A RIP Tide in Neuronal Signal Transduction

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Apoptosis in the nervous system

2000 • 1,850 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

1996 • 956 citations

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

2000 • 861 citations

γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase

2001 • 848 citations

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

2000 • 520 citations

Total inactivation of γ–secretase activity in presenilin-deficient embryonic stem cells

2000 • 480 citations

Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

2001 • 471 citations

The Intracellular Domain of the β-Amyloid Precursor Protein Is Stabilized by Fe65 and Translocates to the Nucleus in a Notch-like Manner

2001 • 439 citations

Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

2000 • 407 citations

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1

2000 • 323 citations

Tumor Necrosis Factor-α-converting Enzyme Is Required for Cleavage of erbB4/HER4

2000 • 310 citations

Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of Notch

2001 • 289 citations

Presenilin-dependent γ-Secretase-like Intramembrane Cleavage of ErbB4

2002 • 285 citations

The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

2001 • 232 citations

Characterization of a Presenilin-mediated Amyloid Precursor Protein Carboxyl-terminal Fragment γ

2001 • 207 citations

Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection

1995 • 153 citations

Hydrophobic Surfaces That Are Hidden in Chaperonin Cpn60 Can Be Exposed by Formation of Assembly-Competent Monomers or by Ionic Perturbation of the Oligomer

1995 • 80 citations