Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Membrane Fusion

1990 • 2,458 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

1990 • 1,423 citations

ECM and Cell Surface Proteolysis: Regulating Cellular Ecology

1997 • 1,311 citations

Notch Signaling

1995 • 1,282 citations

Processing of tumour necrosis factor-α precursor by metalloproteinases

1994 • 1,200 citations

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

1996 • 1,167 citations

A Heparin-Binding Growth Factor Secreted by Macrophage-Like Cells That Is Related to EGF

1991 • 1,135 citations

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

1999 • 1,115 citations

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

1995 • 1,035 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

1998 • 922 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease

1998 • 845 citations

Presenilin is required for activity and nuclear access of Notch in Drosophila

1999 • 801 citations

Characterization of tumor necrosis factor-deficient mice

1997 • 792 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

1993 • 729 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

1998 • 715 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

1995 • 691 citations

Downregulation of Fas ligand by shedding

1998 • 681 citations

A potential fusion peptide and an integrin ligand domain in a protein active in sperm–egg fusion

1992 • 680 citations

MEMBRANE-ANCHORED GROWTH FACTORS

1993 • 676 citations

TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

1993 • 659 citations

Membrane protein secretases

1997 • 634 citations

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1997 • 615 citations

Membrane Fusion

1992 • 613 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

1998 • 604 citations

Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

1993 • 578 citations

Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation

1994 • 573 citations

Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor

1994 • 571 citations

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

1992 • 557 citations

LIN-12/Notch signaling: lessons from worms and flies

1998 • 545 citations

A metalloprotease-disintegrin, MDC9/meltrin-gamma /ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor

1998 • 523 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

Fertilization Defects in Sperm from Mice Lacking Fertilin β

1998 • 497 citations

Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms

1990 • 497 citations

A metalloprotease-disintegrin participating in myoblast fusion

1995 • 492 citations

Molecular Cloning of a Gene Encoding a New Type of Metalloproteinase-disintegrin Family Protein with Thrombospondin Motifs as an Inflammation Associated Gene

1997 • 480 citations

Mouse egg integrin α6β1functions as a sperm receptor

1995 • 472 citations

ADAMs: focus on the protease domain

1998 • 472 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

A unique signature identifies a family of zinc‐dependent metallopeptidases

1989 • 453 citations

Shedding of tumor necrosis factor receptors by activated human neutrophils.

1990 • 443 citations

Evidence for a Role of a Tumor Necrosis Factor-α (TNF-α)-converting Enzyme-like Protease in Shedding of TRANCE, a TNF Family Member Involved in Osteoclastogenesis and Dendritic Cell Survival

1999 • 414 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors

1996 • 404 citations

Molecular Identification of the Sterol-Regulated Luminal Protease that Cleaves SREBPs and Controls Lipid Composition of Animal Cells

1998 • 400 citations

Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

1998 • 376 citations

Identification and purification of a sperm surface protein with a potential role in sperm-egg membrane fusion.

1987 • 368 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.

1992 • 346 citations

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 343 citations

KUZ, a Conserved Metalloprotease-Disintegrin Protein with Two Roles in Drosophila Neurogenesis

1996 • 331 citations

Trigramin. A low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb-IIIa complex.

1987 • 323 citations

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

1992 • 320 citations

A Novel, Secreted Form of Human ADAM 12 (Meltrin α) Provokes Myogenesis in Vivo

1998 • 315 citations

Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity

1999 • 312 citations

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

1991 • 287 citations

The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site.

1994 • 275 citations

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

1999 • 262 citations

ADAMs in Fertilization and Development

1996 • 259 citations

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor.

1995 • 254 citations

Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion.

1994 • 241 citations

A Role for the Disintegrin Domain of Cyritestin, a Sperm Surface Protein Belonging to the ADAM Family, in Mouse Sperm–Egg Plasma Membrane Adhesion and Fusion

1997 • 235 citations

Proteolytic processing of a protein involved in sperm-egg fusion correlates with acquisition of fertilization competence.

1990 • 219 citations

The Alzheimer family of diseases: Many etiologies, one pathogenesis?

1997 • 218 citations

First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.

1993 • 215 citations

Specific Interaction of the Recombinant Disintegrin-like Domain of MDC-15 (Metargidin, ADAM-15) with Integrin αvβ3

1998 • 214 citations

MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.

1996 • 213 citations

Identification and Characterization of a Pro-tumor Necrosis Factor-α-processing Enzyme from the ADAM Family of Zinc Metalloproteases

1997 • 204 citations

Calmodulin Regulates L-Selectin Adhesion Molecule Expression and Function through a Protease-Dependent Mechanism

1998 • 204 citations

Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor

1996 • 198 citations

Membrane proximal cleavage of L-selectin: identification of the cleavage site and a 6-kD transmembrane peptide fragment of L-selectin.

