MMP-9 Sheds the β2 Integrin Subunit (CD18) from Macrophages

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

DAVID: Database for Annotation, Visualization, and Integrated Discovery

2003 • 8,668 citations

Empirical Statistical Model To Estimate the Accuracy of Peptide Identifications Made by MS/MS and Database Search

2002 • 4,851 citations

A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry

2003 • 4,657 citations

BiNGO: a Cytoscape plugin to assess overrepresentation of Gene Ontology categories in Biological Networks

2005 • 4,037 citations

Getting to the site of inflammation: the leukocyte adhesion cascade updated

2007 • 3,957 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics

2004 • 2,430 citations

Matrix metalloproteinases as modulators of inflammation and innate immunity

2004 • 1,833 citations

Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.

2002 • 1,781 citations

Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

2002 • 1,755 citations

Mass spectrometry–based proteomics turns quantitative

2005 • 1,548 citations

Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis

2002 • 1,460 citations

Comparison of Label-free Methods for Quantifying Human Proteins by Shotgun Proteomics

2005 • 1,199 citations

Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation

2006 • 1,127 citations

Regulation of matrix biology by matrix metalloproteinases

2004 • 1,080 citations

Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL

2007 • 913 citations

Stability and Instability: Two Faces of Coronary Atherosclerosis

1996 • 910 citations

Role of the Matrix Metalloproteinase and Plasminogen Activator–Plasmin Systems in Angiogenesis

2001 • 754 citations

Retinoic Acid Early Inducible Genes Define a Ligand Family for the Activating NKG2D Receptor in Mice

2000 • 694 citations

Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact

2000 • 653 citations

Nuclear Membrane Proteins with Potential Disease Links Found by Subtractive Proteomics

2003 • 647 citations

Quantification of Proteins and Metabolites by Mass Spectrometry without Isotopic Labeling or Spiked Standards

2003 • 641 citations

Proteolytic processing and cell biological functions of the amyloid precursor protein

2000 • 622 citations

Activation, coactivation, and costimulation of resting human natural killer cells

2006 • 594 citations

Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo

2002 • 594 citations

Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.

1996 • 496 citations

Molecular Determinants of Metalloproteinase Substrate Specificity: Matrix Metalloproteinase Substrate Binding Domains, Modules, and Exosites

2002 • 493 citations

Shedding light on ADAM metalloproteinases

2005 • 449 citations

Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice

2005 • 436 citations

ADAMs family members as amyloid precursor protein α‐secretases

2003 • 430 citations

Quantitative Profiling of Proteins in Complex Mixtures Using Liquid Chromatography and Mass Spectrometry

2002 • 424 citations

Matrix metalloproteinases and TIMPs

2000 • 379 citations

Degradation of Interleukin 1β by Matrix Metalloproteinases

1996 • 374 citations

The Role of the C-terminal Domain of Human Collagenase-3 (MMP-13) in the Activation of Procollagenase-3, Substrate Specificity, and Tissue Inhibitor of Metalloproteinase Interaction

1997 • 345 citations

Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).

1996 • 341 citations

In search of partners: linking extracellular proteases to substrates

2007 • 340 citations

Matrix Metalloproteinase-9 Degrades Amyloid-β Fibrils in Vitro and Compact Plaques in Situ

2006 • 339 citations

Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism

2006 • 331 citations

Role of Matrix Metalloproteinases in Abdominal Aortic Aneurysmsa

1996 • 304 citations

Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40)

1996 • 293 citations

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1–matrix metalloproteinase substrates

2004 • 271 citations

A novel role of metalloproteinase in cancer-mediated immunosuppression.

2001 • 267 citations

Neutrophil β2 integrins: moderators of life or death decisions

2005 • 243 citations

Basement Membrane and Repair of Injury to Peripheral Nerve: Defining a Potential Role for Macrophages, Matrix Metalloproteinases, and Tissue Inhibitor of Metalloproteinases-1

1996 • 242 citations

Proteomics Discovery of Metalloproteinase Substrates in the Cellular Context by iTRAQ™ Labeling Reveals a Diverse MMP-2 Substrate Degradome

2007 • 231 citations

Improving Reproducibility and Sensitivity in Identifying Human Proteins by Shotgun Proteomics

2004 • 229 citations

Emerging roles for ectodomain shedding in the regulation of inflammatory responses

2006 • 220 citations

Leukocyte CD11/CD18 integrins: biological and clinical relevance.

