Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Specific Inhibition of Nuclear RNA Polymerase II by α-Amanitin

1970 • 856 citations

RNA POLYMERASE II

1991 • 729 citations

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

1981 • 725 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

Visualization of focal sites of transcription within human nuclei.

1993 • 656 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

1993 • 541 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Inhibition of RNA synthesis by actinomycin D: Characteristic dose‐response of different RNA species

1970 • 531 citations

Associations between distinct pre-mRNA splicing components and the cell nucleus.

1991 • 523 citations

Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies

1992 • 402 citations

Initiation of Transcription by RNA Polymerase II: A Multi-step Process

1993 • 390 citations

The Ultrastructural Visualization of Nucleolar and Extranucleolar RNA Synthesis and Distribution

1980 • 344 citations

A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.

1991 • 344 citations

A Three-Dimensional View of Precursor Messenger RNA Metabolism Within the Mammalian Nucleus

1993 • 335 citations

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1994 • 325 citations

Tails of RNA polymerase II

1990 • 320 citations

The nonphosphorylated form of RNA polymerase II preferentially associates with the preinitiation complex.

1991 • 319 citations

Ultrastructural distribution of nuclear ribonucleoproteins as visualized by immunocytochemistry on thin sections.

1984 • 306 citations

Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus.

1991 • 300 citations

Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.

1987 • 288 citations

Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription.

1986 • 285 citations

Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription

1994 • 277 citations

In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism

1993 • 272 citations

The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa

1989 • 236 citations

Localisation of rapidly and slowly labelled nuclear RNA as visualized by high resolution autoradiography

1971 • 233 citations

Inhibition of in Vivo and in Vitro Transcription by Monoclonal Antibodies Prepared against Wheat Germ RNA Polymerase II That React with the Heptapeptide Repeat of Eukaryotic RNA Polymerase II

1989 • 228 citations

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro

1989 • 225 citations

Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

1990 • 225 citations

Immunoelectron microscopic localization of snRNPs

1984 • 208 citations

The inhibition of DRB (5,6-dichloro-1-β-d-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells

1976 • 204 citations

Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors

1994 • 189 citations

Localization and characterization of newly synthesized nuclear RNA in isolated rat hepatocytes

1976 • 184 citations

Small nuclear ribonucleoproteins and heterogeneous nuclear ribonucleoproteins in the amphibian germinal vesicle: loops, spheres, and snurposomes.

1991 • 182 citations

Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcription.

1990 • 178 citations

Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription

1993 • 176 citations

Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing.

1993 • 175 citations

Mapping of B cell epitopes on small nuclear ribonucleoproteins that react with human autoantibodies as well as with experimentally-induced mouse monoclonal antibodies.

1989 • 164 citations

Phosphorylation of eukaryotic DNA-dependent RNA polymerase. Identification of calf thymus RNA polymerase subunits phosphorylated by two purified protein kinases, correlation with in vivo sites of phosphorylation in HeLa cell RNA polymerase II.

1981 • 159 citations

RNA polymerase II is aberrantly phosphorylated and localized to viral replication compartments following herpes simplex virus infection

1994 • 152 citations

U1 and U2 small nuclear RNAs are present in nuclear speckles.

1992 • 141 citations

Intranuclear localization of snRNP antigens.

1986 • 140 citations

RNA contacts subunits IIo and IIc in HeLa RNA polymerase II transcription complexes.

1986 • 126 citations

Action of dichlorobenzimidazole riboside on RNA synthesis in L-929 and HeLa cells.

1976 • 125 citations

Immunoelectron microscope visualization of nuclear ribonucleoprotein antigens within spread transcription complexes.

1986 • 123 citations

Positive patches and negative noodles: linking RNA processing to transcription?

1993 • 117 citations

Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit

1991 • 117 citations

Association of individual hnRNP proteins and snRNPs with nascent transcripts.

1993 • 113 citations

Monoclonal antibody directed against RNA polymerase II of Drosophila melanogaster

1980 • 105 citations

Distribution of the 70K U1 RNA-associated protein during interphase and mitosis: correlation with other U RNP particles and proteins of the nuclear matrix

1986 • 94 citations

Spliceosomes and Snurposomes

1991 • 85 citations

RNA travel: Tracks from DNA to cytoplasm

1993 • 82 citations

RNA polymerases IIA and IIO have distinct roles during transcription from the TATA-less murine dihydrofolate reductase promoter.

1993 • 81 citations

Transcription-dependent localization of U1 and U2 small nuclear ribonucleoproteins at major sites of gene activity in polytene chromosomes

1984 • 77 citations

Ultrastructural localization of transcription sites and of RNA distribution during the cell cycle of synchronized CHO cells

1978 • 73 citations

Nuclear organization of splicing small nuclear ribonucleoproteins in adenovirus-infected cells

1993 • 64 citations

A normally masked nuclear matrix antigen that appears at mitosis on cytoskeleton filaments adjoining chromosomes, centrioles, and midbodies.

1992 • 63 citations

Phosphorylation of the RNA polymerase II largest subunit during heat shock and inhibition of transcription in hela cells

1994 • 57 citations

Cytostellin: A novel, highly conserved protein that undergoes continuous redistribution during the cell cycle

1992 • 57 citations

RNA polymerase II transcription cycles

1993 • 47 citations

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits a HeLa protein kinase that phosphorylates an RNA polymerase II-derived peptide

1989 • 39 citations

Cytostellin distributes to nuclear regions enriched with splicing factors

1994 • 34 citations

Visualization of RNA transcription and processing.

1991 • 32 citations

Visualization of RNA transcription and processing.

1991 • 20 citations

Preferential distribution of active RNA polymerase II molecules in the nuclear periphery.

1991 • 17 citations

Digestion of Proteins in Gels for Sequence Analysis

1995 • 6 citations