Cell cycle regulation and RNA polymerase II

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1997 • 4,531 citations

Principles of CDK regulation

1995 • 3,267 citations

A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

1998 • 1,213 citations

Molecular mechanism of nucleotide excision repair

1999 • 1,118 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Casein kinase 2: An ‘eminence grise’ in cellular regulation?

1990 • 920 citations

A human peptidyl–prolyl isomerase essential for regulation of mitosis

1996 • 891 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

1991 • 846 citations

Sequence-Specific and Phosphorylation-Dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism

1997 • 762 citations

The p53 Network

1998 • 731 citations

DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

1998 • 718 citations

Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro

1997 • 692 citations

Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

1997 • 542 citations

The INK4A/ARF locus and its two gene products

1999 • 532 citations

Identification of multiple cyclin subunits of human P-TEFb

1998 • 512 citations

Aberrant Expression of Mitotic Cdc2/Cyclin B1 Kinase in Degenerating Neurons of Alzheimer’s Disease Brain

1997 • 444 citations

Cdk-activating kinase complex is a component of human transcription factor TFIIH

1995 • 431 citations

Multiple Ras Effector Pathways Contribute to G1Cell Cycle Progression

1999 • 414 citations

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle

1993 • 402 citations

Temporal Regulation of RNA Polymerase II by Srb10 and Kin28 Cyclin-Dependent Kinases

1998 • 400 citations

Mitotic mechanisms in Alzheimer's disease?

1996 • 384 citations

Association of Cdk-activating kinase subunits with transcription factor TFIIH

1995 • 366 citations

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1996 • 359 citations

RNA polymerase II is an essential mRNA polyadenylation factor

1998 • 358 citations

The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation*

1999 • 358 citations

Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template.

1994 • 357 citations

Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosis.

1996 • 337 citations

Distinct Roles for CTD Ser-2 and Ser-5 Phosphorylation in the Recruitment and Allosteric Activation of Mammalian mRNA Capping Enzyme

1999 • 329 citations

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

1995 • 328 citations

UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells.

1996 • 313 citations

The RNA polymerase II holoenzyme and its implications for gene regulation

1995 • 297 citations

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.

1994 • 289 citations

Inhibition of RNA polymerase II as a trigger for the p53 response

1999 • 287 citations

UV-induced signal transduction

1997 • 277 citations

MCM proteins: evolution, properties, and role in DNA replication

1998 • 275 citations

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

1994 • 254 citations

Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM

1995 • 253 citations

Splicing Factors Associate with Hyperphosphorylated RNA Polymerase II in the Absence of Pre-mRNA

1997 • 245 citations

The cellular organization of gene expression

1998 • 243 citations

Phosphorylated RNA polymerase II stimulates pre-mRNA splicing

1999 • 239 citations

Alternative mechanisms of CAK assembly require an assembly factor or an Activating Kinase

1995 • 238 citations

NAT, a Human Complex Containing Srb Polypeptides that Functions as a Negative Regulator of Activated Transcription

1998 • 235 citations

MAT1 (‘menage à trois’) a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.

1995 • 235 citations

Stationary phase in Saccharomyces cerevisiae

1996 • 235 citations

U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle.

1994 • 227 citations

Growth-related Changes in Phosphorylation of Yeast RNA Polymerase II

1998 • 225 citations

Ultraviolet Radiation-induced Ubiquitination and Proteasomal Degradation of the Large Subunit of RNA Polymerase II

1998 • 221 citations

Cyclin K Functions as a CDK9 Regulatory Subunit and Participates in RNA Polymerase II Transcription

1999 • 221 citations

Regulation of transcription by proteins that control the cell cycle

1997 • 220 citations

The Cdk-Activating Kinase (CAK) from Budding Yeast

1996 • 220 citations

Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase II.

1988 • 212 citations

KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity

1995 • 208 citations

Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain.

1993 • 206 citations

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

1997 • 206 citations

Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents.

1993 • 201 citations

Mitotic regulation of TFIID: inhibition of activator-dependent transcription and changes in subcellular localization.

1996 • 200 citations

DNA Strand Breaks: the DNA Template Alterations That Trigger p53-Dependent DNA Damage Response Pathways

1994 • 198 citations

Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH

1997 • 195 citations

A protein phosphatase functions to recycle RNA polymerase II

1999 • 195 citations

Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity

1998 • 192 citations

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C.

1995 • 182 citations

Regulation of CDK7 substrate specificity by MAT1 and TFIIH

1997 • 177 citations

Mitotic phosphoepitopes precede paired helical filaments in Alzheimer’s disease

1998 • 177 citations

Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast.

1995 • 174 citations

A Cyclin-Dependent Kinase-Activating Kinase (CAK) in Budding Yeast Unrelated to Vertebrate CAK

1996 • 174 citations

p53 Is Phosphorylated by CDK7-Cyclin H in a p36^MAT1-Dependent Manner

1997 • 173 citations

Casein kinase II is required for transition of G0/G1, early G1, and G1/S phases of the cell cycle.

