The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

A nuclear DNA attachment element mediates elevated and position-independent gene activity

1989 • 597 citations

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1994 • 539 citations

An Exceptionally Conserved Transcriptional Repressor, CTCF, Employs Different Combinations of Zinc Fingers To Bind Diverged Promoter Sequences of Avian and Mammalian c-myc Oncogenes

1996 • 536 citations

An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.

1988 • 518 citations

Modular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site

1990 • 487 citations

DNA position-specific repression of transcription by a Drosophila zinc finger protein.

1992 • 418 citations

Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators

1998 • 403 citations

A group of scs elements function as domain boundaries in an enhancer-blocking assay.

1992 • 383 citations

Characterization of the chicken β-globin insulator

1997 • 381 citations

A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene.

1990 • 376 citations

Visualization of chromosomal domains with boundary element-associated factor BEAF-32

1995 • 321 citations

A drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation

1995 • 296 citations

CTCF, a Conserved Nuclear Factor Required for Optimal Transcriptional Activity of the Chicken c-myc Gene, Is an 11-Zn-Finger Protein Differentially Expressed in Multiple Forms

1993 • 271 citations

The 87A7 chromomere

1985 • 249 citations

Fab-7 functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex.

1996 • 237 citations

Stopped at the border: boundaries and insulators

1999 • 222 citations

Polycomb and Trithorax Group Proteins Mediate the Function of a Chromatin Insulator

1998 • 213 citations

CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms.

1993 • 198 citations

The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon.

1988 • 197 citations

The Zinc Finger Protein CTCF Binds to the APBβ Domain of the Amyloid β-Protein Precursor Promoter

1997 • 187 citations

Repression of hsp70 heat shock gene transcription by the suppressor of hairy-wing protein of Drosophila melanogaster.

1991 • 180 citations

The Fab-7 element of the bithorax complex attenuates enhancer-promoter interactions in the Drosophila embryo.

1996 • 166 citations

GAGA mediates the enhancer blocking activity of the eve promoter in the Drosophila embryo

1998 • 153 citations

An insulator element and condensed chromatin region separate the chicken β-globin locus from an independently regulated erythroid-specific folate receptor gene

1999 • 151 citations

Flexibility of the yeast alpha 2 repressor enables it to occupy the ends of its operator, leaving the center free.

1988 • 150 citations

Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes

1999 • 144 citations

Negative Protein 1, Which Is Required for Function of the Chicken Lysozyme Gene Silencer in Conjunction with Hormone Receptors, Is Identical to the Multivalent Zinc Finger Repressor CTCF

1997 • 133 citations

Genetic and molecular analysis of the gypsy chromatin insulator of Drosophila.

1996 • 124 citations

Synergistic activation of a human promoter in vivo by transcription factor Sp1.

1991 • 115 citations

Developmental Regulation of Topoisomerase II Sites and DNase I-Hypersensitive Sites in the Chicken β-Globin Locus

1990 • 108 citations

Dividing the empire: boundary chromatin elements delimit the territory of enhancers

1999 • 103 citations

An enhancer-blocking element between α and δ gene segments within the human T cell receptor α/δ locus

1997 • 103 citations

Interaction Between Mutations in the suppressor of Hairy wing and modifier of mdg4 Genes of Drosophila melunogaster Affecting the Phenotype of gypsy-Induced Mutations

1996 • 97 citations

Distance-independent inactivation of an enhancer by the suppressor of Hairy-wing DNA-binding protein of Drosophila.

1993 • 87 citations

Developmental regulation of topoisomerase II sites and DNase I-hypersensitive sites in the chicken beta-globin locus.

1990 • 66 citations

Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene

1997 • 62 citations

Chromatin boundaries: Punctuating the genome

1998 • 43 citations

The Repeat Organizer, a Specialized Insulator Element within the Intergenic Spacer of the Xenopus rRNA Genes

1997 • 37 citations

Dual promoter activation by the human beta-globinlocus control region.

1994 • 35 citations

Characterization of Functional Domains of the su(Hw) Protein That Mediate the Silencing Effect of mod(mdg4) Mutations

1997 • 26 citations

DNA sequences for typical ribosomal gene spacers from Xenopus laevis and Xenopus borealis

1987 • 19 citations