Mutational analysis of proprotein processing, subunit association, and shedding of the LAR transmembrane protein tyrosine phosphatase.

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

Current Protocols in Molecular Biology

1989 • 1,916 citations

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

1993 • 1,531 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes

1991 • 973 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

1994 • 747 citations

The Leukocyte Common Antigen Family

1989 • 741 citations

Ordered rearrangement of immunoglobulin heavy chain variable region segments.

1984 • 736 citations

Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.

1992 • 688 citations

MEMBRANE-ANCHORED GROWTH FACTORS

1993 • 676 citations

The new enzymology of precursor processing endoproteases.

1992 • 608 citations

Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus

1988 • 608 citations

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1992 • 593 citations

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1991 • 590 citations

Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation

1993 • 554 citations

PROTEIN TYROSINE PHOSPHATASES

1993 • 532 citations

Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice

1993 • 509 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.

1991 • 468 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.

1989 • 465 citations

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

1992 • 455 citations

Shedding of tumor necrosis factor receptors by activated human neutrophils.

1990 • 443 citations

Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.

1990 • 428 citations

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

1992 • 400 citations

Reproducible high yield sequencing of proteins electrophoretically separated and transferred to an inert support.

1988 • 375 citations

Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR.

1990 • 365 citations

Hematopoietic Cell Phosphatase Associates with the Interleukin-3 (IL-3) Receptor β Chain and Down-Regulates IL-3-Induced Tyrosine Phosphorylation and Mitogenesis

1993 • 340 citations

Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

1994 • 331 citations

A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.

1989 • 303 citations

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

1991 • 287 citations

A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.

1988 • 277 citations

Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation

1993 • 268 citations

Insulin-Resistant Diabetes Due to a Point Mutation That Prevents Insulin Proreceptor Processing

1988 • 253 citations

Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms.

1989 • 228 citations

The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system

1993 • 227 citations

Cell-cell adhesion mediated by a receptor-like protein tyrosine phosphatase

1993 • 227 citations

Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding.

1994 • 224 citations

A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases.

1992 • 216 citations

Structure of pre-pro-von Willebrand factor and its expression in heterologous cells

1986 • 212 citations

Three receptor-linked protein-tyrosine phosphatases are selectively expressed on central nervous system axons in the Drosophila embryo

1991 • 212 citations

Expression of the receptor-linked protein tyrosine phosphatase LAR: proteolytic cleavage and shedding of the CAM-like extracellular region.

1992 • 166 citations

Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of the polypeptides and relation to the Ig superfamily.

1991 • 160 citations

Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.

1993 • 156 citations

Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNA.

1989 • 151 citations

CD45. A prototype for transmembrane protein tyrosine phosphatases.

1991 • 142 citations

Cloning, expression and chromosomal localization of a new putative receptor‐like protein tyrosine phosphatase

1991 • 134 citations

Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase.

1991 • 132 citations

Mutational analysis of the human immunodeficiency virus type 1 env gene product proteolytic cleavage site

1990 • 131 citations

Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes

1992 • 130 citations

Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis.

1993 • 128 citations

Sequence requirements for precursor cleavage within the constitutive secretory pathway.

1992 • 113 citations

Isolation and structural elucidation of a novel phosphocysteine intermediate in the LAR protein tyrosine phosphatase enzymic pathway

1992 • 103 citations

Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells.

1991 • 102 citations

A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system.

1993 • 97 citations

Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium

1992 • 81 citations

Reversible tyrosine phosphorylation and cell cycle control

1993 • 76 citations

Great expectations: protein tyrosine phosphatases in cell regulation

1992 • 75 citations

Specific CD45 isoforms differentially regulate T cell receptor signaling.

1994 • 74 citations

MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineage.

1993 • 70 citations

Structure and activity of the sevenless protein: a protein tyrosine kinase receptor required for photoreceptor development in Drosophila.

1989 • 69 citations

Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells.

1990 • 62 citations

The N-terminal and C-terminal domains of a receptor tyrosine phosphatase are associated by non-covalent linkage.

1992 • 61 citations

Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site

1988 • 46 citations

Rapid site-specific mutagenesis in plasmids

1987 • 44 citations

Cloning and expression of two structurally distinct receptor-linked protein-tyrosine phosphatases generated by RNA processing from a single gene.

1993 • 44 citations

Okadaic acid induces down-modulation and shedding of tumor necrosis factor receptors. Comparison with another tumor promoter, phorbol ester.

1993 • 33 citations

Structural diversity of eukaryotic protein tyrosine phosphatases: functional and evolutionary implications

1993 • 32 citations

Characterization of an insulin receptor mutant lacking the subunit processing site.

1990 • 31 citations

Introduction: Protein tyrosine phosphatases

1993 • 30 citations