1994 • 172 citations

Civ1 (CAK In Vivo), a Novel Cdk-Activating Kinase

1996 • 172 citations

Rsp5 Ubiquitin-Protein Ligase Mediates DNA Damage-Induced Degradation of the Large Subunit of RNA Polymerase II in Saccharomyces cerevisiae

1999 • 169 citations

Promoter-Selective Transcriptional Defect in Cell Cycle Mutant ts13 Rescued by hTAF _II 250

1994 • 163 citations

Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.

1996 • 162 citations

RNA polymerase II as a control panel for multiple coactivator complexes

1999 • 155 citations

The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation

1999 • 154 citations

The CDK₇-cycH-p36 Complex of Transcription Factor IIH Phosphorylates p53, Enhancing Its Sequence-Specific DNA Binding Activity In Vitro

1997 • 152 citations

FCP1, the RAP74-Interacting Subunit of a Human Protein Phosphatase That Dephosphorylates the Carboxyl-terminal Domain of RNA Polymerase IIO

1998 • 144 citations

Yeast TAFII145 Required for Transcription of G1/S Cyclin Genes and Regulated by the Cellular Growth State

1997 • 143 citations

The Yeast Carboxyl-Terminal Repeat Domain Kinase CTDK-I Is a Divergent Cyclin–Cyclin-Dependent Kinase Complex

1995 • 140 citations

MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH.

1996 • 133 citations

Upregulation of cyclin T1/CDK9 complexes during T cell activation

1998 • 130 citations

Characterization of the Residues Phosphorylated in Vitro by Different C-terminal Domain Kinases

1998 • 126 citations

Identification of genes required for alpha 2 repression in Saccharomyces cerevisiae.

1995 • 123 citations

The Activity of COOH-terminal Domain Phosphatase Is Regulated by a Docking Site on RNA Polymerase II and by the General Transcription Factors IIF and IIB

1995 • 121 citations

Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases

1999 • 120 citations

Distribution of cytoskeletal proteins sharing a conserved phosphorylated epitope.

1986 • 118 citations

The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7

1998 • 106 citations

Nuclear translocation and carboxyl-terminal domain phosphorylation of RNA polymerase II delineate the two phases of zygotic gene activation in mammalian embryos

1997 • 102 citations

Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain

1999 • 99 citations

Heat shock induces transient p53-dependent cell cycle arrest at G1/S

1997 • 99 citations

The Sensitivity of Cockayne’s Syndrome Cells to DNA-Damaging Agents Is Not due to Defective Transcription-Coupled Repair of Active Genes

1996 • 96 citations

Inactivation of a Cdk2 Inhibitor during Interleukin 2-Induced Proliferation of Human T Lymphocytes

1994 • 94 citations

Human Cyclin K, a Novel RNA Polymerase II-Associated Cyclin Possessing Both Carboxy-Terminal Domain Kinase and Cdk-Activating Kinase Activity

1998 • 94 citations

Tat-associated Kinase (P-TEFb): a Component of Transcription Preinitiation and Elongation Complexes

1999 • 92 citations

Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.

1995 • 92 citations

The yeast UME5 gene regulates the stability of meiotic mRNAs in response to glucose.

1994 • 91 citations

MCM Proteins Are Associated with RNA Polymerase II Holoenzyme

1999 • 89 citations

TAF_II250-dependent transcription of cyclin A is directed by ATF activator proteins

1997 • 88 citations

Repression of TFIIH Transcriptional Activity and TFIIH-Associated cdk7 Kinase Activity at Mitosis

1998 • 87 citations

Phosphorylation of the carboxy-terminal repeat domain in RNA polymerase II by cyclin-dependent kinases is sufficient to inhibit transcription

1997 • 81 citations

Interplay between positive and negative elongation factors: drawing a new view of DRB

1998 • 81 citations

The ts13 Mutation in the TAF_II250 Subunit (CCG1) of TFIID Directly Affects Transcription of D-Type Cyclin Genes in Cells Arrested in G₁ at the Nonpermissive Temperature

1997 • 81 citations

A Ras-Dependent Pathway Regulates RNA Polymerase II Phosphorylation in Cardiac Myocytes: Implications for Cardiac Hypertrophy

1998 • 75 citations

Regulation of CAK kinase activity by p53

1998 • 75 citations

A hyperphosphorylated form of RNA polymerase II is the major interphase antigen of the phosphoprotein antibody MPM-2 and interacts with the peptidyl-prolyl isomerase Pin1

1999 • 74 citations

Enhanced phosphorylation of the C-terminal domain of RNA polymerase II upon serum stimulation of quiescent cells: possible involvement of MAP kinases.

1994 • 74 citations

Nuclear c-Abl is a COOH-terminal repeated domain (CTD)-tyrosine (CTD)-tyrosine kinase-specific for the mammalian RNA polymerase II: possible role in transcription elongation.

