Collective cell migration in morphogenesis, regeneration and cancer

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

Tumour-cell invasion and migration: diversity and escape mechanisms

2003 • 3,069 citations

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia

2003 • 2,765 citations

The epithelial–mesenchymal transition: new insights in signaling, development, and disease

2006 • 1,987 citations

Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

2007 • 1,673 citations

Filopodia: molecular architecture and cellular functions

2008 • 1,628 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

2007 • 1,446 citations

Three-dimensional culture models of normal and malignant breast epithelial cells

2007 • 1,256 citations

Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion

2000 • 1,167 citations

Keratinocyte–Fibroblast Interactions in Wound Healing

2007 • 1,165 citations

Functional atlas of the integrin adhesome

2007 • 1,127 citations

MicroRNAs: new regulators of immune cell development and function

2008 • 1,065 citations

Reassessing Epithelial to Mesenchymal Transition as a Prerequisite for Carcinoma Invasion and Metastasis

2006 • 1,041 citations

Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation

2004 • 978 citations

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

2007 • 970 citations

The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

1999 • 916 citations

Collective migration of an epithelial monolayer in response to a model wound

2007 • 882 citations

Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation.

1974 • 775 citations

Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries

2007 • 684 citations

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis

2003 • 679 citations

Tight Junctions/Adherens Junctions: Basic Structure and Function

2007 • 661 citations

Prespecification and plasticity: shifting mechanisms of cell migration

2004 • 658 citations

branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching

1996 • 631 citations

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

2008 • 589 citations

Control of Chemokine-Guided Cell Migration by Ligand Sequestration

2008 • 589 citations

Contact inhibition of locomotion in vivo controls neural crest directional migration

2008 • 571 citations

Interstitial leukocyte migration and immune function

2008 • 536 citations

Chemokine Signaling Mediates Self-Organizing Tissue Migration in the Zebrafish Lateral Line

2006 • 497 citations

Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

2002 • 486 citations

Guidance of Cell Migration by the Drosophila PDGF/VEGF Receptor

2001 • 465 citations

Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell–cell adhesion

2007 • 458 citations

Tensional forces in fibrillar extracellular matrices control directional capillary sprouting

1999 • 446 citations

Collective cell migration in morphogenesis and cancer

2004 • 432 citations

Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement

2004 • 414 citations

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

2008 • 396 citations

Actin Cable Dynamics and Rho/Rock Orchestrate a Polarized Cytoskeletal Architecture in the Early Steps of Assembling a Stratified Epithelium

2002 • 334 citations

The lateral line microcosmos

2007 • 332 citations

DE-Cadherin Is Required for Intercellular Motility during Drosophila Oogenesis

1999 • 330 citations

slow border cells, a locus required for a developmentally regulated cell migration during oogenesis, encodes Drosophila CEBP

1992 • 326 citations

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

2008 • 324 citations

Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies.

2002 • 314 citations

Molecular basis of cell migration in the fish lateral line: Role of the chemokine receptor CXCR4 and of its ligand, SDF1

2002 • 306 citations

The Chemokine SDF1a Coordinates Tissue Migration through the Spatially Restricted Activation of Cxcr7 and Cxcr4b

2007 • 302 citations

Two distinct modes of guidance signalling during collective migration of border cells

2007 • 293 citations

Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1

2007 • 290 citations

VEGF and endothelial guidance in angiogenic sprouting

2008 • 287 citations

Morphogenetic Cell Movements: Diversity from Modular Mechanical Properties

2008 • 274 citations

Apoptotic Force and Tissue Dynamics During Drosophila Embryogenesis

2008 • 272 citations

Modular control of endothelial sheet migration

2008 • 271 citations

A crucial role of β1 integrins for keratinocyte migration in vitro and during cutaneous wound repair

2002 • 266 citations

Proteolytic interstitial cell migration: a five-step process

2009 • 264 citations

Tube or Not Tube

2003 • 264 citations

Dynamics of Basement Membrane Formation by Keratinocyte–Fibroblast Interactions in Organotypic Skin Culture

1998 • 256 citations

Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1

2008 • 247 citations

Migration of coordinated cell clusters in mesenchymal and epithelial cancer explants in vitro.

