Yeast Carboxyl-terminal Domain Kinase I Positively and Negatively Regulates RNA Polymerase II Carboxyl-terminal Domain Phosphorylation

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1997 • 4,531 citations

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

1989 • 2,140 citations

Transcriptional regulation

1991 • 893 citations

Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro

1997 • 692 citations

Extensive homology among the largest subunits of eukaryotic and prokaryotic RNA polymerases

1985 • 670 citations

Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase

1996 • 645 citations

Stationary phase in the yeast Saccharomyces cerevisiae

1993 • 594 citations

Purification of P-TEFb, a Transcription Factor Required for the Transition into Productive Elongation

1995 • 544 citations

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

1997 • 539 citations

Identification of multiple cyclin subunits of human P-TEFb

1998 • 512 citations

Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II

1996 • 498 citations

The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

1994 • 432 citations

Cdk-activating kinase complex is a component of human transcription factor TFIIH

1995 • 431 citations

Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

1994 • 426 citations

A kinase–cyclin pair in the RNA polymerase II holoenzyme

1995 • 418 citations

Stress signaling in yeast

1995 • 415 citations

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

1992 • 407 citations

Temporal Regulation of RNA Polymerase II by Srb10 and Kin28 Cyclin-Dependent Kinases

1998 • 400 citations

Association of Cdk-activating kinase subunits with transcription factor TFIIH

1995 • 366 citations

A unique structure at the carboxyl terminus of the largest subunit of eukaryotic RNA polymerase II.

1985 • 346 citations

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

1996 • 341 citations

Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor

1995 • 338 citations

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

1995 • 328 citations

Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation

1994 • 325 citations

Tails of RNA polymerase II

1990 • 320 citations

Control of formation of two distinct classes of RNA polymerase II elongation complexes.

1992 • 295 citations

Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.

1987 • 288 citations

Conserved Structures of Mediator and RNA Polymerase II Holoenzyme

1999 • 272 citations

Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain

1996 • 255 citations

Construction and analysis of yeast RNA polymerase II CTD deletion and substitution mutations.

1995 • 239 citations

The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa

1989 • 236 citations

Stationary phase in Saccharomyces cerevisiae

1996 • 235 citations

Growth-related Changes in Phosphorylation of Yeast RNA Polymerase II

1998 • 225 citations

CTD kinase associated with yeast RNA polymerase II initiation factor b

1991 • 199 citations

RNA Polymerase II Holoenzymes and Subcomplexes

1998 • 197 citations

Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing.

1993 • 175 citations

Identification of a Cyclin Subunit Required for the Function ofDrosophila P-TEFb

1998 • 171 citations

CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae.

1991 • 170 citations

Pre-mRNA Processing and the CTD of RNA Polymerase II: The Tail That Wags the Dog?

1997 • 165 citations

Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.

1996 • 162 citations

A CTD function linking transcription to splicing

1997 • 160 citations

Two glycogen synthase isoforms in Saccharomyces cerevisiae are coded by distinct genes that are differentially controlled

1991 • 154 citations

An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae

1997 • 145 citations

FCP1, the RAP74-Interacting Subunit of a Human Protein Phosphatase That Dephosphorylates the Carboxyl-terminal Domain of RNA Polymerase IIO

1998 • 144 citations

The Yeast Carboxyl-Terminal Repeat Domain Kinase CTDK-I Is a Divergent Cyclin–Cyclin-Dependent Kinase Complex

1995 • 140 citations

Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.

1994 • 133 citations

Functional Relationships of Srb10-Srb11 Kinase, Carboxy-Terminal Domain Kinase CTDK-I, and Transcriptional Corepressor Ssn6-Tup1

1998 • 126 citations

Characterization of the Residues Phosphorylated in Vitro by Different C-terminal Domain Kinases

1998 • 126 citations

A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II.

1989 • 123 citations

Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases

1999 • 120 citations

Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit

1991 • 117 citations

Positive patches and negative noodles: linking RNA processing to transcription?

1993 • 117 citations

Transcription units as RNA processing units

1997 • 110 citations

The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7

1998 • 106 citations

Modulation of RNA Polymerase II Elongation Efficiency by C-terminal Heptapeptide Repeat Domain Kinase I

1997 • 97 citations

Tat-associated Kinase (P-TEFb): a Component of Transcription Preinitiation and Elongation Complexes

1999 • 92 citations

Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II.

1996 • 91 citations

Control of Saccharomyces cerevisiae Catalase T Gene (CTT1) Expression by Nutrient Supply via the RAS-Cyclic AMP Pathway

1989 • 87 citations

Phosphorylation of the carboxy-terminal repeat domain in RNA polymerase II by cyclin-dependent kinases is sufficient to inhibit transcription

1997 • 81 citations

Control of Saccharomyces cerevisiae catalase T gene (CTT1) expression by nutrient supply via the RAS-cyclic AMP pathway.

1989 • 58 citations

The refolding activity of the yeast heat shock proteins Ssa1 and Ssa2 defines their role in protein translocation.

1996 • 50 citations

Suppression of an Hsp70 Mutant Phenotype in Saccharomyces cerevisiae through Loss of Function of the Chromatin Component Sin1p/Spt2p

1998 • 17 citations

Partial Truncation of the Yeast RNA Polymerase II Carboxyl-terminal Domain Preferentially Reduces Expression of Glycolytic Genes

1995 • 16 citations