Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Mosaic Analysis with a Repressible Cell Marker for Studies of Gene Function in Neuronal Morphogenesis

1999 • 2,521 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

2000 • 861 citations

The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease

1998 • 845 citations

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

2000 • 841 citations

Presenilin is required for activity and nuclear access of Notch in Drosophila

1999 • 801 citations

Direct and Long-Range Action of a Wingless Morphogen Gradient

1996 • 736 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

1997 • 721 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1997 • 615 citations

LIN-12/Notch signaling: lessons from worms and flies

1998 • 545 citations

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

2000 • 520 citations

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1999 • 517 citations

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants

1999 • 494 citations

Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells

2000 • 480 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects

1999 • 462 citations

Requirements for Presenilin-Dependent Cleavage of Notch and Other Transmembrane Proteins

2000 • 418 citations

Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

2000 • 407 citations

The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate

1997 • 407 citations

Site-Specific Recombination Between Homologous Chromosomes in Drosophila

1991 • 389 citations

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1999 • 358 citations

Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc

1996 • 303 citations

Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis

1997 • 207 citations

Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos

1998 • 193 citations

Notch signalling pathway and human diseases

1998 • 190 citations

Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing

1997 • 178 citations

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1997 • 155 citations

Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated byNotch signaling

1998 • 154 citations

Roles of the Notch gene in Drosophila wing morphogenesis

1994 • 147 citations

Presenilins, Processing of β-Amyloid Precursor Protein, and Notch Signaling

1999 • 66 citations

Lack of requirement for Presenilin1 in Notch1 signaling

1999 • 42 citations