Crystal structure of the catalytic domain of human tumor necrosis factor-α-converting enzyme

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Treatment of Rheumatoid Arthritis with a Recombinant Human Tumor Necrosis Factor Receptor (p75)–Fc Fusion Protein

1997 • 1,651 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc‐binding environments (HEXXHXXGXXH and Met‐turn) and topologies and should be grouped into a common family, the ‘metzincins’

1993 • 729 citations

The metzincins — Topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc‐peptidases

1995 • 691 citations

Membrane protein secretases

1997 • 634 citations

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

1997 • 610 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

Structure of tumour necrosis factor

1989 • 512 citations

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

1990 • 409 citations

Tumor Necrosis Factor: Function, Release and Clearance

1996 • 274 citations

ADAMs in Fertilization and Development

1996 • 259 citations

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

1995 • 234 citations

First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases.

1993 • 215 citations

Identification and Characterization of a Pro-tumor Necrosis Factor-α-processing Enzyme from the ADAM Family of Zinc Metalloproteases

1997 • 204 citations

X-ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors. Implications for Substrate Binding and Rational Drug Design

1995 • 170 citations

Human pro-Tumor Necrosis Factor Is a Homotrimer

1996 • 150 citations

Refined 2·0 Å X-ray Crystal Structure of the Snake Venom Zinc-endopeptidase Adamalysin II

1994 • 142 citations

Purification of ADAM 10 from bovine spleen as a TNFα convertase

1997 • 133 citations

Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d).

1994 • 130 citations

Relaxed Specificity of Matrix Metalloproteinases (MMPS) and TIMP Insensitivity of Tumor Necrosis Factor-α (TNF-α) Production Suggest the Major TNF-α Converting Enzyme Is Not an MMP

1996 • 69 citations

Crystal Structure of H2-Proteinase from the Venom of Trimeresurus flavoviridis

1996 • 67 citations

Anti-arthritic activity of hydroxamic acid-based pseudopeptide inhibitors of matrix metalloproteinases and TNFα processing

1997 • 44 citations

Length of the Linking Domain of Human pro-Tumor Necrosis Factor Determines the Cleavage Processing

1996 • 41 citations

Crystallographic phasing and refinement of macromolecules

1991 • 23 citations