, interferons and tumor necrosis factor, in mice with renal‐cell carcinoma xenografts

1994 • 37 citations

The G₁/S Boundary-Specific Enhancer of the Rat cdc2 Promoter

1995 • 34 citations

Promoter-dependent Photocross-linking of the Acidic Transcriptional Activator E2F-1 to the TATA-binding Protein

1995 • 30 citations

Recombinant interferon‐γ inhibits the in vitro proliferation of human myeloma cells

1994 • 29 citations

Deregulated c-myc expression overrides IFN gamma-induced macrophage growth arrest.

1995 • 22 citations

Downmodulation of c-myc expression by interferon γ and tumour necrosis factor α precedes growth arrest in human melanoma cells

1992 • 17 citations

Interferon-α, interferon-γ and sizofiran in the adjuvant therapy in ovarian cancer — a preliminary trial

1992 • 14 citations

Analysis of MTS1/CDK4 in female breast carcinomas

1995 • 13 citations

Positive interactions between human interferon and cepharanthin against human cancer cells in vitro and in vivo

1994 • 12 citations

Antitumor activity of TNF-alpha, IL-1, and IFN-gamma against three human osteosarcoma cell lines.

1991 • 12 citations

Disseminated melanoma, preclinical therapeutic studies, clinical trials, and patient treatment

1993 • 8 citations

Growth Inhibition of Human Endothelial Cells by Human Recombinant Tumor Necrosis Factor Alpha and Interferon-Gamma

1994 • 6 citations