Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study

Fluorescence Energy Transfer as a Spectroscopic Ruler

1978 • 2,370 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

1982 • 877 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

The orientational freedom of molecular probes. The orientation factor in intramolecular energy transfer

1979 • 744 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Novel Interleukin-2 Receptor Subunit Detected by Cross-Linking Under High-Affinity Conditions

1986 • 585 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

IL-15: A Pleiotropic Cytokine with Diverse Receptor/Signaling Pathways Whose Expression Is Controlled at Multiple Levels

1996 • 459 citations

Surface density determination in membranes by fluorescence energy transfer

1978 • 422 citations

Cytoplasmic domains of the interleukin-2 receptor β and γ chains mediate the signal for T-cell proliferation

1994 • 340 citations

Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

1994 • 338 citations

THE MULTI-SUBUNIT INTERLEUKIN-2 RECEPTOR

1989 • 323 citations

Atomic structure of a human MHC molecule presenting an influenza virus peptide

1992 • 254 citations

Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY.

1996 • 253 citations

Flow cytometric measurement of fluorescence resonance energy transfer on cell surfaces. Quantitative evaluation of the transfer efficiency on a cell-by-cell basis

1984 • 203 citations

Establishment of an interleukin 2-dependent human T cell line from a patient with T cell chronic lymphocytic leukemia who is not infected with human T cell leukemia/lymphoma virus

1987 • 165 citations

Characterization of the interleukin 2 receptors (IL-2R) expressed on human natural killer cells activated in vivo by IL-2: association of the p64 IL-2R gamma chain with the IL-2R beta chain in functional intermediate-affinity IL-2R.

1992 • 135 citations

Fluorescence energy transfer measurements on cell surfaces: A critical comparison of steady‐state fluorimetric and flow cytometric methods

1984 • 132 citations

An associated molecule, p64, with IL-2 receptor beta chain. Its possible involvement in the formation of the functional intermediate-affinity IL-2 receptor complex.

1992 • 128 citations

Inhibitory influence of IL-4 on human B cell responsiveness.

1988 • 123 citations

Flow cytometric resonance energy transfer measurements support the association of a 95-kDa peptide termed T27 with the 55-kDa Tac peptide.

1987 • 99 citations

Structural hierarchy in the clustering of HLA class I molecules in the plasma membrane of human lymphoblastoid cells.

1995 • 87 citations

Physical association between MHC class I and class II molecules detected on the cell surface by flow cytometric energy transfer.

1989 • 79 citations

Identification of a direct interaction between interleukin 2 and the p64 interleukin 2 receptor gamma chain.

1993 • 76 citations

Lateral organization of the ICAM‐1 molecule at the surface of human lymphoblasts: A possible model for its co‐distribution with the IL‐2 receptor, class I and class II HLA molecules

1994 • 75 citations

New insights into membrane dynamics from the analysis of cell surface interactions by physical methods

1995 • 67 citations

Lateral diffusion of H-2 antigens on mouse fibroblasts.

1982 • 66 citations

Molecular basis for two different affinity states of the interleukin 2 receptor: affinity conversion model.

1986 • 62 citations

Immunoelectron Microscopy and Immunofluorescence in Membrane Biology

1978 • 61 citations

Dynamic receptor superstructures at the plasma membrane

1997 • 59 citations

The interleukin 2 receptor (IL-2R): the IL-2R alpha subunit alters the function of the IL-2R beta subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R alpha subunit.

1992 • 57 citations

Fluorescence Resonance Energy Transfer Reveals Interleukin (IL)-1-dependent Aggregation of IL-1 Type I Receptors That Correlates with Receptor Activation

1995 • 55 citations

Luminescence spectroscopic approaches in studying cell surface dynamics

1988 • 53 citations

Direct identification of the murine IL-2 receptor p55-p75 heterodimer in the absence of IL-2.

1988 • 40 citations

Role of α chain - IL-2 complex in the formation of the ternary complex of IL-2 and high-affinity IL-2 receptor

1990 • 38 citations

The IL-2 receptor alpha-chain alters the binding of IL-2 to the beta-chain.

1991 • 32 citations

Cooperative interactions between the interleukin 2 receptor alpha and beta chains alter the interleukin 2-binding affinity of the receptor subunits.

1994 • 30 citations

IL-4 inhibits the expression of high affinity IL-2 receptors on monoclonal human B cells.

1990 • 26 citations

Unexpected effects of the IL-2 receptor alpha subunit on high affinity IL-2 receptor assembly and function detected with a mutant IL-2 analog.

1993 • 23 citations

Major histocompatibility complex class I protein conformation altered by transmembrane potential changes

1997 • 23 citations

Evidence for p55–p75 heterodimers in the absence of IL-2 from Scatchard plot analysis

1992 • 23 citations

Synergistic action of monoclonal antibodies directed at p55 and p75 chains of the human IL-2-receptor.

1991 • 23 citations

Unexpected Effects of the IL-2 receptor alpha subunit on high affinity IL-2 receptor assembly and function detected with a mutant IL-2 analog

1993 • 23 citations

Biophysical Characterization of a Recombinant Soluble Interleukin 2 Receptor (Tac)

1996 • 21 citations

Transmembrane signalling in T cells

1992 • 20 citations

Stepwise formation of the high-affinity complex of the interleukin 2 receptor

1990 • 17 citations

Structure of the functional interleukin-2 receptor: Evidence for the association of human p55 and murine p75 molecules in a mouse T cell line

1989 • 10 citations

Detection and spatial distribution of IL-2 receptors on mouse T-lymphocytes by immunogold-labeled ligands.

1996 • 4 citations