1994 • 198 citations

Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils.

1991 • 193 citations

Interaction of metargidin (ADAM-15) with αvβ3 and α5β1 integrins on different haemopoietic cells

1999 • 193 citations

TIMP-3 INDUCES CELL DEATH BY STABILIZING TNF-α RECEPTORS ON THE SURFACE OF HUMAN COLON CARCINOMA CELLS

1997 • 190 citations

Viper Venom Disintegrins and Related Molecules

1998 • 189 citations

Human ADAM 12 (Meltrin α) Is an Active Metalloprotease

1998 • 188 citations

The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila

1996 • 183 citations

The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications.

1993 • 182 citations

Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.

1994 • 181 citations

Why did the Sperm Cross the Cumulus? To Get to the Oocyte. Functions of the Sperm Surface Proteins PH-20 and Fertilin in Arriving at, and Fusing With, the Egg1

1997 • 171 citations

Evidence that proteolysis of the surface is an initial step in the mechanism of formation of sperm cell surface domains.

1990 • 170 citations

Metargidin, a Membrane-anchored Metalloprotease-Disintegrin Protein with an RGD Integrin Binding Sequence

1996 • 170 citations

Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes.

1995 • 168 citations

Intracellular Maturation of the Mouse Metalloprotease Disintegrin MDC15

1998 • 167 citations

Cellular Redistribution of Protein Tyrosine Phosphatases LAR and PTPσ by Inducible Proteolytic Processing

1997 • 162 citations

Trigramin: primary structure and its inhibition of von Willebrand factor binding to glycoprotein IIb/IIIa complex on human platelets

1989 • 161 citations

Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons

1996 • 158 citations

Mouse sperm-egg plasma membrane interactions: analysis of roles of egg integrins and the mouse sperm homologue of PH-30 (fertilin) β

1995 • 157 citations

SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling

1997 • 155 citations

Characterization of the Binding of Recombinant Mouse Sperm Fertilin β Subunit to Mouse Eggs: Evidence for Adhesive Activity via an Egg β1Integrin-Mediated Interaction

1997 • 153 citations

The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs

1997 • 152 citations

Identification of a truncated form of the nerve growth factor receptor.

1988 • 145 citations

Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.

1995 • 144 citations

ADAMs and cell fusion

1996 • 143 citations

Structure, function and evolutionary relationship of proteins containing a disintegrin domain

1992 • 138 citations

Mutational analysis of the membrane-proximal cleavage site of L-selectin: relaxed sequence specificity surrounding the cleavage site.

1995 • 134 citations

Purification of ADAM 10 from bovine spleen as a TNFα convertase

1997 • 133 citations

Tissue Inhibitor of Metalloproteinases-3 Inhibits Shedding of L-selectin from Leukocytes

1999 • 126 citations

Regulation of Human ADAM 12 Protease by the Prodomain

1999 • 125 citations

Molecular cloning of cDNA encoding MS2 antigen, a novel cell surface antigen strongly expressed in murine monocytic lineage

1990 • 124 citations

Cell Surface Ectodomain Cleavage of Human Amphiregulin Precursor Is Sensitive to a Metalloprotease Inhibitor

1998 • 123 citations

Role of the Juxtamembrane Domains of the Transforming Growth Factor-α Precursor and the β-Amyloid Precursor Protein in Regulated Ectodomain Shedding

1997 • 120 citations

Expression of a disintegrin‐like protein in cultured human vascular cells and in vivo

1997 • 115 citations

Evidence for Distinct Serine Protease Activities with a Potential Role in Processing the Sperm Protein Fertilin

1997 • 113 citations

ADAM 13: A Novel ADAM Expressed in Somitic Mesoderm and Neural Crest Cells duringXenopus laevisDevelopment

1997 • 109 citations

Cloning and Initial Characterization of Mouse Meltrin β and Analysis of the Expression of Four MetalloproteaseDisintegrins in Bone Cells

1998 • 109 citations

Mediation of sperm-egg fusion: evidence that mouse egg α6β1 integrin is the receptor for sperm fertilinβ

1999 • 108 citations

Complex Proteolytic Processing Acts on Delta, a Transmembrane Ligand for Notch, duringDrosophilaDevelopment

1998 • 103 citations

Spatially- and temporally-restricted expression of meltrin α (ADAM12) and β (ADAM19) in mouse embryo

1998 • 102 citations

A novel metalloprotease/disintegrin–like gene at 17q21.3 is somatically rearranged in two primary breast cancers

1993 • 97 citations

A family of cellular proteins related to snake venom disintegrins.

