A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

2001 • 990 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

2000 • 861 citations

LIN-12/Notch signaling: lessons from worms and flies

1998 • 545 citations

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1999 • 517 citations

Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members

2000 • 485 citations

Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

2001 • 471 citations

The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner

2001 • 439 citations

A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor

2000 • 386 citations

Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice

2000 • 332 citations

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

1997 • 321 citations

Alzheimerʼs PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide

1996 • 321 citations

Presenilin-Mediated Modulation of Capacitative Calcium Entry

2000 • 311 citations

The Regions of the Fe65 Protein Homologous to the Phosphotyrosine Interaction/Phosphotyrosine Binding Domain of Shc Bind the Intracellular Domain of the Alzheimer's Amyloid Precursor Protein

1995 • 295 citations

The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

2001 • 232 citations

Alzheimer's Presenilin‐1 Mutation Potentiates Inositol 1,4,5‐Trisphosphate‐Mediated Calcium Signaling in Xenopus

1999 • 161 citations

Interaction of the Phosphotyrosine Interaction/Phosphotyrosine Binding-related Domains of Fe65 with Wild-type and Mutant Alzheimer's β-Amyloid Precursor Proteins

1997 • 143 citations

Presenilin-2 Mutations Modulate Amplitude and Kinetics of Inositol 1,4,5-Trisphosphate-mediated Calcium Signals

1999 • 133 citations

Mutant Presenilins Disturb Neuronal Calcium Homeostasis in the Brain of Transgenic Mice, Decreasing the Threshold for Excitotoxicity and Facilitating Long-term Potentiation

2001 • 131 citations

The Role of Presenilins in γ-Secretase Activity

2001 • 131 citations

The β-Amyloid Precursor Protein Functions as a Cytosolic Anchoring Site That Prevents Fe65 Nuclear Translocation

2001 • 129 citations

Cell‐free assays for γ‐secretase activity

2000 • 106 citations

Subcellular Mechanisms of Presenilin-Mediated Enhancement of Calcium Signaling

2001 • 56 citations