Heat-shock inactivation of the TFIIH-associated kinase and change in the phosphorylation sites on the C-terminal domain of RNA polymerase II

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

RNA POLYMERASE II

1991 • 729 citations

Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases

1985 • 670 citations

RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis

1986 • 524 citations

Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II

1996 • 498 citations

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

1994 • 432 citations

Cdk-activating kinase complex is a component of human transcription factor TFIIH

1995 • 431 citations

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

1994 • 426 citations

A kinase–cyclin pair in the RNA polymerase II holoenzyme

1995 • 418 citations

Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses.

1992 • 417 citations

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

1992 • 407 citations

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II.

1992 • 367 citations

Association of Cdk-activating kinase subunits with transcription factor TFIIH

1995 • 366 citations

RNA Polymerase B (II) And General Transcription Factors

1990 • 355 citations

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1994 • 325 citations

A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix.

1996 • 324 citations

The RNA polymerase II holoenzyme and its implications for gene regulation

1995 • 297 citations

Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome

1995 • 280 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

Alternative mechanisms of CAK assembly require an assembly factor or an Activating Kinase

1995 • 238 citations

MAT1 (‘menage à trois’) a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.

1995 • 235 citations

Inhibition of in Vivo and in Vitro Transcription by Monoclonal Antibodies Prepared against Wheat Germ RNA Polymerase II That React with the Heptapeptide Repeat of Eukaryotic RNA Polymerase II

1989 • 228 citations

The multiple roles of transcription/repair factor TFIIH

1996 • 227 citations

Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein

1992 • 219 citations

KIN28 Encodes a C-Terminal Domain Kinase That Controls mRNA Transcription in Saccharomyces cerevisiae but Lacks Cyclin-Dependent Kinase-Activating Kinase (CAK) Activity

1995 • 208 citations

In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.

1995 • 200 citations

CTD kinase associated with yeast RNA polymerase II initiation factor b

1991 • 199 citations

A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation

1995 • 194 citations

Requirement for TFIIH kinase activity in transcription by RNA polymerase II

1995 • 189 citations

TheKIN28Gene is Required both for RNA Polymerase II Mediated Transcription and Phosphorylation of the Rpb1p CTD

1995 • 185 citations

The Transcriptional Elongation Inhibitor 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole Inhibits Transcription Factor IIH-associated Protein Kinase

1995 • 178 citations

Postinitiation Transcriptional Control in Drosophila melanogaster

1990 • 177 citations

Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing.

1993 • 175 citations

A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID

1992 • 170 citations

Protein Denaturation during Heat Shock and Related Stress

1989 • 166 citations

TFIIH: a key component in multiple DNA transactions

1996 • 160 citations

Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting.

1991 • 159 citations

RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection

1994 • 152 citations

The Yeast Carboxyl-Terminal Repeat Domain Kinase CTDK-I Is a Divergent Cyclin–Cyclin-Dependent Kinase Complex

1995 • 140 citations

The multiple roles of transcription/repair factor TFIIH

1996 • 136 citations

Phosphorylation of the C-terminal domain of RNA polymerase II

1995 • 133 citations

MAT1, cdk7 and cyclin H form a kinase complex which is UV light-sensitive upon association with TFIIH.

1996 • 133 citations

A carboxyl-terminal-domain kinase associated with RNA polymerase II transcription factor delta from rat liver.

1992 • 124 citations

RNA polymerase II pauses at the 5' end of the transcriptionally induced Drosophila hsp70 gene.

1991 • 124 citations

Inhibitors of transcription such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and isoquinoline sulfonamide derivatives (H-8 and H-7) promote dephosphorylation of the carboxyl-terminal domain of RNA polymerase II largest subunit.

1994 • 122 citations

The Activity of COOH-terminal Domain Phosphatase Is Regulated by a Docking Site on RNA Polymerase II and by the General Transcription Factors IIF and IIB

1995 • 121 citations

Regulated transcription of the genes for actin and heat-shock proteins in culture drosophila cells

1981 • 107 citations

Monoclonal antibody directed against RNA polymerase II of Drosophila melanogaster

1980 • 105 citations

Postinitiation transcriptional control in Drosophila melanogaster.

