DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs

Antibodies, a laboratory manual

1989 • 12,929 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Multiple sequence alignment with hierarchical clustering

1988 • 5,250 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

1984 • 2,728 citations

The role of general initiation factors in transcription by RNA polymerase II

1996 • 1,001 citations

Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitro

1997 • 692 citations

The RNA polymerase II molecule at the 5′ end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged

1988 • 662 citations

Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase

1996 • 645 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

Purification of P-TEFb, a Transcription Factor Required for the Transition into Productive Elongation

1995 • 544 citations

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

1997 • 539 citations

Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II

1996 • 498 citations

Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae

1998 • 460 citations

Evidence That Spt6p Controls Chromatin Structure by a Direct Interaction with Histones

1996 • 352 citations

Elongin (SIII): A Multisubunit Regulator of Elongation by RNA Polymerase II

1995 • 320 citations

Separation and characterization of factors mediating accurate transcription by RNA polymerase II.

1982 • 314 citations

HIV-1 Tat protein promotes formation of more-processive elongation complexes.

1991 • 295 citations

Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription.

1986 • 285 citations

The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region.

1992 • 266 citations

5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro

1989 • 225 citations

Polymerase II Promoter Activation: Closed Complex Formation and ATP-Driven Start Site Opening

1992 • 220 citations

Transcriptional antitermination

1993 • 216 citations

Taking a new TAK on Tat transactivation

1997 • 206 citations

Activator-dependent regulation of transcriptional pausing on nucleosomal templates.

1996 • 205 citations

The inhibition of DRB (5,6-dichloro-1-β-d-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells

1976 • 204 citations

HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors.

1992 • 195 citations

TAFII250 Is a Bipartite Protein Kinase That Phosphorylates the Basal Transcription Factor RAP74

1996 • 194 citations

Dynamic interaction between a Drosophila transcription factor and RNA polymerase II.

1989 • 191 citations

Requirement for TFIIH kinase activity in transcription by RNA polymerase II

1995 • 189 citations

Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo.

1992 • 182 citations

SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat.

1991 • 179 citations

Requirement for E. coli NusG protein in factor-dependent transcription termination

1992 • 179 citations

The Transcriptional Elongation Inhibitor 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole Inhibits Transcription Factor IIH-associated Protein Kinase

1995 • 178 citations

Phosphorylation of C-terminal domain of RNA polymerase II is not required in basal transcription

1993 • 176 citations

SPT4, SPT5 and SPT6 interactions: effects on transcription and viability in Saccharomyces cerevisiae.

1992 • 176 citations

Role of the mammalian transcription factors IIF, IIS, and IIX during elongation by RNA polymerase II.

1991 • 152 citations

KOW: a novel motif linking a bacterial transcription factor with ribosomal proteins

1996 • 142 citations

The RNA polymerase II general elongation factors

1996 • 133 citations

Novel mechanism and factor for regulation by HIV-1 Tat.

1995 • 128 citations

NusG, a new Escherichia coli elongation factor involved in transcriptional antitermination by the N protein of phage lambda.

1992 • 127 citations

RNA polymerase II transcription factor SIII. I. Identification, purification, and properties.

1993 • 127 citations

Action of dichlorobenzimidazole riboside on RNA synthesis in L-929 and HeLa cells.

1976 • 125 citations

RNA polymerase II pauses at the 5' end of the transcriptionally induced Drosophila hsp70 gene.

1991 • 124 citations

A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription.

1995 • 123 citations

Elongation factor NusG interacts with termination factor rho to regulate termination and antitermination of transcription.

