Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity

Principles of CDK regulation

1995 • 3,267 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

1995 • 918 citations

Developmental genetics of oogenesis

1993 • 858 citations

A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase

1994 • 636 citations

Structural basis of cyclin-dependent kinase activation by phosphorylation

1996 • 585 citations

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation

1994 • 543 citations

Identification and behavior of epithelial stem cells in the Drosophila ovary

1995 • 460 citations

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

1994 • 432 citations

Cdk-activating kinase complex is a component of human transcription factor TFIIH

1995 • 431 citations

The roles of Drosophila cyclins A and B in mitotic control

1990 • 429 citations

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

1994 • 426 citations

Expression and function of Drosophila cyclin a during embryonic cell cycle progression

1989 • 399 citations

The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues.

1993 • 391 citations

Developmental Control of Cell Cycle Regulators: A Fly's Perspective

1996 • 383 citations

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

1993 • 377 citations

Association of Cdk-activating kinase subunits with transcription factor TFIIH

1995 • 366 citations

CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15.

1993 • 326 citations

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

1994 • 301 citations

The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S-phase completion.

1996 • 270 citations

A cyclin associated with the CDK-activating kinase MO15

1994 • 267 citations

Genes controlling essential cell-cycle functions in Drosophila melanogaster.

1989 • 255 citations

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

1994 • 254 citations

Alternative mechanisms of CAK assembly require an assembly factor or an Activating Kinase

1995 • 238 citations

MAT1 (‘menage à trois’) a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.

1995 • 235 citations

The Cdk-Activating Kinase (CAK) from Budding Yeast

1996 • 220 citations

KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity

1995 • 208 citations

Taking a new TAK on Tat transactivation

1997 • 206 citations

In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.

1995 • 200 citations

Activation of Cyclin-Dependent Kinase 4 (cdk4) by Mouse MO15-Associated Kinase

1994 • 197 citations

A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation

1995 • 194 citations

Requirement for TFIIH kinase activity in transcription by RNA polymerase II

1995 • 189 citations

TheKIN28Gene is Required both for RNA Polymerase II Mediated Transcription and Phosphorylation of the Rpb1p CTD

1995 • 185 citations

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C.

1995 • 182 citations

A Cyclin-Dependent Kinase-Activating Kinase (CAK) in Budding Yeast Unrelated to Vertebrate CAK

1996 • 174 citations

Civ1 (CAK In Vivo), a Novel Cdk-Activating Kinase

1996 • 172 citations

Cyclin-dependent kinase 7: at the cross-roads of transcription, DNA repair and cell cycle control?

1996 • 145 citations

Effects of Phosphorylation by CAK on Cyclin Binding by CDC2 and CDK2

1995 • 145 citations

MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH.

1996 • 133 citations

Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors.

1995 • 123 citations

Genetic analysis of the Drosophila cdc2 homolog

1993 • 107 citations

A Cdc2 dependent checkpoint maintains diploidy in Drosophila

1996 • 97 citations

The Drosophila sex determination gene snf encodes a nuclear protein with sequence and functional similarity to the mammalian U1A snRNP protein.

1994 • 92 citations

Identification of a cdk-activating kinase in fission yeast.

1995 • 91 citations

Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: Implications for cdc2 + protein structure and function

1989 • 88 citations

Schizosaccharomyces pombe Mop1-Mcs2 is related to mammalian CAK.

1995 • 85 citations

Cell cycle regulation of the p34cdc2/p33cdk2-activating kinase p40MO15

1994 • 80 citations

The Kin28 Protein Kinase is Associated with a Cyclin in Saccharomyces cerevisiae

1993 • 77 citations

The Drosophila gene morula inhibits mitotic functions in the endo cell cycle and the mitotic cell cycle

1997 • 67 citations

A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases.

1994 • 60 citations

Expression and activity of p40MO15, the catalytic subunit of cdk-activating kinase, during Xenopus oogenesis and embryogenesis.

1994 • 57 citations

Dmcdc2 kinase is required for both meiotic divisions during Drosophila spermatogenesis and is activated by the Twine/cdc25 phosphatase

1995 • 46 citations

Cdks and the Drosophila cell cycle

1997 • 39 citations

Is Cdk7/cyclin H/MAT1 the genuine cdk activating kinase in cycling xenopus egg extracts?

1997 • 31 citations

The Drosophila melanogaster homolog of the mammalian MAPK-activated protein kinase-2 (MAPKAPK-2) lacks a proline-rich N terminus

1995 • 19 citations

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

1995 • 18 citations

CAK in TFIIH: crucial connection or confounding coincidence?

1996 • 12 citations

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

1995 • 7 citations

Deleted Work

1955 • 0 citations