Mechanisms of interferon-induced cell cycle arrest

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cancer Cell Cycles

1996 • 5,379 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Principles of CDK regulation

1995 • 3,267 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1998 • 1,584 citations

A Restriction Point for Control of Normal Animal Cell Proliferation

1974 • 1,389 citations

Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).

1995 • 1,117 citations

Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1

1999 • 1,028 citations

Cyclin E-CDK2 is a regulator of p27Kip1.

1997 • 915 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21 ^WAF1/CIP1 Mediated by STAT1

1996 • 796 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Cdc25 cell-cycle phosphatase as a target of c-myc

1996 • 691 citations

Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma.

1996 • 529 citations

Biology of the Interleukin-2 Receptor

1998 • 489 citations

The growing family of interferon regulatory factors

1997 • 480 citations

Interferons and other regulatory cytokines

1988 • 429 citations

Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

1997 • 411 citations

Close link between reduction of c-myc expression by interferon and G0/G1 arrest

1985 • 358 citations

Ras target proteins in eukaryotic cells

1995 • 316 citations

The Jak-Stat pathway in normal and perturbed hematopoiesis

2000 • 302 citations

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.

1994 • 289 citations

A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.

1993 • 273 citations

Retinoblastoma protein family in cell cycle and cancer: A review

1996 • 198 citations

Interferon γ Induces the Expression of p21waf-1 and Arrests Macrophage Cell Cycle, Preventing Induction of Apoptosis

1999 • 183 citations

Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

1994 • 150 citations

Molecular mechanisms underlying interferon-α-induced G0/G1 arrest: CKI-mediated regulation of G1 Cdk-complexes and activation of pocket proteins

1999 • 143 citations

Alpha Interferon Suppresses the Cyclin D3 and cdc25A Genes, Leading to a Reversible G₀-Like Arrest

1996 • 124 citations

Induction of Cip/Kip and Ink4 cyclin dependent kinase inhibitors by interferon-α in hematopoietic cell lines

1997 • 116 citations

Interferon-induces expression of cyclin-dependent kinase-inhibitors p21WAF1 and p27Kip1 that prevent activation of cyclin-dependent kinase by CDK-activating kinase (CAK)

1998 • 114 citations

IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.

1995 • 109 citations

Tumor Necrosis Factor Reduces c- myc Expression and Cooperates with Interferon-γ in HeLa Cells

1986 • 109 citations

Cell cycle targets of the DNA tumor viruses

1994 • 101 citations

Inhibitory effects of interferon on the expression of genes regulated by platelet-derived growth factor.

1985 • 97 citations

Perturbation of cell cycle regulators in human cancer.

1996 • 96 citations

IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells

1997 • 95 citations

Inactivation of a Cdk2 Inhibitor during Interleukin 2-Induced Proliferation of Human T Lymphocytes

1994 • 94 citations

Interferon alpha induces the expression of retinoblastoma gene product in human Burkitt lymphoma Daudi cells: role in growth regulation.

1992 • 92 citations

Cytokine triggered molecular pathways that control cell cycle arrest

1992 • 89 citations

Distinct mechanisms control the accumulation of the Rb-related p107 and p130 proteins during cell growth.

1998 • 87 citations

Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice.

1991 • 86 citations

The role of p27Kip1 in gamma interferon-mediated growth arrest of mammary epithelial cells and related defects in mammary carcinoma cells

1997 • 86 citations

Block of a glioma cell line in S by interferon

1981 • 79 citations

Double-stranded RNA-dependent Protein Kinase Mediates c-Myc Suppression Induced by Type I Interferons

1996 • 71 citations

Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line

1998 • 65 citations

Interferon-induced cell cycle changes in human hematopoietic cell lines and fresh leukemic cells.

1984 • 64 citations

Correlation between in vitro and in vivo sensitivity to human leucocyte interferon in patients with multiple myeloma

1985 • 61 citations

Interferon and Malignant Disease - How Does it Work and Why Doesn't it Always?

1998 • 61 citations

Interferon-α-induced G1 phase arrest through up-regulated expression of CDK inhibitors, p19Ink4D and p21Cip1 in mouse macrophages

1998 • 56 citations

p130, p107, and pRb Are Differentially Regulated in Proliferating Cells and during Cell Cycle Arrest by α-Interferon

1998 • 52 citations

Interferon-alpha inhibits proliferation in human T lymphocytes by abrogation of interleukin 2-induced changes in cell cycle-regulatory proteins.

1999 • 52 citations

Interferon treatment of human malignancies - a short review

1993 • 50 citations

Transcriptional repression of the E2F-1 gene by interferon-α is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes

1999 • 42 citations

Retardation of cell proliferation after expression of p202 accompanies an increase in p21(WAF1/CIP1).

1999 • 35 citations

Isolation and characterization of an interferon-resistant cell line deficient in the induction of (2'-5')oligoadenylate synthetase activity.

1983 • 26 citations

The involvement of protein kinase C in mediating growth suppressive signals of interferons in hematopoietic cells.

1991 • 23 citations

Interferon system defects in malignant T-cells.

1994 • 22 citations

Retinoblastoma protein family in cell cycle and cancer: A review

1996 • 20 citations

Interferon-γ impairs physiologic downregulation of cyclin-dependent kinase inhibitor, p27Kip1, during G1 phase progression in macrophages

1999 • 15 citations

Apoptosis and remodelling of beta cells by paracrine interferon-γ without insulitis in transgenic mice

1999 • 11 citations

Isolation and Characterization of an Interferon-Resistant Cell Line Deficient in the Induction of (2′-5′)Oligoadenylate Synthetase Activity

1983 • 9 citations

Influence of interferon-alpha on the expression of cellular oncogenes in primary chronic lymphocytic leukemia cells.

1988 • 7 citations