Severe position effects imposed on a 1 kb mouse whey acidic protein gene promoter are overcome by heterologous matrix attachment regions

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

A nuclear DNA attachment element mediates elevated and position-independent gene activity

1989 • 597 citations

A group of scs elements function as domain boundaries in an enhancer-blocking assay.

1992 • 383 citations

Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice.

1992 • 288 citations

The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice.

1994 • 259 citations

Dependence of Enhancer-Mediated Transcription of the Immunoglobulin μ Gene on Nuclear Matrix Attachment Regions

1994 • 216 citations

Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect.

1990 • 160 citations

Expression of a whey acidic protein transgene during mammary development. Evidence for different mechanisms of regulation during pregnancy and lactation.

1991 • 143 citations

Comparison of the Regulation of the Whey Acidic Protein Gene with that of a Hybrid Gene Containing the Whey Acidic Protein Gene Promoter in Transgenic Mice

1988 • 121 citations

Dynamic chromatin: The regulatory domain organization of eukaryotic gene loci

1991 • 116 citations

Dissection of the locus control function located on the chicken lysozyme gene domain in transgenic mice

1994 • 97 citations

A distal tyrosinase upstream element stimulates gene expression in neural-crest-derived melanocytes of transgenic mice: position-independent and mosaic expression

1994 • 68 citations

Breast cancer formation in transgenic animals induced by the whey acidic protein SV40 T antigen (WAP-SV-T) hybrid gene.

1993 • 57 citations

Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development.

1994 • 55 citations

High expression of the caprine β‐casein gene in transgenic mice

1992 • 55 citations

Distal regulatory elements required for rat whey acidic protein gene expression in transgenic mice.

1994 • 51 citations

Transgenic mice carrying the guinea-pig α-lactalbumin gene transcribe milk protein genes in their sebaceous glands during lactation

1991 • 36 citations

Expression of genomic and cDNA transgenes after co-integration in transgenic mice

1995 • 25 citations

Expanding the Potential of Restriction Endonucleases: Use of Hapaxoterministic Enzymes

1994 • 12 citations