Inhibition of E2F-mediated transcription by p202.

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

1996 • 765 citations

Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1

1996 • 704 citations

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

Identification of a New Family of Tissue-Specific Basic Helix-Loop-Helix Proteins with a Two-Hybrid System

1995 • 655 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

The interferon system. A bird's eye view of its biochemistry.

1992 • 633 citations

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

1992 • 587 citations

Identification of a cellular transcription factor involved in E1A trans-activation

1986 • 551 citations

Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.

1993 • 498 citations

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

1994 • 493 citations

Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

1994 • 493 citations

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1995 • 459 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

The retinoblastoma protein binds to a family of E2F transcription factors.

1993 • 436 citations

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1991 • 435 citations

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1991 • 420 citations

Cell cycle regulation of the human cdc2 gene.

1992 • 396 citations

Differential regulation of E2F transactivation by cyclin/cdk2 complexes.

1994 • 393 citations

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation

1990 • 358 citations

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

1993 • 353 citations

Cell cycle-specific association of E2F with the p130 E1A-binding protein.

1993 • 348 citations

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.

1992 • 331 citations

E2F-4, a new member of the E2F transcription factor family, interacts with p107.

1994 • 331 citations

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.

1994 • 329 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo

1989 • 292 citations

Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

1994 • 283 citations

Binding to DNA and the Retinoblastoma Gene Product Promoted by Complex Formation of Different E2F Family Members

1993 • 271 citations

Functional synergy between DP-1 and E2F-1 in the cell cycle-regulating transcription factor DRTF1/E2F.

1993 • 267 citations

Nuclear factor E2F mediates basic transcription and trans-activation by E1a of the human MYC promoter.

1989 • 262 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.

1992 • 250 citations

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.

1995 • 248 citations

E2F and Cell Proliferation: A World Turned Upside Down

1996 • 234 citations

Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.

1994 • 214 citations

Multiple members of the E2F transcription factor family are the products of oncogenes.

1995 • 197 citations

Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.

1993 • 196 citations

The Interferon-Inducible p202 Protein as a Modulator of Transcription: Inhibition of NF-κB, c-Fos, and c-Jun Activities

1996 • 152 citations

Transcriptional control by E2F

1995 • 147 citations

The Retinoblastoma Protein Binds to a Family of E2F Transcription Factors

1993 • 135 citations

Interferons as Gene Activators

1989 • 124 citations

Binding of an Interferon-inducible Protein (p202) to the Retinoblastoma Protein

1995 • 110 citations

Single amino acid changes that render human IFN-alpha 2 biologically active on mouse cells.

1987 • 98 citations

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.

1995 • 96 citations

Interferon action: nucleolar and nucleoplasmic localization of the interferon-inducible 72-kD protein that is encoded by the Ifi 204 gene from the gene 200 cluster.

1992 • 86 citations

Molecular Cloning of Cellular Genes Encoding Retinoblastoma-Associated Proteins: Identification of a Gene with Properties of the Transcription Factor E2F

1992 • 82 citations

Interferon Action: Cytoplasmic and Nuclear Localization of the Interferon-Inducible 52-kD Protein That Is Encoded by the Ifi 202 Gene from the Gene 200 Cluster

1993 • 81 citations

Cyclin A/CDK2 Binds Directly to E2F-1 and Inhibits the DNA-Binding Activity of E2F-1/DP-1 by Phosphorylation

1994 • 81 citations

Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells.

1993 • 68 citations

The interferon-activatable gene 200 cluster: from structure toward function

1995 • 67 citations

A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the cell cycle transcription factor DRTF1/E2F.

1995 • 58 citations

Proto-oncogenic properties of the DP family of proteins.

1995 • 55 citations

The Rb-Related p107 Protein Can Suppress E2F Function Independently of Binding to Cyclin A/cdk2

1995 • 54 citations

The N-terminal Region of E2F-1 Is Required for Transcriptional Activation of a New Class of Target Promoter

1996 • 35 citations

Detailed analysis of the basic domain of the E2F1 transcription factor indicates that it is unique among bHLH proteins.

1994 • 35 citations

Cloning and characterization of E2F-2, a Novel Protein with the Biochemical Properties of Transcription Factor E2F

1993 • 30 citations

Constitutive expression of the interferon-inducible protein p202 in NIH 3T3 cells affects cell cycle progression.

1995 • 29 citations

Interferons and Interleukin-6 Suppress the DNA-Binding Activity of E2F in Growth-Sensitive Hematopoietic Cells

1993 • 21 citations

The Interferon-Inducible Growth-Inhibitory p202 Protein: DNA Binding Properties and Identification of a DNA Binding Domain

1996 • 20 citations

Two different protein-protein interactions in oligomeric complexes of SV40 large T antigen with the cellular oncoprotein p53.

1989 • 10 citations