Transcription of the hypersensitive site HS2 enhancer in erythroid cells.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

NUCLEASE HYPERSENSITIVE SITES IN CHROMATIN

1988 • 1,233 citations

Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins

1989 • 996 citations

A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

1983 • 933 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.

1990 • 477 citations

Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

1987 • 440 citations

GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.

1987 • 395 citations

When polymerases collide: Replication and the transcriptional organization of the E. coli chromosome

1988 • 375 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

Developmental regulation of β-globin gene switching

1988 • 328 citations

Two tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase gene

1989 • 326 citations

Detailed analysis of the site 3 region of the human beta-globin dominant control region.

1990 • 320 citations

Multiple DNA-pRotein Interactions Governing High-Precision DNA Transactions

1986 • 302 citations

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

1990 • 301 citations

The SV40 72 bp repeat preferentially potentiates transcription starting from proximal natural or substitute promoter elements

1983 • 299 citations

Fos-Jun heterodimers and jun homodimers bend DNA in opposite orientations: Implications for transcription factor cooperativity

1991 • 296 citations

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.

1989 • 280 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

1983 • 266 citations

Rapid reprogramming of globin gene expression in transient heterokaryons

1986 • 246 citations

Gamma delta beta-thalassemia due to a de novo mutation deleting the 5' beta-globin gene activation-region hypersensitive sites.

1989 • 240 citations

A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene

1984 • 237 citations

Action at a Distance Along a DNA

1988 • 220 citations

An enhancer stimulates transcription in Trans when attached to the promoter via a protein bridge

1989 • 202 citations

A Bacterial Enhancer Functions to Tether a Transcriptional Activator Near a Promoter

1990 • 190 citations

Hb switching in chickens

1980 • 189 citations

A Transcriptional Enhancer Whose Function Imposes a Requirement That Proteins Track Along DNA

1992 • 130 citations

Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site.

1989 • 122 citations

Negative regulation of the human epsilon-globin gene by transcriptional interference: role of an Alu repetitive element.

1990 • 112 citations

A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia.

1985 • 106 citations

Synergistic enhancement of globin gene expression by activator protein-1-like proteins.

1990 • 105 citations

A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation

1990 • 79 citations

The use of psoralen-modified DNA to probe the mechanism of enhancer action

1986 • 56 citations

Yeast upstream activator protein GCN4 can stimulate transcription when its binding site replaces the TATA element.

1989 • 47 citations

Negative Regulation of the Human ε-Globin Gene by Transcriptional Interference: Role of an Alu Repetitive Element

1990 • 37 citations