1999 • 69 citations

Tyrosine Phosphorylation of RNA Polymerase II Carboxyl-terminal Domain by the Abl-related Gene Product

1997 • 69 citations

Yeast Carboxyl-terminal Domain Kinase I Positively and Negatively Regulates RNA Polymerase II Carboxyl-terminal Domain Phosphorylation

1999 • 68 citations

Molecular Cloning and Chromosomal Localization of the Human Cyclin C (CCNC) and Cyclin E (CCNE) Genes: Deletion of theCCNCGene in Human Tumors

1996 • 66 citations

Stimulation of the DNA-dependent Protein Kinase by RNA Polymerase II Transcriptional Activator Proteins

1995 • 66 citations

Identification of a Binding Site in c-Abl Tyrosine Kinase for the C-Terminal Repeated Domain of RNA Polymerase II

1996 • 65 citations

Transcription factor IIH: A key player in the cellular response to DNA damage

1999 • 60 citations

Genetic Analysis of the Repetitive Carboxyl-Terminal Domain of the Largest Subunit of Mouse RNA Polymerase II

1988 • 60 citations

Transcription-independent phosphorylation of the RNA polymerase II C-terminal domain (CTD) involves ERK kinases (MEK1/2)

1999 • 59 citations

Heat-shock inactivation of the TFIIH-associated kinase and change in the phosphorylation sites on the C-terminal domain of RNA polymerase II

1997 • 58 citations

Phosphorylation of the RNA Polymerase II Largest Subunit during Xenopus laevis Oocyte Maturation

1997 • 58 citations

Regulated phosphorylation of the RNA polymerase II C-terminal domain (CTD)

1999 • 54 citations

Purification of an RNA Polymerase II Transcript Release Factor from Drosophila

1996 • 51 citations

The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250.

1995 • 51 citations

Activating Phosphorylation of the Kin28p Subunit of Yeast TFIIH by Cak1p

1999 • 50 citations

A Critical Role for Cyclin C in Promotion of the Hematopoietic Cell Cycle by Cooperation with c-Myc

1998 • 48 citations

Lack of Transcription-coupled Repair of Acetylaminofluorene DNA Adducts in Human Fibroblasts Contrasts Their Efficient Inhibition of Transcription

1998 • 44 citations

Phosphorylation State of the RNA Polymerase II C‐Terminal Domain (CTD) in Heat‐Shocked Cells

1995 • 42 citations

Mechanism of assembly of the RNA polymerase II preinitiation complex. Evidence for a functional interaction between the carboxyl-terminal domain of the largest subunit of RNA polymerase II and a high molecular mass form of the TATA factor.

1992 • 40 citations

Nuclear Extracts Lacking DNA-dependent Protein Kinase Are Deficient in Multiple Round Transcription

1999 • 39 citations

Fractions to Functions: RNA Polymerase II Thirty Years Later

1998 • 34 citations

Cytostellin distributes to nuclear regions enriched with splicing factors

1994 • 34 citations

Heat shock of HeLa cells inactivates a nuclear protein phosphatase specific for dephosphorylation of the C-terminal domain of RNA polymerase II

1999 • 34 citations

Recovery of the Yeast Cell Cycle from Heat Shock-induced G1 Arrest Involves a Positive Regulation of G1Cyclin Expression by the S Phase Cyclin Clb5

1999 • 32 citations

Is Cdk7/cyclin H/MAT1 the genuine cdk activating kinase in cycling xenopus egg extracts?

1997 • 31 citations

The Cycling of RNA Polymerase II during Transcription

1993 • 31 citations

Human Transcription Factor hTAF_II150 (CIF150) Is Involved in Transcriptional Regulation of Cell Cycle Progression

1999 • 31 citations

Rb interacts with TAFII250/TFIID through multiple domains

1997 • 25 citations

The Photoactivated Cross-linking of Recombinant C-terminal Domain to Proteins in a HeLa Cell Transcription Extract That Comigrate with Transcription Factors IIE and IIF

1995 • 24 citations

Transcription response and nucleotide excision repair

1998 • 24 citations

Cyclin-dependent Kinase Inhibitor p16INK4A Inhibits Phosphorylation of RNA Polymerase II by General Transcription Factor TFIIH

1998 • 24 citations

Recovery of RNA synthesis from the DHFR gene following UV-irradiation precedes the removal of photolesions from the transcribed strand

1999 • 22 citations

Regulation of protein kinase CKII during the cell division cycle.

1994 • 22 citations

Alternatively spliced cyclin C mRNA is widely expressed, cell cycle regulated, and encodes a truncated cyclin box.

1996 • 17 citations

Dynamics of RNA polymerase II localization during the cell cycle

1999 • 16 citations

Phosphorylation of the C-Terminal Domain of RNA Polymerase II by the Extracellular-Signal-Regulated Protein Kinase ERK2

1995 • 10 citations

Differential regulation of transcription of p21 and cyclin D1 conferred by TAF(II)250.

1997 • 10 citations

Phosphorylation of the carboxy‐terminal repeat domain in RNA polymerase II by cyclin‐dependent kinases is sufficient to inhibit transcription

1997 • 3 citations