1995 • 215 citations

Degradomics: Systems biology of the protease web. Pleiotropic roles of MMPs in cancer

2006 • 214 citations

Cutting Edge: Toll-Like Receptor Signaling in Macrophages Induces Ligands for the NKG2D Receptor

2004 • 203 citations

Identification and Characterization of Human Endometase (Matrix Metalloproteinase-26) from Endometrial Tumor

2000 • 197 citations

Proteomic Identification of In Vivo Substrates for Matrix Metalloproteinases 2 and 9 Reveals a Mechanism for Resolution of Inflammation

2006 • 177 citations

Novel mechanistic concepts for the control of leukocyte transmigration: specialization of integrins, chemokines, and junctional molecules

2003 • 176 citations

The shedding of syndecan-4 and syndecan-1 from HeLa cells and human primary macrophages is accelerated by SDF-1/CXCL12 and mediated by the matrix metalloproteinase-9

2006 • 170 citations

Regulated Secretion from Hemopoietic Cells

1999 • 166 citations

Cell-surface association between matrix metalloproteinases and integrins: role of the complexes in leukocyte migration and cancer progression

2006 • 165 citations

Novel MMP-9 Substrates in Cancer Cells Revealed by a Label-free Quantitative Proteomics Approach

2008 • 161 citations

Discovery of Chemokine Substrates for Matrix Metalloproteinases by Exosite Scanning: A New Tool for Degradomics

2002 • 134 citations

Ubiquicidin, a novel murine microbicidal protein present in the cytosolic fraction of macrophages

1999 • 133 citations

Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem

1996 • 130 citations

Combined Statin and Niacin Therapy Remodels the High-Density Lipoprotein Proteome

2008 • 126 citations

Matrix Metalloproteinases and TlMPs

2000 • 125 citations

Reproducibility of Quantitative Proteomic Analyses of Complex Biological Mixtures by Multidimensional Protein Identification Technology

2003 • 124 citations

Proteomic Identification of Desmoglein 2 and Activated Leukocyte Cell Adhesion Molecule as Substrates of ADAM17 and ADAM10 by Difference Gel Electrophoresis

2006 • 114 citations

Inducible Expression of Tissue Inhibitor of Metalloproteinases–Resistant Matrix Metalloproteinase-9 on the Cell Surface of Neutrophils

2003 • 111 citations

A Closer Look at α-Secretase

2008 • 108 citations

Spectral Index for Assessment of Differential Protein Expression in Shotgun Proteomics

2008 • 102 citations

New Insights into Plaque Stabilisation by Lipid Lowering

1998 • 102 citations

A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma

2004 • 94 citations

A Proteomic Approach for the Identification of Cell-surface Proteins Shed by Metalloproteases

2002 • 94 citations

Similarities and differences between asthma and chronic obstructive pulmonary disease: treatment and early outcomes

2003 • 93 citations

Galectin-3 Is a Downstream Regulator of Matrix Metalloproteinase-9 Function during Endochondral Bone Formation

2005 • 93 citations

A novel antimicrobial function for a ribosomal peptide from rainbow trout skin

2002 • 90 citations

Affinity, Kinetics, and Thermodynamics of E-selectin Binding to E-selectin Ligand-1

2001 • 88 citations

EWI-2 regulates α3β1 integrin–dependent cell functions on laminin-5

2003 • 83 citations

Differential modulation of plasma β-amyloid by insulin in patients with Alzheimer disease

2006 • 83 citations

Proteolysis in the lung

2003 • 81 citations

Shedding of lymphocyte function–associated antigen-1 (LFA-1) in a human inflammatory response

2006 • 70 citations

Matrilysin in Epithelial Repair and Defense

2001 • 65 citations

Intracellular and Cell Surface Localization of a Complex between αMβ2 Integrin and Promatrix Metalloproteinase-9 Progelatinase in Neutrophils

2004 • 61 citations

In‐vitro matured human macrophages express Alzheimer's βA4‐amyloid precursor protein indicating synthesis in microglial cells

1991 • 57 citations

Amyloid Precursor Protein Mediates Proinflammatory Activation of Monocytic Lineage Cells

2004 • 54 citations

Efficient Expression of Exogenous Genes in Primary Vascular Cells Using IRES-Based Retroviral Vectors

2002 • 52 citations

Characterization of Mouse Spleen Cells by Subtractive Proteomics

2005 • 48 citations

Abeta(1–40)-induced secretion of matrix metalloproteinase-9 results in sAPPα release by association with cell surface APP

2007 • 46 citations

Normal and abnormal secretion by haemopoietic cells

2001 • 31 citations

Homing alone? CD18 in infectious and allergic disease

2004 • 25 citations

Immune lysis of hepatocytes in culture: Accurate detection by aspartate aminotransferase release measurement

1984 • 22 citations

Engineering Autoactivating Forms of Matrix Metalloproteinase-9 and Expression of the Active Enzyme in Cultured Cells and Transgenic Mouse Brain

2002 • 20 citations

Comparison of Parameters of Poisson Distributions

1962 • 6 citations