Cell Surface-bound Collagenase-1 and Focal Substrate Degradation Stimulate the Rear Release of Motile Vascular Smooth Muscle Cells

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness

1997 • 1,400 citations

Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF

1991 • 1,081 citations

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

1997 • 958 citations

Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor.

1991 • 722 citations

Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion

1999 • 699 citations

Evidence for Increased Collagenolysis by Interstitial Collagenases-1 and -3 in Vulnerable Human Atheromatous Plaques

1999 • 660 citations

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.

1998 • 646 citations

The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases

1998 • 631 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

The Activity of Collagenase-1 Is Required for Keratinocyte Migration on a Type I Collagen Matrix

1997 • 600 citations

Ca2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils

1995 • 555 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen.

1989 • 422 citations

Interstitial Collagenase (MMP-1) Expression in Human Carotid Atherosclerosis

1995 • 402 citations

Inhibition of Matrix Metalloproteinase Activity Inhibits Smooth Muscle Cell Migration but Not Neointimal Thickening After Arterial Injury

1996 • 307 citations

Mechanism of retraction of the trailing edge during fibroblast movement.

1981 • 290 citations

A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling.

1995 • 280 citations

The behavior of fibroblasts from the developing avian cornea. Morphology and movement in situ and in vitro.

1975 • 265 citations

Degraded Collagen Fragments Promote Rapid Disassembly of Smooth Muscle Focal Adhesions That Correlates with Cleavage of Pp125FAK, Paxillin, and Talin

1999 • 249 citations

Dynamics of beta 1 integrin-mediated adhesive contacts in motile fibroblasts.

1992 • 222 citations

Integrin dynamics on the tail region of migrating fibroblasts

1996 • 175 citations

Collagens in Atherosclerosis

1985 • 165 citations

In Vivo Collagen Turnover Following Experimental Balloon Angioplasty Injury and the Role of Matrix Metalloproteinases

1996 • 165 citations

Basic fibroblast growth factor: its role in the control of smooth muscle cell migration.

1993 • 139 citations

Evidence for a role of collagen synthesis in arterial smooth muscle cell migration.

1998 • 134 citations

Evidence From a Novel Human Cell Clone That Adult Vascular Smooth Muscle Cells Can Convert Reversibly Between Noncontractile and Contractile Phenotypes

1999 • 132 citations

Adenovirus-Mediated Gene Transfer of the Human Tissue Inhibitor of Metalloproteinase-2 Blocks Vascular Smooth Muscle Cell Invasiveness In Vitro and Modulates Neointimal Development In Vivo

1998 • 122 citations

Integrin-Mediated Collagen Matrix Reorganization by Cultured Human Vascular Smooth Muscle Cells

1995 • 122 citations

Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.

1994 • 109 citations

Effects of collagenase-cleavage of type I collagen on α2β1 integrin-mediated cell adhesion

1998 • 96 citations

Monoclonal antibodies to human fibroblast procollagenase. Inhibition of enzymatic activity, affinity purification of the enzyme, and evidence for clustering of epitopes in the amino-terminal end of the activated enzyme

1988 • 91 citations

The Involvement of the Fibronectin Type II-like Modules of Human Gelatinase A in Cell Surface Localization and Activation

1998 • 89 citations

Coordinated Effects of Fibroblast Growth Factor-2 on Expression of Fibrillar Collagens, Matrix Metalloproteinases, and Tissue Inhibitors of Matrix Metalloproteinases by Human Vascular Smooth Muscle Cells

1997 • 87 citations

Intracellular signaling pathways required for rat vascular smooth muscle cell migration. Interactions between basic fibroblast growth factor and platelet-derived growth factor.

1995 • 86 citations

Fibroblast Growth Factor-2 Potentiates Vascular Smooth Muscle Cell Migration to Platelet-Derived Growth Factor

1997 • 75 citations

Smooth muscle cell outgrowth from human atherosclerotic plaque: Implications for the assessment of lesion biology

1992 • 75 citations

Expression of collagen, interstitial collagenase, and tissue inhibitor of metalloproteinases-1 in restenosis after carotid endarterectomy.

1996 • 66 citations

Evidence for Rapid Accumulation and Persistently Disordered Architecture of Fibrillar Collagen in Human Coronary Restenosis Lesions * *This study was supported by a grant from the Medical Research Council of Canada (MT-11715)

1996 • 57 citations

Prevention of smooth muscle cell outgrowth from human atherosclerotic plaque by a recombinant cytotoxin specific for the epidermal growth factor receptor.

1993 • 46 citations