1993 • 121 citations

Mechanism of action of DRB

1983 • 117 citations

Ribofuranosyl‐benzimidazole derivatives as inhibitors of casein kinase‐2 and casein kinase‐1

1990 • 115 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 113 citations

Purification of a factor from Ehrlich ascites tumor cells specifically stimulating RNA polymerase II

1976 • 107 citations

The RNA polymerase II general elongation factors

1996 • 107 citations

5,6-Dichloro-1-β-D-Ribofuranosylbenzimidazole Inhibits Initiation of Nuclear Heterogeneous RNA Chains in HeLa Cells

1976 • 106 citations

cDNA Cloning of Transcription Factor E4TF1 Subunits with Ets and Notch Motifs

1993 • 99 citations

Isoquinolinesulfonamides, Novel and Potent Inhibitors of Cyclic Nucleotide-Dependent Protein Kinase and Protein Kinase C

1984 • 98 citations

RNA polymerase II transcription factor SIII. II. Functional properties and role in RNA chain elongation.

1993 • 98 citations

Escherichia coli NusG protein stimulates transcription elongation rates in vivo and in vitro

1995 • 97 citations

Inhibition of Balbiani ring RNA synthesis at the initiation level.

1975 • 97 citations

A protein-RNA interaction network facilitates the template-independent cooperative assembly on RNA polymerase of a stable antitermination complex containing the lambda N protein.

1995 • 95 citations

Sequence of general transcription factor TFIIB and relationships to other initiation factors.

1991 • 94 citations

NusG is required to overcome a kinetic limitation to Rho function at an intragenic terminator.

1995 • 67 citations

Nucleolar necklaces in chick embryo fibroblast cells. I. Formation of necklaces by dichlororibobenzimidazole and other adenosine analogues that decrease RNA synthesis and degrade preribosomes.

1975 • 66 citations

47 Analysis of SPT Genes: A Genetic Approach toward Analysis of TFIID, Histones, and Other Transcription Factors of Yeast

1992 • 65 citations

Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID tau).

1992 • 64 citations

Role of the Mammalian Transcription Factors IIF, IIS, and IIX during Elongation by RNA Polymerase II

1991 • 63 citations

TFIIH Functions in Regulating Transcriptional Elongation by RNA Polymerase II in Xenopus Oocytes

1996 • 61 citations

Molecular and genetic characterization of SPT4, a gene important for transcription initiation in Saccharomyces cerevisiae

1993 • 61 citations

A tentative initiation inhibitor of chromosomal heterogeneous RNA synthesis

1974 • 61 citations

Dynamic Interaction between a Drosophila Transcription Factor and RNA Polymerase II

1989 • 53 citations

SPT5, an Essential Gene Important for Normal Transcription in Saccharomyces cerevisiae, Encodes an Acidic Nuclear Protein with a Carboxy-Terminal Repeat

1991 • 51 citations

cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs.

1993 • 48 citations

RNA Polymerase II Pauses at the 5′ End of the Transcriptionally Induced Drosophila hsp70 Gene

1991 • 47 citations

Affinity purification of transcription factor IIA from HeLa cell nuclear extracts.

1991 • 43 citations

The HIP1 Initiator Element Plays a Role in Determining the In Vitro Requirement of the Dihydrofolate Reductase Gene Promoter for the C-Terminal Domain of RNA Polymerase II

1992 • 42 citations

Initiation inhibition and reinitiation of the synthesis of heterogeneous nuclear RNA in living cells

1976 • 42 citations

Identification and Analysis of a Functional Human Homolog of the SPT4 Gene of Saccharomyces cerevisiae

1996 • 38 citations

Copurification of Casein Kinase II with Transcription Factor ATF/E4TF3

1996 • 28 citations

Different biological activities of the hetero- and homodimers formed by the 47- and 43-kilodalton proteins of transcription factor ATF/E4TF3

1991 • 25 citations

Human Supt5h protein, a putative modulator of chromatin structure, is reversibly phosphorylated in mitosis

1997 • 22 citations

Isolation and Characterization of the Human and Mouse Homologues (SUPT4H andSupt4h) of the Yeast SPT4 Gene

1996 • 20 citations

Isolation, Sequencing, and Mapping of the Human Homologue of the Yeast Transcription Factor, SPT5

1996 • 18 citations

The HIP1 initiator element plays a role in determining the in vitro requirement of the dihydrofolate reductase gene promoter for the C-terminal domain of RNA polymerase II.

1992 • 16 citations