The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

1999 • 1,115 citations

A Novel Proteolytic Cleavage Involved in Notch Signaling

2000 • 1,080 citations

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

1998 • 922 citations

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1999 • 917 citations

A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1

2000 • 841 citations

Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

1999 • 797 citations

Proteolytic processing and cell biological functions of the amyloid precursor protein

2000 • 622 citations

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

1988 • 584 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture

1995 • 365 citations

Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease

1999 • 290 citations

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1997 • 289 citations

Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path

1998 • 263 citations

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.

1997 • 250 citations

Regulation of β-Amyloid Secretion by FE65, an Amyloid Protein Precursor-binding Protein

1999 • 213 citations

Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner

1995 • 196 citations

The β-Amyloid Precursor Protein of Alzheimer’s Disease Enhances Neuron Viability and Modulates Neuronal Polarity

1997 • 187 citations

The Fe65 Adaptor Protein Interacts through Its PID1 Domain with the Transcription Factor CP2/LSF/LBP1

1998 • 156 citations

Interaction of the Phosphotyrosine Interaction/Phosphotyrosine Binding-related Domains of Fe65 with Wild-type and Mutant Alzheimer's β-Amyloid Precursor Proteins

1997 • 143 citations

The Role of Presenilins in γ-Secretase Activity

2001 • 131 citations

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation

2000 • 131 citations

The β-Amyloid Precursor Protein Functions as a Cytosolic Anchoring Site That Prevents Fe65 Nuclear Translocation

2001 • 129 citations

A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases

1991 • 97 citations

hFE65L Influences Amyloid Precursor Protein Maturation and Secretion

1999 • 79 citations

Modulation of Amyloid Precursor Protein Metabolism by X11α/Mint-1

2000 • 57 citations

Subcellular Localization and Analysis of Apparent 180-kDa and 220-kDa Proteins of the Breast Cancer Susceptibility Gene, BRCA1

1996 • 51 citations

Fe65 and X11β co-localize with and compete for binding to the amyloid precursor protein

2000 • 44 citations

Expression of the Neuron-Specific FE65 Gene Marks the Development of Embryo Ganglionic Derivatives

1994 • 37 citations