1995 • 239 citations

Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model

2008 • 239 citations

Wnt/β-Catenin and Fgf Signaling Control Collective Cell Migration by Restricting Chemokine Receptor Expression

2008 • 233 citations

Cell‐autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis

2005 • 226 citations

Myosin VI is required for E-cadherin-mediated border cell migration

2002 • 224 citations

Social interactions among epithelial cells during tracheal branching morphogenesis

2006 • 223 citations

Molecular plasticity of human melanoma cells

2003 • 222 citations

In vivo evidence for short- and long-range cell communication in cranial neural crest cells

2004 • 220 citations

Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis.

1996 • 216 citations

Dynamic Fgf signaling couples morphogenesis and migration in the zebrafish lateral line primordium

2008 • 210 citations

Activated Leukocyte Cell Adhesion Molecule/CD166, a Marker of Tumor Progression in Primary Malignant Melanoma of the Skin

2000 • 208 citations

Basal-to-apical cadherin flow at cell junctions

2006 • 203 citations

Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

2009 • 196 citations

Local Cortical Tension by Myosin II Guides 3D Endothelial Cell Branching

2009 • 190 citations

Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression

2000 • 189 citations

Drosophila nonmuscle myosin II has multiple essential roles in imaginal disc and egg chamber morphogenesis

1996 • 189 citations

EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution

2007 • 186 citations

NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin

2008 • 186 citations

Patterning Mechanisms of Branched Organs

2008 • 185 citations

Role of the SIKVAV Site of Laminin in Promotion of Angiogenesis and Tumor Growth: An In Vivo Matrigel Model

1992 • 185 citations

Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells

2007 • 178 citations

Desmosomes: a role in cancer?

2007 • 178 citations

FGF-Dependent Mechanosensory Organ Patterning in Zebrafish

2008 • 175 citations

β1 Integrins Control the Formation of Cell Chains in the Adult Rostral Migratory Stream

2007 • 159 citations

In Vivo Imaging Reveals Different Cellular Functions for FGF and Dpp Signaling in Tracheal Branching Morphogenesis

2002 • 156 citations

Up-Regulated Expression of Zonula Occludens Protein-1 in Human Melanoma Associates with N-Cadherin and Contributes to Invasion and Adhesion

2005 • 156 citations

Role of boundary conditions in an experimental model of epithelial wound healing

2006 • 151 citations

Invasive cell migration is initiated by guided growth of long cellular extensions

2002 • 149 citations

Movements of Epithelial Cell Sheets In Vitro

1966 • 148 citations

Tip-Cell Migration Controls Stalk-Cell Intercalation during Drosophila Tracheal Tube Elongation

2008 • 142 citations

Tracheal branching morphogenesis inDrosophila: new insights into cell behaviour and organ architecture

2008 • 141 citations

Mouse aortic ring assay: A new approach of the molecular genetics of angiogenesis

2002 • 138 citations

Proteolytic and non-proteolytic migration of tumour cells and leucocytes

2003 • 136 citations

Front-cell-specific expression of membrane-type 1 matrix metalloproteinase and gelatinase A during cohort migration of colon carcinoma cells induced by hepatocyte growth factor/scatter factor.

2000 • 133 citations

Distinct Roles of Vascular Endothelial Growth Factor-D in Lymphangiogenesis and Metastasis

2007 • 128 citations

Collective guidance of collective cell migration

2007 • 126 citations

Dictyostelium morphogenesis

2004 • 123 citations

Organizing moving groups during morphogenesis

2005 • 116 citations

JNK Signaling Controls Border Cell Cluster Integrity and Collective Cell Migration

2008 • 110 citations

Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion

2005 • 109 citations

Tight junction-related structures in the absence of a lumen: Occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas

2003 • 109 citations

Propagating chemoattractant waves coordinate periodic cell movement inDictyosteliumslugs

2001 • 102 citations

Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge

2008 • 99 citations

Cohort migration of carcinoma cells: differentiated colorectal carcinoma cells move as coherent cell clusters or sheets.