1990 • 95 citations

The nuclear matrix protein p255 is a highly phosphorylated form of RNA polymerase II largest subunit which associates with spliceosomes

1996 • 90 citations

Heat-shock-induced denaturation of proteins. Characterization of the insolubilization of the interferon-induced p68 kinase

1991 • 83 citations

Thermostability of a Nuclear‐Targeted Luciferase Expressed in Mammalian Cells

1995 • 77 citations

Enhanced phosphorylation of the C-terminal domain of RNA polymerase II upon serum stimulation of quiescent cells: possible involvement of MAP kinases.

1994 • 74 citations

Multifunctional RNA polymerase II initiation factor delta from rat liver. Relationship between carboxyl-terminal domain kinase, ATPase, and DNA helicase activities

1993 • 68 citations

Identification of a Binding Site in c-Abl Tyrosine Kinase for the C-Terminal Repeated Domain of RNA Polymerase II

1996 • 65 citations

TFIIH: a link between transcription, DNA repair and cell cycle regulation

1995 • 64 citations

Interplay of positive and negative effectors in function of the C-terminal repeat domain of RNA polymerase II.

1994 • 64 citations

Phosphorylation of the RNA polymerase II largest subunit during heat shock and inhibition of transcription in hela cells

1994 • 57 citations

Complete sequence of the human RNA polymerase II largest subunit

1992 • 55 citations

Characterization of a heat shock-induced insoluble complex in the nuclei of cells

1987 • 54 citations

[23] M phase-specific cdc2 kinase: Preparation from Starfish oocytes and properties

1991 • 53 citations

Purification of RNA polymerase IIO from calf thymus.

1988 • 50 citations

RNA Polymerase II Pauses at the 5′ End of the Transcriptionally Induced Drosophila hsp70 Gene

1991 • 47 citations

The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/Y6.U5]tri-snRNP particle

1995 • 46 citations

Heat Shock-Induced Interactions of Heat Shock Transcription Factor and the Human hsp70 Promoter Examined by In Vivo Footprinting

1991 • 45 citations

Production and Excision of 5′,6′-dihydroxydihydrothymine Type Products in the DNA of Preheated Cells

1978 • 44 citations

Heat Shock-induced Appearance of RNA Polymerase II in Karyoskeletal Protein-enriched (Nuclear “Matrix”) Fractions Correlates with Transcriptional Shutdown in Drosophila melanogaster

1989 • 43 citations

Phosphorylation State of the RNA Polymerase II C‐Terminal Domain (CTD) in Heat‐Shocked Cells

1995 • 42 citations

Colocalization of a high molecular mass phosphoprotein of the nuclear matrix (p255) with spliceosomes

1995 • 40 citations

Initial characterization of heat‐induced excess nuclear proteins in HeLa cells

1992 • 39 citations

Monoclonal antibody CC-3 recognizes phosphoproteins in interphase and mitotic cells

1991 • 28 citations

Phosphorylation dependence of the initiation of productive transcription of balbiani ring 2 genes in living cells

1996 • 28 citations

Different Carboxyl-terminal Domain Kinase Activities Are Induced by Heat-shock and Arsenite.

1995 • 23 citations

Ccl1, a cyclin associated with protein kinase Kin28, controls the phosphorylation of RNA polymerase II largest subunit and mRNA transcription.

1996 • 22 citations

The RNA polymerase II carboxy-terminal domain: links to a bigger and better 'holoenzyme'?

1995 • 20 citations

A positive addition to a negative tail's tale.

1993 • 16 citations

Heat-shock treatment selectively affects induction and repair of cyclobutane pyrimidine dimers in transcriptionally active genes in ultraviolet-irradiated human fibroblasts.

1993 • 15 citations

Poliovirus-induced modification of host cell RNA polymerase IIO is prevented by cycloheximide and zinc.

1988 • 12 citations

Heat-Shock Treatment Selectively Affects Induction and Repair of Cyclobutane Pyrimidine Dimers in Transcriptionally Active Genes in Ultraviolet-Irradiated Human Fibroblasts

1993 • 11 citations