Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

Antibodies, a laboratory manual

1989 • 12,929 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Mammalian G1 cyclins

1993 • 1,990 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

A family of human cdc2-related protein kinases.

1992 • 928 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

Isolation of Monoclonal Antibodies Specific for Human c-myc Proto-Oncogene Product

1985 • 788 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

Creative blocks: cell-cycle checkpoints and feedback controls

1992 • 686 citations

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

1992 • 638 citations

A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase

1994 • 636 citations

Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution

1994 • 591 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

The cell cycle: an introduction

1994 • 466 citations

Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.

1992 • 459 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1991 • 439 citations

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

1993 • 391 citations

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

1993 • 377 citations

cdc2 phosphorylation is required for its interaction with cyclin.

1991 • 338 citations

CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.

1993 • 326 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

1991 • 318 citations

Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.

1994 • 299 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae

1992 • 296 citations

S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P34cdc28

1992 • 290 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5

1994 • 275 citations

Cyclin A is required in S phase in normal epithelial cells

1992 • 273 citations

Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes.

1992 • 271 citations

Activation of the various cyclin/cdc2 protein kinases

1993 • 253 citations

Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15.

1993 • 247 citations

Targets of cyclin-dependent protein kinases

1993 • 240 citations

Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2

1992 • 231 citations

Nuclear export of proteins: The role of nuclear retention

1993 • 209 citations

Protein localization to the nucleolus: a search for targeting domains in nucleolin

1993 • 209 citations

Casein kinase II is a predominantly nuclear enzyme.

1992 • 208 citations

A template for the protein kinase family

1993 • 196 citations

Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein

1988 • 189 citations

Coupling M phase and S phase: Controls maintaining the dependence of mitosis on chromosome replication

1991 • 183 citations

[16] Peptide mapping in one dimension by limited proteolysis of sodium dodecyl sulfate-solubilized proteins

1983 • 182 citations

Cyclins and their partners: from a simple idea to complicated reality.

1991 • 159 citations

Cyclin-dependent kinases: a new cell cycle motif?

1991 • 148 citations

Dephosphorylation of cdc2 on threonine 161 is required for cdc2 kinase inactivation and normal anaphase.

1992 • 145 citations

Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2.

1993 • 120 citations

Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle.

1992 • 119 citations

Dephosphorylation of human p34^cdc2 kinase on both Thr‐14 and Tyr‐15 by human cdc25B phosphatase

1993 • 104 citations

Mitotic control

1991 • 104 citations

A Monoclonal Antibody Against the PSTAIR Sequence of p34^cdc2, Catalytic Subunit of Maturation‐Promoting Factor and Key Regulator of the Cell Cycle

1991 • 103 citations

Protein kinase regulation: insights from crystal structure analysis

1994 • 100 citations

p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes.

1990 • 99 citations

Regulation of Cyclin D-Dependent Kinase 4 (cdk4) by cdk4-activating kinase

1994 • 96 citations

Nuclear localization of vertebrate cyclin a correlates with its ability to form complexes with cdk catalytic subunits

1993 • 90 citations

Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines.

1993 • 89 citations

The Kin28 Protein Kinase is Associated with a Cyclin in Saccharomyces cerevisiae

1993 • 77 citations

Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.

1993 • 76 citations

Novel protein kinases expressed in human breast cancer

1993 • 74 citations

cdc2 activation: the interplay of cyclin binding and Thr161 phosphorylation

1993 • 72 citations

Regulation of p34cdc2 protein kinase: new insights into protein phosphorylation and the cell cycle

1991 • 65 citations

Cell cycle regulation of vertebrate p34cdc2 activity: identification of Thr161 as an essential in vivo phosphorylation site.

1992 • 50 citations

Vertebrate p34cdc2 phosphorylation site mutants: effects upon cell cycle progression in the fission yeast Schizosaccharomyces pombe

1992 • 41 citations

Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation.

1991 • 31 citations

Heterogeneous binding of high mobility group chromosomal proteins to nuclei

1981 • 28 citations

Novel CDC2-related protein kinases produced in murine hematopoietic stem cells

1993 • 26 citations

Bring on the phosphatases

1993 • 17 citations

Distinct forms of human CDC2 identified by novel monoclonal antibodies

1992 • 8 citations

Signal Transduction to the Cell Nucleus

1992 • 8 citations