1999 • 98 citations

p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin

2007 • 92 citations

Regulation of Cell Adhesion and Collective Cell Migration by Hindsight and Its Human Homolog RREB1

2008 • 87 citations

Wound Healing Is Defective in Mice Lacking Tetraspanin CD151

2006 • 86 citations

L1-CAM in cancerous tissues

2008 • 86 citations

Visualizing PI3 Kinase-Mediated Cell-Cell Signaling during Dictyostelium Development

2002 • 84 citations

Desmocollin switching in colorectal cancer

2006 • 79 citations

The Notch pathway helps to pattern the tips of the Drosophila tracheal branches by selecting cell fates

1999 • 75 citations

Regulation of HGF and SDF-1 expression by oral fibroblasts – Implications for invasion of oral cancer

2007 • 75 citations

The movement of cell clusters in vitro. morphology and directionality

1981 • 75 citations

Comparative Mechanisms of Branching Morphogenesis in Diverse Systems

2006 • 75 citations

Formation and activation of fibroblast spheroids depend on fibronectin–integrin interaction

2008 • 74 citations

Increased expression of connexin 26 in the invasive component of lung squamous cell carcinoma: Significant correlation with poor prognosis

2005 • 73 citations

EMT and MET in carcinoma—clinical observations, regulatory pathways and new models

2008 • 66 citations

The stage-specific function of gap junctions during tumourigenesis

2007 • 66 citations

Neural guidance molecules, tip cells, and mechanical factors in vascular development

2008 • 62 citations

Inhibition of cell-cell binding at the aggregation stage of Dictyostelium discoideum development by monoclonal antibodies directed against an 80,000-dalton surface glycoprotein.

1985 • 60 citations

Restoration of Functional Gap Junctions through Internal Ribosome Entry Site-Dependent Synthesis of Endogenous Connexins in Density-Inhibited Cancer Cells

2005 • 57 citations

Coordinating cell proliferation and migration in the lens and cornea

2007 • 52 citations

Micronodular transformation as a novel mechanism of VEGF-A-induced metastasis

2007 • 50 citations

Polysialylated NCAM Represses E-Cadherin-Mediated Cell-Cell Adhesion in Pancreatic Tumor Cells

2008 • 48 citations

Lack of Nidogen-1 and -2 Prevents Basement Membrane Assembly in Skin-Organotypic Coculture

2006 • 45 citations

Msx2 induces epithelial‐mesenchymal transition in mouse mammary epithelial cells through upregulation of Cripto‐1

2009 • 40 citations

Isolated Anxa5+/Sca-1+ perivascular cells from mouse meningeal vasculature retain their perivascular phenotype in vitro and in vivo

2007 • 39 citations

Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn’s disease and contributes to accelerated epithelial wound healingin vitro

2005 • 38 citations

Neuroglian stabilizes epithelial structure during Drosophila oogenesis

2004 • 32 citations

Dermal Lymphatic Emboli in Inflammatory and Noninflammatory Breast Cancer: A French-Tunisian Joint Study in 337 Patients

2005 • 31 citations

The current understanding of the molecular determinants of inflammatory breast cancer metastasis

2005 • 26 citations

Morphometric analysis of murine skin wound healing: Standardization of experimental procedures and impact of an advanced multitissue array technique

2007 • 25 citations

Diversity of desmosomal proteins in regenerating epidermis: immunohistochemical study using a human skin organ culture model

1999 • 25 citations

Procollagen I COOH-terminal fragment induces VEGF-A and CXCR4 expression in breast carcinoma cells

2008 • 24 citations

Migrating Cells Retain Gap Junction Plaque Structure and Function

2008 • 23 citations

In vivo fluorescence microscopy of corneal neovascularization

1998 • 16 citations