Insulators: many functions, many mechanisms

Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

2001 • 2,768 citations

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

2001 • 2,746 citations

Regulation of chromatin structure by site-specific histone H3 methyltransferases

2000 • 2,709 citations

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

2000 • 1,706 citations

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

2001 • 1,685 citations

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

2000 • 1,493 citations

The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators

1999 • 1,076 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Detection in situ of genomic regulatory elements in Drosophila.

1987 • 773 citations

Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries

2001 • 746 citations

Promoter-specific binding of Rap1 revealed by genome-wide maps of protein–DNA association

2001 • 707 citations

ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor

1994 • 662 citations

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2

1998 • 641 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

A nuclear DNA attachment element mediates elevated and position-independent gene activity

1989 • 597 citations

Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus

2001 • 582 citations

A Novel Histone Acetyltransferase Is an Integral Subunit of Elongating RNA Polymerase II Holoenzyme

1999 • 453 citations

Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive

2000 • 439 citations

Highly Specific Antibodies Determine Histone Acetylation Site Usage in Yeast Heterochromatin and Euchromatin

2001 • 436 citations

DNA position-specific repression of transcription by a Drosophila zinc finger protein.

1992 • 418 citations

The Trithorax-like gene encodes the Drosophila GAGA factor

1994 • 409 citations

MATING-TYPE GENE SWITCHING IN SACCHAROMYCES CEREVISIAE

1998 • 405 citations

Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

1998 • 403 citations

The BTB/POZ domain: a new protein-protein interaction motif common to DNA- and actin-binding proteins.

1995 • 393 citations

Insulators and Boundaries: Versatile Regulatory Elements in the Eukaryotic Genome

2001 • 386 citations

A group of scs elements function as domain boundaries in an enhancer-blocking assay.

1992 • 383 citations

The boundaries of the silenced HMR domain in Saccharomyces cerevisiae

1999 • 370 citations

Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci

2001 • 362 citations

Intergenic Transcription and Developmental Remodeling of Chromatin Subdomains in the Human β-globin Locus

2000 • 344 citations

All in the Family: the BTB/POZ, KRAB, and SCAN Domains

2001 • 338 citations

A Chromatin Insulator Determines the Nuclear Localization of DNA

2000 • 337 citations

Intergenic transcription and transinduction of the human β-globin locus

1997 • 334 citations

Visualization of chromosomal domains with boundary element-associated factor BEAF-32

1995 • 321 citations

CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus

2001 • 318 citations

Interactions of the LIM-domain-binding factor Ldbl with LIM homeodomain proteins

1996 • 314 citations

Experimental observations of a nuclear matrix

2001 • 311 citations

Crystal structure of the BTB domain from PLZF

1998 • 301 citations

Limitations of silencing at native yeast telomeres

1999 • 297 citations

A drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation

1995 • 296 citations

Half a Century of “The Nuclear Matrix”

2000 • 295 citations

Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice.

1990 • 289 citations

Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice.

1992 • 288 citations

Yeast Heterochromatin: Regulation of Its Assembly and Inheritance by Histones

1998 • 286 citations

The su(Hw) protein insulates expression of the Drosophila melanogaster white gene from chromosomal position-effects.

1993 • 280 citations

The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain.

1988 • 280 citations

RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae

2001 • 280 citations

The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes.

1990 • 276 citations

Enhancer–promoter specificity mediated by DPE or TATA core promoter motifs

2001 • 262 citations

The 87A7 chromomere

1985 • 249 citations

A chromatin insulator protects retrovirus vectors from chromosomal position effects

2000 • 243 citations

Cohabitation of insulators and silencing elements in yeast subtelomeric regions

1999 • 239 citations

Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex.

1996 • 237 citations

Ligand-inducible and liver-specific target gene expression in transgenic mice

1997 • 234 citations

Core promoters: active contributors to combinatorial gene regulation: Figure 1.

