The Transmembrane Heregulin Precursor Is Functionally Active

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

1993 • 744 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

MEMBRANE-ANCHORED GROWTH FACTORS

1993 • 676 citations

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.

1996 • 675 citations

Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin.

1994 • 649 citations

Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues.

1990 • 640 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1993 • 612 citations

Neu differentiation factor: A transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit

1992 • 579 citations

Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor

1992 • 552 citations

The TGF-α precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

1989 • 482 citations

All ErbB Receptors Other Than the Epidermal Growth Factor Receptor Are Endocytosis Impaired

1996 • 452 citations

Heregulin induces tyrosine phosphorylation of HER4/p180erbB4

1993 • 445 citations

Transmembrane TGF-α precursors activate EGF/TGF-α receptors

1989 • 432 citations

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

1990 • 430 citations

Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

1997 • 390 citations

Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4

1997 • 385 citations

The Cellular Response to Neuregulins Is Governed by Complex Interactions of the erbB Receptor Family

1995 • 364 citations

The erbB3 gene product is a receptor for heregulin.

1994 • 361 citations

Ligands for ErbB-family receptors encoded by a neuregulin-like gene

1997 • 288 citations

Cell-type specific interaction of Neu differentiation factor (NDF/heregulin) with Neu/HER-2 suggests complex ligand-receptor relationships.

1993 • 237 citations

Structural and Functional Aspects of the Multiplicity of Neu Differentiation Factors

1994 • 220 citations

Transformation mediated by the human HER-2 gene independent of the epidermal growth factor receptor.

1992 • 176 citations

The bride of sevenless and sevenless interaction: Internalization of a transmembrane ligand

1992 • 172 citations

Sensory and Motor Neuron-derived Factor. A NOVEL HEREGULIN VARIANT HIGHLY EXPRESSED IN SENSORY AND MOTOR NEURONS

1995 • 170 citations

The Epidermal Growth Factor Receptor Couples Transforming Growth Factor-α, Heparin-binding Epidermal Growth Factor-like Factor, and Amphiregulin to Neu, ErbB-3, and ErbB-4

1996 • 167 citations

Differential Shedding of Transmembrane Neuregulin Isoforms by the Tumor Necrosis Factor-α-Converting Enzyme

2000 • 159 citations

Direct stimulation of cells expressing receptors for macrophage colony- stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1

1990 • 150 citations

Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells

1999 • 146 citations

Growth regulation of human breast and ovarian tumor cells by heregulin: Evidence for the requirement of ErbB2 as a critical component in mediating heregulin responsiveness.

1996 • 143 citations

Neu Differentiation Factor/Neuregulin Isoforms Activate Distinct Receptor Combinations

1996 • 142 citations

Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3

1995 • 141 citations

Epidermal growth factor-related peptides in the pathogenesis of human breast cancer

1994 • 111 citations

Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.

1992 • 104 citations

Biosynthetic Processing of neu Differentiation Factor

1995 • 89 citations

Juxtacrine cell signaling molecules

1993 • 89 citations

Roles for a Cytoplasmic Tyrosine and Tyrosine Kinase Activity in the Interactions of Neu Receptors with Coated Pits

1995 • 77 citations

Cultured neonatal schwann cells contain and secrete neuregulins

1996 • 74 citations

[34] Preparation of basolateral (sinusoidal) and canalicular plasma membrane vesicles for the study of hepatic transport processes

1990 • 73 citations

ErbB-3 mediates differential mitogenic effects of NDF/heregulin isoforms on mouse keratinocytes.

1995 • 70 citations

The Neuregulin Precursor proARIA Is Processed to ARIA after Expression on the Cell Surface by a Protein Kinase C-Enhanced Mechanism

1998 • 67 citations

NDF/heregulin stimulates the phosphorylation of Her3/erbB3

1994 • 65 citations

Alteration of lipid order profile and permeability of plasma membranes from Trypanosoma cruzi epimastigotes grown in the presence of ketoconazole

1988 • 44 citations

Post-translational Processing of Membrane-associated neu Differentiation Factor Proisoforms Expressed in Mammalian Cells

1995 • 43 citations

Sensory and Motor Neuron-derived Factor Is a Transmembrane Heregulin That Is Expressed on the Plasma Membrane with the Active Domain Exposed to the Extracellular Environment

1998 • 40 citations

Expression of human epidermal growth factor precursor cDNA in transfected mouse NIH 3T3 cells.

1988 • 39 citations

Tissue and tumor expression of a cell surface glycoprotein complex containing an integral membrane glycoprotein activator of p185neu.

1994 • 24 citations

Isolation of a rat liver plasma membrane fraction of probable canalicular origin Preparative technique, enzymatic profile, composition, and solute transport

1981 • 22 citations

Isolation of cell membrane for epidermal growth factor receptor studies

1991 • 11 citations