1994 • 96 citations

A mammalian epididymal protein with remarkable sequence similarity to snake venom haemorrhagic peptides

1992 • 96 citations

Evidence that Distinct States of the Integrin α6β1 Interact with Laminin and an ADAM

1999 • 96 citations

Isolation of Cholesterol-requiring Mutant Chinese Hamster Ovary Cells with Defects in Cleavage of Sterol Regulatory Element-binding Proteins at Site 1

1998 • 95 citations

Sequential Cleavage and Excision of a Segment of the Thyrotropin Receptor Ectodomain

1999 • 94 citations

Human myeloma cells shed the interleukin‐6 receptor: inhibition by tissue inhibitor of metalloproteinase‐3 and a hydroxamate‐based metalloproteinase inhibitor

1998 • 94 citations

Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans

1998 • 94 citations

Roles for Proteolysis and Trafficking in Notch Maturation and Signal Transduction

1998 • 92 citations

Apical Enrichment of Human EGF Precursor in Madin-Darby Canine Kidney Cells Involves Preferential Basolateral Ectodomain Cleavage Sensitive to a Metalloprotease Inhibitor

1997 • 90 citations

Sperm disintegrins, egg integrins, and other cell adhesion molecules of mammalian gamete plasma membrane interactions

1999 • 88 citations

Pro-Tumor Necrosis Factor-α Processing Activity Is Tightly Controlled by a Component That Does Not Affect Notch Processing

1998 • 88 citations

Tyrosine Phosphorylation and Proteolysis

1998 • 87 citations

Polymerase Chain Reaction Selects a Novel Disintegrin Proteinase from CD40-Activated Germinal Center Dendritic Cells

1997 • 86 citations

Neuronal cell fate specification in Drosophila

1994 • 86 citations

Posttranslational Regulation of a Leishmania HEXXH Metalloprotease (gp63)

1996 • 82 citations

Characterization of the Binding of Recombinant Mouse Sperm Fertilin α Subunit to Mouse Eggs: Evidence for Function as a Cell Adhesion Molecule in Sperm-Egg Binding

1997 • 70 citations

Roles of the Disintegrin Domains of Mouse Fertilins α and β in Fertilization1

1998 • 70 citations

Relaxed Specificity of Matrix Metalloproteinases (MMPS) and TIMP Insensitivity of Tumor Necrosis Factor-α (TNF-α) Production Suggest the Major TNF-α Converting Enzyme Is Not an MMP

1996 • 69 citations

Identification of Metalloprotease/Disintegrins inXenopus laevisTestis with a Potential Role in Fertilization

1997 • 69 citations

Mutational analysis of proprotein processing, subunit association, and shedding of the LAR transmembrane protein tyrosine phosphatase.

1994 • 68 citations

Human Metalloprotease-Disintegrin Kuzbanian Regulates Sympathoadrenal Cell Fate in Development and Neoplasia

1998 • 64 citations

Metalloproteinase super–families and drug design

1994 • 62 citations

Decreased in vitro fertilization efficiencies in the presence of specific cyritestin peptides

1997 • 54 citations

Advances in developmental biochemistry

1992 • 53 citations

Male Germ Cell‐Expressed Mouse Gene TAZ83 Encodes a Putative, Cysteine‐rich Transmembrane Protein (cyritestin) Sharing Homologies with Snake Toxins and Sperm‐Egg Fusion Proteins

1994 • 52 citations

Unaltered Cleavage and Secretion of Angiotensin-converting Enzyme in Tumor Necrosis Factor-α-converting Enzyme-deficient Mice

1999 • 49 citations

Blastocyst-dependent upregulation of metalloproteinase/disintegrin MDC9 expression in rabbit endometrium

1998 • 46 citations

Cleavage Processing of Angiotensin-Converting Enzyme by a Membrane-Associated Metalloprotease

1995 • 45 citations

Neural Crest-Specific and General Expression of Distinct Metalloprotease–Disintegrins in EarlyXenopus laevisDevelopment

1998 • 38 citations

Proteolytic processing of a plasma membrane-bound precursor to human macrophage colony-stimulating factor (CSF-1) is accelerated by phorbol ester.

1991 • 38 citations

Roles of Metalloprotease-Disintegrins in Cell-Cell Interactions, in Neurogenesis, and in the Cleavage of TNFα

1999 • 5 citations

Deleted Work

1955 • 0 citations