2001 • 232 citations

Locus control regions: coming of age at a decade plus

1999 • 232 citations

Chromosomal Addresses of the Cohesin Component Mcd1p

2000 • 228 citations

The solution structure of a specific GAGA factor–DNA complex reveals a modular binding mode

1997 • 219 citations

The role of insulator elements in defining domains of gene expression

1997 • 217 citations

Polycomb and Trithorax Group Proteins Mediate the Function of a Chromatin Insulator

1998 • 213 citations

Loss of Insulator Activity by Paired Su(Hw) Chromatin Insulators

2001 • 209 citations

Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila

1997 • 208 citations

In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element

1990 • 202 citations

The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon.

1988 • 197 citations

The cHS4 Insulator Increases the Probability of Retroviral Expression at Random Chromosomal Integration Sites

2000 • 197 citations

Effects of cis Arrangement of Chromatin Insulators on Enhancer-Blocking Activity

2001 • 193 citations

Transcription of the hypersensitive site HS2 enhancer in erythroid cells.

1992 • 191 citations

The Fab-8 boundary defines the distal limit of the bithorax complex iab-7 domain and insulates iab-7 from initiation elements and a PRE in the adjacent iab-8 domain

2000 • 190 citations

The Drosophila su(Hw) gene, which controls the phenotypic effect of the gypsy transposable element, encodes a putative DNA-binding protein.

1988 • 184 citations

The Zw5 protein, a component of the scs chromatin domain boundary, is able to block enhancer-promoter interaction

1999 • 181 citations

Engineering of a Mouse for the in Vivo Profiling of Estrogen Receptor Activity

2001 • 176 citations

Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganizes promoter topology

1999 • 173 citations

Chromosome ends: all the same under their caps

1997 • 172 citations

Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function

2001 • 171 citations

Silencing of gene expression: implications for design of retrovirus vectors

2001 • 168 citations

The Fab-7 element of the bithorax complex attenuates enhancer-promoter interactions in the Drosophila embryo.

1996 • 166 citations

The Nuclear Matrix

1997 • 165 citations

A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast

2001 • 163 citations

A structural basis for variegating position effects

1984 • 160 citations

Enzymatic activities of Sir2 and chromatin silencing

2001 • 158 citations

The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex.

1993 • 154 citations

GAGA mediates the enhancer blocking activity of the eve promoter in the Drosophila embryo

1998 • 153 citations

An insulator element and condensed chromatin region separate the chicken β-globin locus from an independently regulated erythroid-specific folate receptor gene

1999 • 151 citations

Structural and functional conservation at the boundaries of the chicken β-globin domain

2000 • 149 citations

Putting Boundaries on Silence

1999 • 149 citations

Development of stable cell lines for production or regulated expression using matrix attachment regions

2001 • 144 citations

Insulation of Enhancer-Promoter Communication by a Gypsy Transposon Insert in the Drosophila cut Gene: Cooperation between Suppressor of Hairy-wing and Modifier of mdg4 Proteins

2001 • 134 citations

UASrpg can function as a heterochromatin boundary element in yeast

1999 • 132 citations

The fourth chromosome of Drosophila melanogaster : Interspersed euchromatic and heterochromatic domains

2000 • 131 citations

Chromatin domain boundaries in the Bithorax complex

1998 • 130 citations

Location of enhancers is essential for the imprinting of H19 and Igf2 genes

1998 • 126 citations

A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.

1993 • 124 citations

Gene activation by recruitment of the RNA polymerase II holoenzyme.

1996 • 123 citations

Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo

2000 • 117 citations

Characterization of the transvection mediating region of the Abdominal-B locus in Drosophila

1999 • 116 citations

Hypersensitive site 5 of the human beta locus control region functions as a chromatin insulator

1994 • 108 citations

An enhancer-blocking element between α and δ gene segments within the human T cell receptor α/δ locus

1997 • 103 citations

Molecular analysis of the zeste-white interaction reveals a promoter-proximal element essential for distant enhancer-promoter communication.

1992 • 96 citations

Human Matrix Attachment Regions Insulate Transgene Expression from Chromosomal Position Effects in Drosophila melanogaster

1998 • 96 citations

Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein.

