CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus

Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member

1992 • 2,719 citations

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

2000 • 1,706 citations

Myotonic Dystrophy Mutation: an Unstable CTG Repeat in the 3′ Untranslated region of the Gene

1992 • 1,609 citations

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

2000 • 1,493 citations

An Unstable Triplet Repeat in a Gene Related to Myotonic Muscular Dystrophy

1992 • 1,437 citations

Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold

1984 • 1,088 citations

The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators

1999 • 1,076 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy

1992 • 721 citations

Myotonic Dystrophy in Transgenic Mice Expressing an Expanded CUG Repeat

2000 • 688 citations

Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues.

1995 • 576 citations

An Exceptionally Conserved Transcriptional Repressor, CTCF, Employs Different Combinations of Zinc Fingers To Bind Diverged Promoter Sequences of Avian and Mammalian c-myc Oncogenes

1996 • 536 citations

Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive

2000 • 439 citations

Insulators and Boundaries: Versatile Regulatory Elements in the Eukaryotic Genome

2001 • 386 citations

A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene.

1990 • 376 citations

Correlation between CTG trinucleotide repeat length and frequency of severe congenital myotonic dystrophy

1992 • 350 citations

Decreased Expression of Myotonin-Protein Kinase Messenger RNA and Protein in Adult Form of Myotonic Dystrophy

1993 • 302 citations

CTCF, a Conserved Nuclear Factor Required for Optimal Transcriptional Activity of the Chicken c-myc Gene, Is an 11-Zn-Finger Protein Differentially Expressed in Multiple Forms

1993 • 271 citations

Two domains of MyoD mediate transcriptional activation of genes in repressive chromatin: a mechanism for lineage determination in myogenesis.

1997 • 259 citations

Trinucleotide repeat expansion at the myotonic dystrophy locus reduces expression of DMAHP

1997 • 258 citations

Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy

2000 • 256 citations

Preferential Nucleosome Assembly at DNA Triplet Repeats from the Myotonic Dystrophy Gene

1994 • 235 citations

Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene

1997 • 216 citations

Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts

2000 • 208 citations

DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model

1999 • 200 citations

The complex pathology of trinucleotide repeats

1997 • 191 citations

The Zinc Finger Protein CTCF Binds to the APBβ Domain of the Amyloid β-Protein Precursor Promoter

1997 • 187 citations

A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)_n repeat

1995 • 181 citations

Effect of the myotonic dystrophy (DM) mutation on mRNA levels of the DM gene

1993 • 146 citations

A widely expressed transcription factor with multiple DNA sequence specificity,CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers

1998 • 142 citations

Structure and genomic sequence of the myotonic dystrophy (DM kinase) gene

1993 • 137 citations

Negative Protein 1, Which Is Required for Function of the Chicken Lysozyme Gene Silencer in Conjunction with Hormone Receptors, Is Identical to the Multivalent Zinc Finger Repressor CTCF

1997 • 133 citations

Effect of Myotonic Dystrophy Trinucleotide Repeat Expansion on DMPK Transcription and Processing

1995 • 133 citations

Expanded CTG triplet blocks from the myotonic dystrophy gene create the strongest known natural nucleosome positioning elements

1995 • 132 citations

Long CCG Triplet Repeat Blocks Exclude Nucleosomes: A Possible Mechanism for the Nature of Fragile Sites in Chromosomes

1996 • 122 citations

Nucleosome Assembly on CTG Triplet Repeats

1996 • 115 citations

The DMPK Gene of Severely Affected Myotonic Dystrophy Patients Is Hypermethylated Proximal to the Largely Expanded CTG Repeat

1998 • 105 citations

The 5′ flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer–promoter communication

2000 • 96 citations

Negative Transcriptional Regulation Mediated by Thyroid Hormone Response Element 144 Requires Binding of the Multivalent Factor CTCF to a Novel Target DNA Sequence

1999 • 72 citations

Transcriptional control: Imprinting insulation

2000 • 71 citations

Failure in detecting mRNA transcripts from the mutated allele in myotonic dystrophy muscle.

1993 • 53 citations

Sequence‐specific DNA‐binding proteins which interact with (G + C)‐rich sequences flanking the chicken c‐myc gene

1986 • 23 citations

Six transcripts map within 200 kilobases of the myotonic dystrophy expanded repeat

1998 • 11 citations

Gene regulation - Insulators and boundaries: Versatile regulatory elements in the eukaryotic genome

2001 • 8 citations