Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Beta-amyloid precursor protein cleavage by a membrane-bound protease.

1992 • 726 citations

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

1992 • 557 citations

ADAM, a novel family of membrane proteins containing A Disintegrin And Metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.

1995 • 507 citations

Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors

1996 • 404 citations

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein.

1993 • 401 citations

Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

1998 • 376 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 343 citations

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.

1993 • 279 citations

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.

1989 • 251 citations

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.

1993 • 236 citations

Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion

1996 • 221 citations

The Alzheimer family of diseases: Many etiologies, one pathogenesis?

1997 • 218 citations

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

1991 • 210 citations

Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.

1994 • 181 citations

Regulated Formation of Golgi Secretory Vesicles Containing Alzheimer β-Amyloid Precursor Protein

1995 • 165 citations

Inhibition of β‐Amyloid Production by Activation of Protein Kinase C

1993 • 144 citations

Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.

1995 • 144 citations

Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein.

1994 • 143 citations

Regulation of Amyloid Precursor Protein Catabolism Involves the Mitogen-Activated Protein Kinase Signal Transduction Pathway

1997 • 133 citations

Secretory processing of the Alzheimer amyloid βA4 protein precursor is increased by protein phosphorylation

1992 • 109 citations

Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the Mitogen‐Activated Protein Kinase Cascade

1998 • 109 citations

Role of neurotransmission in the regulation of amyloid β-protein precursor processing

1994 • 101 citations

“Secretase,” Alzheimer amyloid protein precursor secreting enzyme is not sequence-specific

1991 • 98 citations

Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.

1996 • 82 citations

Muscarinic m1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain

1997 • 79 citations

Regulated cleavage of alzheimer β-amyloid precursor protein in the absence of the cytoplasmic tail

1993 • 70 citations

Relaxed Specificity of Matrix Metalloproteinases (MMPS) and TIMP Insensitivity of Tumor Necrosis Factor-α (TNF-α) Production Suggest the Major TNF-α Converting Enzyme Is Not an MMP

1996 • 69 citations

Expression of APP in Brains of Transgenic Mice Containing the Entire Human APP Gene

1993 • 64 citations

The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2.

1991 • 51 citations

Amyloid β Peptide Formation in Cell-free Preparations

1996 • 49 citations

Increased Secretion of the Amino‐Terminal Fragment of Amyloid Precursor Protein in Brains of Rats with a Constitutive Up‐Regulation of Protein Kinase C

1997 • 48 citations

Receptor‐coupled Amyloid Precursor Protein Processing^a

1993 • 40 citations