1999 • 94 citations

CpG methylation regulates the Igf2/H19 insulator

2001 • 92 citations

Transvection in the Drosophila Abd-B Domain: Extensive Upstream Sequences Are Involved in Anchoring Distant cis-Regulatory Regions to the Promoter

1998 • 88 citations

Association of the 5'HS4 sequence of the chicken beta-globin locus control region with human EF1 alpha gene promoter induces ubiquitous and high expression of human CD55 and CD59 cDNAs in transgenic rabbits.

1999 • 85 citations

Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions

1999 • 85 citations

A comparison of invivo and invitro DNA-binding specificities suggests a new model for homeoprotein DNA binding in Drosophila embryos

1999 • 84 citations

An activation‐independent role of transcription factors in insulator function

2001 • 84 citations

Chip interacts with diverse homeodomain proteins and potentiates Bicoid activity in vivo

2000 • 84 citations

Dissection of the Ability of the Chicken Lysozyme Gene 5‘ Matrix Attachment Region To Stimulate Transgene Expression and To Dampen Position Effects^,

1996 • 82 citations

Transcriptional silencing in fission yeast

2000 • 82 citations

Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing

2000 • 80 citations

Chicken β-Globin 5′HS4 Insulators Function to Reduce Variability in Transgenic Founder Mice

2000 • 78 citations

Genes Regulating the Remote Wing Margin Enhancer in the Drosophila cut Locus

1996 • 78 citations

A specific promoter of the sensory cells of the inner ear defined by transgenesis

2001 • 67 citations

The yeastHMLI silencer defines a heterochromatin domain boundary by directional establishment of silencing

1999 • 66 citations

Chromosomal boundaries in S. cerevisiae

2001 • 66 citations

A 5′ β-globin matrix-attachment region and the polyoma enhancer together confer position-independent transcription

1994 • 62 citations

The 5‘ Boundary of the Human Apolipoprotein B Chromatin Domain in Intestinal Cells

2001 • 61 citations

The DNA-Binding and Enhancer-Blocking Domains of the Drosophila suppressor of Hairy-wing Protein

1996 • 60 citations

Turning telomeres off and on

2001 • 60 citations

A Fission Yeast Repression Element Cooperates With Centromere-like Sequences and Defines amatSilent Domain Boundary

2000 • 59 citations

Severe position effects imposed on a 1 kb mouse whey acidic protein gene promoter are overcome by heterologous matrix attachment regions

1996 • 55 citations

Engineering of a Mouse for the in Vivo Profiling of Estrogen Receptor Activity

2001 • 51 citations

Deletion of an Insulator Element by the Mutation facet-strawberry in Drosophila melanogaster

2000 • 49 citations

The suppressor of Hairy-wing protein regulates the tissue-specific expression of the Drosophila gypsy retrotransposon.

1995 • 45 citations

Distal upstream tyrosinase S/MAR-containing sequence has regulatory properties specific to subsets of melanocytes

1999 • 44 citations

INTRAGENIC DELETIONS AND SALIVARY BAND RELATIONSHIPS IN DROSOPHILA

1975 • 40 citations

Upstream element of the sea urchin arylsulfatase gene serves as an insulator.

1999 • 39 citations

The Repeat Organizer, a Specialized Insulator Element within the Intergenic Spacer of the Xenopus rRNA Genes

1997 • 37 citations

Preferential insertion of P elements into genes expressed in the germ-line ofDrosophila melanogaster

1990 • 37 citations

Enhancer blocking activity located near the 3′ end of the sea urchin early H2A histone gene

1997 • 36 citations

Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes.

1999 • 34 citations

Position-independent human β-globin gene expression mediated by a recombinant adeno-associated virus vector carrying the chicken β-globin insulator

1999 • 31 citations

The beta‐globin locus control region versus gene therapy vectors: a struggle for expression

2001 • 30 citations

Enhancer-Blocking Activity Within the DNase I Hypersensitive Site 2 to 6 Region Between the TCR α and Dad1 Genes

1999 • 29 citations

Two insulators are not better than one.

2001 • 29 citations

The Sea Urchin sns Insulator Blocks CMV Enhancer following Integration in Human Cells

2001 • 22 citations

Éléments isolateurs et protéines nucléaires à domaines BTB/POZ.

2001 • 1 citations