Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators

1999 • 1,076 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

1996 • 779 citations

Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity

1998 • 654 citations

The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element

1983 • 467 citations

A regulatory system for use in gene transfer.

1994 • 434 citations

The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors

1997 • 409 citations

A group of scs elements function as domain boundaries in an enhancer-blocking assay.

1992 • 383 citations

Characterization of the chicken β-globin insulator

1997 • 381 citations

Regulation of metallothionein genes by heavy metalsappears to be mediated by a zinc-sensitive inhibitor that interacts with aconstitutively active transcription factor, MTF-1.

1994 • 351 citations

Chromatin structure and gene expression.

1996 • 339 citations

Adenovirus as an expression vector in muscle cells in vivo.

1992 • 301 citations

Adenovirus-mediated regulable target gene expression in vivo

1999 • 249 citations

Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains.

1995 • 244 citations

Activation domains of stably bound GAL4 derivatives alleviate repression of promoters by nucleosomes

1991 • 242 citations

Stopped at the border: boundaries and insulators

1999 • 222 citations

Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo

1996 • 214 citations

Human Adenovirus Vectors for Gene Transfer into Mammalian Cells

1997 • 185 citations

An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells

1987 • 149 citations

An enhancer-like element in the adenovirus E2 promoter contains sequences essential for uninduced and E1A-induced transcription.

1985 • 131 citations

The adenovirus type 5 E1A enhancer contains two functionally distinct domains: One is specific for E1A and the other modulates all early units in cis

1986 • 118 citations

Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes

1995 • 109 citations

cis and trans requirements for the selective packaging of adenovirus type 5 DNA

1992 • 108 citations

Dividing the empire: boundary chromatin elements delimit the territory of enhancers

1999 • 103 citations

Method for Multiple Portal Vein Infusions in Mice: Quantitation of Adenovirus-Mediated Hepatic Gene Transfer

1996 • 103 citations

The Adenovirus EIIA Enhancer

1989 • 100 citations

Functional Assessment of Two Vitamin D-responsive Elements in the Rat 25-Hydroxyvitamin D3 24-Hydroxylase Gene

1996 • 94 citations

DNA sequence of the deletion/insertion in early region 3 of Ad5 dl309

1995 • 82 citations

Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression.

1986 • 77 citations

Insulation of a conditionally expressed transgene in an adenoviral vector

1999 • 76 citations

Metal Regulatory Elements of the Mouse Metallothionein-I Gene

1987 • 69 citations

Persistence of recombinant adenovirus in vivo is not dependent on vector DNA replication

1997 • 66 citations

Suicide gene expression induced in tumour cells transduced with recombinant adenoviral, retroviral and plasmid vectors containing the ERBB2 promoter.

1996 • 64 citations

Cellular transcription factor binds to adenovirus early region promoters and to a cyclic AMP response element

1988 • 63 citations

The Chicken β-Globin 5′HS4 Boundary Element Blocks Enhancer-Mediated Suppression of Silencing

1999 • 63 citations

Interleukin 6 enhances a cellular activity that functionally substitutes for E1A protein in transactivation.

1991 • 62 citations

Modulation of the Specificity and Activity of a Cellular Promoter in an Adenoviral Vector

1997 • 60 citations

Redundant elements in the adenovirus type 5 inverted terminal repeat promote bidirectional transcriptionin Vitro and are important for virus growthin Vivo

1991 • 60 citations

Adenovirus chromatin structure at different stages of infection.

1981 • 60 citations

Cellular Promoters Incorporated into the Adenovirus Genome: Effects of Viral Regulatory Elements on Transcription Rates and Cell Specificity of Albumin and β-Globin Promoters

1986 • 48 citations

The Structure of Adenovirus Chromatin in Infected Cells

1985 • 47 citations

Far upstream sequences are required for efficient transcription from the adenovirus-2 E1A transcription unit

1983 • 42 citations

The Activity of the scs and scs’ Insulator Elements Is Not Dependent on Chromosomal Context

1997 • 40 citations

Targeting cell-specific gene expression with an adenovirus vector containing the lacZ gene under the control of the CFTR promoter.

1996 • 38 citations

Heart-Specific Targeting ofβ-Galactosidase by the Ventricle-Specific Cardiac Myosin Light Chain 2 Promoter Using Adenovirus Vectors

1998 • 36 citations

Cellular promoters incorporated into the adenovirus genome: effects of viral regulatory elements on transcription rates and cell specificity of albumin and beta-globin promoters.

1986 • 30 citations

The scs and scs′ Insulator Elements Impart a cis Requirement on Enhancer–Promoter Interactions

1998 • 30 citations

Psoralen-cross-linking study of the organization of intracellular adenovirus nucleoprotein complexes

1988 • 25 citations

The Adenovirus Inverted Terminal Repeat Functions as an Enhancer in a Cell-free System

1989 • 22 citations

Bent DNA in the Human Adenovirus Type 2 E1A Enhancer Is an Architectural Element for Transcription Stimulation

1996 • 18 citations

EIa-mediated stimulation of the adenovirus EIII promoter involves an enhancer element within the nearby EIIa promoter

1988 • 12 citations